1.Effects of Acer truncatum oil on oxidative stress and inflammatory reaction in rats undergoing one-time exhaustive exercise
Chongqing Medicine 2017;46(22):3043-3045
Objective To explore the effects of Acer truncatum oil on oxidative stress and inflammatory reaction in rats after exhaustive exercise to provide a scientific basis for the prevention of sports injury by Acer truncatum oil.Methods Thirty healthy male SD rats were randomly divided into control group (A,normal diet + saline every day),exhaustive group (B,normal diet + saline daily) and exhaustive with Acer truncatum oil group (C,0.21 mL/kg daily Acer truncatum oil gavage),6 weeks later,the rats performed once exhaustive swimming exercise,then the creatine kinase (CK),lactate dehydrogenase (LDH),cytokine interleukin (IL-1β,IL-10) and tumor necrosis factor alpha (TNF-α) in the serum;malondialdehyde (MDA) homogenate reduction glutathione (GSH),superoxide dismutase (SOD),catalase (CAT) and glutathione peroxidase (GSH-Px) in muscle were measured.Results After exhaustive exercise,when compared with the group A,the serum levels of CK,LDH,IL-1,TNF-α and IL-10 were significantly higher than in the group B(P<0.05,P<0.01,P<0.05,P<0.01,P<0.05),IL-10/ TNF-α ratio had no statistically significant difference(P>0.05),the level of MDA in gastrocnemius muscle increased significantly (P<0.05),GSH level and GSH-PX activity decreased significantly (P<0.05,P<0.01),SOD and CAT activity were not statistically significant (P>0.05).when compared with the group B,serum CK,LDH level and IL-1 β,TNF-α were significantly decreased (P<0.05,P<0.01,P<0.01,P<0.05),IL-10 had no statistical significance (P>0.05),a significant increase in IL-10/TNF-α(P<0.05),the level of MDA of gastrocnemius muscle decreased significantly (P<0.05),the level of GSH and SOD,CAT and GSH-PX were significantly increased (P<0,01,P<0.01,P<0.05,P<0.01).Conclusion Acer truncatum oil can significantly reduce oxidative stress and inflammatory reaction caused by the exhaustive exercise,which has a protective effect on skeletal muscle.
2.Clinical Study in Elderly Hypothyroidism with Coronary Heart Disease
Journal of Medical Research 2006;0(06):-
0.05,there were not significant differences in two groups.In the hypothyroidism group,the characteristics had been improved,such as myxedema、feeling of cold,lowing-sweat、alopeda,The function of thyroid and heart rate had been improved。To compare with matched control,there were significant difference P
3.The research about the relationship between emotional labor and personality of health care workers
Qing HU ; Jian SUN ; Hongwei SUN
Chinese Journal of Behavioral Medicine and Brain Science 2010;19(1):75-77
Objective To explore the relationship between the emotional labor and personality of the health care workers. Methods 168 health care workers in 6 hospitals of Shandong province were surveyed to complete the Emotional Labor Scale and the revised NEO personality inventory(NEO-PI-R). Results The first strategy of emotional labor that workers usually used was natural acting (5.17±1.15),the next one was deep act-ing (4.74±0.78) and the last was surface acting(3.88±1.21). The correlation analysis showed that the extro-version had a negative correlation (r=-0.20, P < 0.05) with the surface acting and a positive correlation (r=0. 31, P<0.01) with the deep acting. The agreeableness had a positive correlation (r=0.22, P < 0.05) with the nat-ural acting. The conscientiousness had a positive correlation (r=0.25, P<0.05) with the deep acting. The extro-version had significant negative influence on surface acting and significant positive influence on deep acting. The a-greeableness had positive significant effect on natural acting and the conscientiousness had positive significant effect on deep acting. Conclusion Personality influenced the emotional labor and gender,age,work tenure and ed-ucational had significant effect on emotional labor.
4.Median effective dose of esmolol for maintaining cardiovascular stability in elderly and non-elderly hypertensive patients during tracheal extubation
Huan GUO ; Ling YU ; Hongwei SUN
Chinese Journal of Postgraduates of Medicine 2016;39(6):561-564
Objective To study the optimal dose of esmolol for maintaining cardiovascular stability in patients with hypertension during tracheal extubation. Methods In post-anestheisa care unit, hypertensive patients after general anesthesia meeting the extubation criteria were included. Patients were divided into 2 groups according the age: group Ⅰ (>65 years old for the elderly hypertensive, 21 cases), and groupⅡ(≤65 years old for the non-elderly hypertensive, 22 cases). All the patients received esmolol bolus before sputum suction and tube extraction, and the tracheal extubation were extubated 2 minutes after esmolol bolus. The systolic blood pressure, diastolic blood pressure and heart rate were was recorded before tracheal extubation, 2 min after esmolol bolus, at the time of sputum suction extubation, 1 min after tracheal extubation, 3 min after tracheal extubation and 5 min after tracheal extubation. Esmolol dose was determined by the up and down method. Initial dose was 0.5 mg/kg, in accordance with the arithmetic dose (0.2 mg/kg) increasing or decreasing progressively. In negative results (the systolic blood pressure at extubation or 5 min after extubation ≥ 20% of the base, or the systolic blood pressure at sputum suction extubation>180 mmHg, 1 mmHg=0.133 kPa) esmolol dose increased progressively, and in positive results (the systolic blood pressure at extubation or 5 min after extubation<20%of the base) esmolol dose decreased progressively. When the crosspoint (from positive to negative result) reached 6, the study was terminated. Results The median effective doses of esmolol for maintaining cardiovascular stability in groupⅠand groupⅡwere (0.6 ± 0.1) and (0.8 ± 0.1) mg/kg. Conclusions Esmolol can maintain cardiovascular stability in patients with hypertension during tracheal extubation. Median effective dose decreases in older hypertensive patients.
5.Applied research on the evaluation of left ventricular function in the OSAS with 2D speckle tracking technique
Hongwei XU ; Haifeng SUN ; Tingting YIN
China Medical Equipment 2014;(10):17-19
Objective: To discuss the application value with two-dimensional ultrasound speckle tracking technique in the evaluation of left ventricular function in patients with OSAS. Methods: Selected 110 cases of hospital patients with OSAS in recent years, used STI technical analysis of left ventricular myocardium using different directions overall resilience, Left ventricular torsion and systolic mitral annular midpoint of the maximum displacement (MAD) and left ventricular ejection fraction (LVEF) relationship, performed using SPSS 17.0 statistical correlation analysis. Results: MAD had a significant correlation with LVEF(r=0.81, P<0.01); GLS(r=-0.74, P<0.01),GRS GRS(r=0.57, P<0.01),GCS (r=-0.55, P<0.01) and LVtw(r=0.65, P<0.01)were significantly associated with LVEF;MAD and GLs(r=-0.69, P<0.01),GRs (r=0.49, P<0.01), LVtw (r=0.45, P<0.01)were significantly associated;MAD and GCs (r=-0.39, P<0.05)with a negative correlation. Conclusion:STI resilience through the myocardium, ventricular torsion and systolic mitral annular maximum displacement at the midpoint of the analysis, can accurately evaluate left ventricular longitudinal, radial and torsional motion synchronization, highly correlated with left ventricular ejection fraction, good consistency, with a very broad application prospects.
6.Correlation of Physical and Mental Health with Coping and Defensive Style in Asthma Patients
Yanyu WANG ; Hongwei SUN ; Yuping SONG
Chinese Journal of Prevention and Control of Chronic Diseases 2006;0(01):-
Objective To explore the association of physical and mental health with coping and defensive style in asthma patients. Methods 190 adult patients with asthma were investigated with trait coping style questionnaire, defensive style questionnaire and short form 36 health survey questionnaire. Results The scores in group with higher score of health status were lower than those in group with lower score of health status in negative coping style, immature and middle defensive style, but higher in positive coping style (P
7.Experimental study on ischemic injury of certical spinal cord after acute artery block
Qizhi SUN ; Xianjun REN ; Hongwei HU
Orthopedic Journal of China 2006;0(20):-
[Objective]To study the effect on ischemic injury of cervical spinal cord(CSC) by comparison on two different blocks of arteries supplying CSC.[Method]Forty-eight rabbits were divided into two groups: Group A,ligation and section of anterior cervical spinal cord artery(ASCA);group B ligation and section of both ACSCA and bilateral vertebral arteries before its entramce the foraman(indirect block of Anterior cervical radicular artery(ACRA).Bdood flow changes of CSC were meansured after 6 h,24 h and 72 h(each N=6) and muscle motor cooked potential(MMEP),local energy metabolism,and cell morplotogical changes of CSC were observed.[Result]In group A,blood flow of CSC was going down markedly and showed 50.2% decrease,but got partial recovery at 24 h and 72 h.Delitescence of MMEP prolongcd,ATP and EC descended profressivtly,showing an ischemic changes,In group B there showed greate,changes about every observation thay that in group A with significant difference at every time poinl between two groups(P
8.Pathologicd characteristics of osteoarthritis secondary to acetabular dysplasia and the short-term effects of total hip replacement
Weiping SUN ; Jingxin HAO ; Hongwei DU
Orthopedic Journal of China 2006;0(17):-
[Objective]To summarize the experiences of total hip replacement with cementless joint components in the treatment of osteoarthritis secondary to acetabular dysplasia in adults and to evaluate its early effect. [Method]From March 2000 to March 2007, thirty hips in 25 adult patients with osteoarthritis secondary to acetabular dysplasia undergoing total hip replacement with cementless joint components were included in this study. Of the patients, 5 were male and 20 were female.Their ages ranged from 35 to 55 years with an average age of 55 years. The patients mainly complained of pain and claudication. According to the Hartofilakidis classification , Semi-dislocation occurred in 21 hips and high-dislocation in 9 hips.Five patients underwent bilateral total hip replacements and twenty patients had unilateral total hip replacement.[Result]The duration of follow-up ranged from 8 months to 7 years ( average 3 years and 9 months ) . The average Harris score was increased from 36.09 to 88.21 points, They could take care of themselves and returned to their previous job. All the patients were pain-free and there was no sign of aseptic looseing or subsidence.[Conclusion]Total hip replacement with cementless joint components is an effective method for the treatment of osteoarthritis secondray to acetabular dysplasia in adults.The key point to the success for operation are appropriate cementless joint components, deepened medial wall of the acetabulum and improved the techniques of bone graft in the true acetabulum.
9.Expression and significance of Skp2 and Cx43 in cervical carcinoma
Zhen LIANG ; Lixin SUN ; Hongwei ZHAO
Cancer Research and Clinic 2010;22(12):840-842
Objective To investigate the expression of Skp2 and Cx43 in cervical carcinoma and to study their relationships and clinical significance. Methods The expression of Skp2 and Cx43 was examined by immunohistochemical method in 48 cases of cervical carcinoma tissue, 84 cases of cervical intraepithelial neoplasia (CINⅠ - Ⅱ 45 cases, CINⅢ 39 cases), 28 cases of chronic cervicitis. Results Skp2 expression in cervical carcinoma was higher than that in the CINⅠ - Ⅱ and chronic cervicitis (P <0.05), Cx43 expression was lower in cervical carcinoma than that in the CINⅢ, CINⅠ - Ⅱ and chronic cervicitis (P <0.05). The expression of Skp2 was correlated with histological differentiation and lymph node metastasis (P <0.05). The expression of Cx43 was correlated with the lymph node metastasis (P <0.05). Besides, the expression of Skp2had a negative correlation with that of Cx43. Conclusion Skp2 and Cx43 may play an important role in the genesis and development of cervical carcinoma.
10.The mediating effects of coping styles on the relationship between coping resources and psychosomatic health in patients with asthma
Yanyu WANG ; Hongwei SUN ; Yuping SONG
Chinese Journal of Behavioral Medicine and Brain Science 2009;18(7):607-609
Objective To study the role of coping styles in the relationship between coping resources and psychosomatic health in patients with asthma. Methods 184 adult patients with asthma were investigated with General Serf-Efficacy Scale (GSES), Internality, Powerful Others, and Chance Scale (IPC), Social Support Rat-ing Scale (SSRS), Defensive Style Questionnaire (DSQ), Trait Coping Style Questionnaire (TCSQ) and Short Form 36 Health Survey Questionnaire (SF-36). Results Significant correlation between self-efficacy (r=0.356),locus of control(Ir=0.208, Pr=0.341, Cr=-0.349) ,subjective(r=0.201) and objective(r=0.189)social support, immature and middle ( r = - 0. 257 ) defensive styles and coping styles ( PCr = 0.231, NCr =-0.505 ) with Mental Component Summary (MCS) was found (all P <0.05), but Physical Component Summary (PCS) was only related to self-efficacy( r=0. 175) ,chance(r=0.150),immature(r=-0.256) and middle de-fensive Styles and negtive coping styles (all P < 0.05). PCS (t = - 5.189) and MCS (t = - 6. 758) could be predic-ted effectively by negative coping style (all P<0.01). Moreover, self-efficacy, powerful others and the use of so-cial support could had an effect on the health of patients through negative coping style. Conclusion Negative coping style could not only have a direct effect on the health of asthma patients but also be a mediator between self-efficacy, locus of control, social support and the health of patients.