Neuropathic pain (NPP) is a chronic pain that caused by a series of infection and nerve damage events .It has high incidence ,complex etiology and seriously affects patients′life quality .Although clinic trials gradually increased ,the treat-ment of neuropathic pain is still insufficient .Recent research focuses on reasonably using drugs of different mechanisms and time of duration .The progress of NPP drugs was reviewed in this paper for providing basis for treatment of neuropathic pain .