Benzene ; poisoning ; China ; Chronic Disease ; Humans ; Occupational Diseases ; diagnosis ; Occupational Exposure ; adverse effects

Benzene ; poisoning ; Chronic Disease ; Humans ; Poisoning ; diagnosis

Rotavirus (RV) is one of the major pathogens responsible for acute viral gastro-enteritis in children. The infec-tion of RV is dependent upon the recognition of the host cell speciifc receptors and attachment. Thus, receptors are the important factors of infection. Recent studies have suggested that a genetic factor might play a role in the susceptibility of hosts to RV infec-tion. Histo-blood group antigens have recently been discovered as receptors binding to RV, which are important for the study of evolution. Thus it will be also crucial for the pathogenesis and epidemiology and prevention and treatment for RV. In this article, we will review the correlation of the RV infection and histo-blood group antigens and further discuss the development of optimal vaccine.

Objective To explore the feasibility and importance of active monitoring of vancomycin‐related nephrotoxicity .Meth‐ods During July 2010 to July 2013 ,a total of 139 cases of inpatients received vancomycin through intravenous injection were en‐rolled in this study .The adverse drug reaction active monitoring and early warning system were utilized to evaluate patients with vancomycin positive events .Results Among the 139 cases of patients ,there was 9 cases of patients with renal damage .The inci‐dences of compensatory stage of renal insufficiency ,decompensatory stage of renal insufficiency ,renal failure stage and end‐stage re‐nal failure were 44 .44% ,22 .22% ,22 .22% and 11 .11% respectively .The positive warning rates when serum creatinine level was above 133 μmol/L ,increased by 50% compared with the baseline ,increased with 44 μmol/L based on the baseline were 55 .56% , 22 .22% and 22 .22% respectively ,and those positive warning rates in artificial relevance evaluation were 19 .18% ,19 .18% and 56 .54% respectively .Conclusion It is necessary to individualize utilization of vancomycin according to patients′s condition .

Nonalcoholic fatty liver disease(NAFLD)has become one of the most common liver diseases in the world.Considering the important role of insulin resistance in its pathogenic mechanisms,insulin sensitizers are becoming the promising pharmacological strategies for NAFLD.We collected and analyzed the relevant articles in recent years and found that pioglitazone,rosiglitazone and metformin could improve liver enzymes and insulin sensitivity of NAFLD.However,only pioglitazine was supported in ameliorating liver histology by envidences from randomized,double-blinded,controlled clinical trials.There were no much obvious adverse effects in NAFLD patients who received insulin senitizers.Small or medium samples and no more than 2 years of treatment course may be the major limitation of current studies.Future information derived from well-designed running trials will be useful in defining the clinical implications of insulin sensitizers in the treatment of NAFLD.

Objective To investigate the blocking effects of Pyrin domain protein on mouse allergic airway inflammation induced by ovalbumin and its mechanism.Methods Forty male BALB/c mice were randomly divided into 4 groups with 10 mice in each group.Control group:mice were treated with saline;OVA group:mice were sensitized and challenged with OVA; Pyrin domain protein 3 d group:mice were sensitized and challenged as asthmatic group and treated with 100 μg/kg triptolide before challenged; Pyrin domain protein 7 d group:mice were sensitized and challenged as asthmatic group and treated with 100 μg/kg triptolide before challenged.All mice were killed 24 h after final OVA challenge.The left lung was isolated for pathological examination.Lung sections were stained with hematoxylin and eosin(HE),Masson's trichrome.The thickness of bronchial airway,bronchial smooth muscle thickness,and the collagen deposition area were measured by image analysig system.The concentrations of IL-4,IL-5,TNF-α and IFN-γ in BALF were measured by ELISA,the RT-PCR and Western blot was performed to detect the mRNA expression of connective tissue growth factor (CTGF),TGF-β 1 mRNA and NF -kB from the right lung tissues.Results In OVA group,the number of inflammatory cells and the concentrations of IL-4,IL-5,TNF-a in BALF and Bronchial airway thickness,bronchial smooth muscle thickness,the collagen deposition area,CTGF,TGF-β1 mRNA and NF-kB in lung tissue were significantly higher than those in control group(P＜0.05).IFN-γ were lower than those in control group( P＜0.05 ).While in Pyrin domain protein 3 d group and Pyrin domain protein 7 d group,the number of inflammatory cells,the concentrations of IL-4,IL-5,TNF-α in BALF and bronchial airway thickness,bronchial smooth muscle thickness,the collagen deposition area and NF-kB in lung tissue were significantly lower than those in OVA group,IFN-γwere higher than those in OVA group( P ＜0.05).In Pyrin domain protein 7 d group CTGF and TGF-β1 mRNA in lung tissue were significantly lower than those in OVA group.Conclusion Pyrin domain protein might inhibits airway inflammation and development of airway remodeling in asthmatic mouse,the possible mechanism might in part by associated with reducing the expression of NF-kB and further inhibiting CTGF,TGF-β1.

Objective To study the part of Anti-thrombus and its property from Ground Beetle. Methods To dispart the Ground beetle into four segments which were shell, head, chest and abdomen, and adopt the method of frozen and melt to do the further test. Result Extracts of shell and chest were not active, extracts of head and abdomen were active. The activity of abdomen extracts was much better than that of the insect extracts. Its active component was glycoproteins. Conclusion The activity of abdomen extracts (Tf) is relatively high, and demonstrates wider value.

Objective　To study the possibility of measuring health status for residents in rural areas by the Chinese SF-36 scale. Methods　Health status for 207 residents in rural areas of Fuyang city who were 14 years old and over was measured by the Chinese SF-36 scale. The reliability and validity were analyzed. Results　The internal consistency reliability coefficients (Cronbach'α) exceeded 0.50 for all scales except SF and RE scales. Inter-scale correlation coefficients were lower than Cronbach'α coefficients for all scales except SF scale. Factor analysis identified three principal components, which could be used to explain 64.6% of the total variance. The differences of scale scores between the young group and the middle age group weren't significant. There weren't significant differences of scale scores between sexes except RP scale. The differences of scale scores between smokers and no-smokers, drinkers and no-drinkers weren't significant. Nor were the differences between various educational levels. Conclusion　Whether the Chinese SF-36 scale is suitable for measurement of health status for residents in rural areas needs further studies to give more evidences.

Objective To compare the effect of breathing oxygen or air on respiratory function training for chronic obstructive pulmonary disease (COPD). Methods 32 patients with stable COPD, pulmonary function Ⅱ～Ⅳ, were divided into 2 groups: oxygen (10males and 6 females and air (12 males and 4 females). All the patients participated in a standardized pulmonary rehabilitation program. They were assessed with St. George respiratory questionnaire, pulmonary function test, 6-minute walking distance, cardiopulmonary exercise test and Borg scale, maximal oxygen consumption (VO2max) before and after training. Results After 8 weeks of pulmonary rehabilitation, the VO2max in oxygen group increased compared with that of the air. Conclusion Supplying oxygen during training can increase the tolerance of COPD patients.

: Objective To investigate the effects of exercise therapy on activity of daily living (ADL), perception of dyspnea and quality of life (QOL) in stable patients with chronic obstructive pulmonary disease (COPD). Methods 40 COPD stable patients accepted treadmill exercise for 8 weeks. 6-min walk test (6MWT), the parameters of cardiopulmonary exercise test, ADL, perception of dyspnea (Borg Scale), and St. George's respiratory questionnaire (SGRQ) were measured before and after exercise. Results ADLs in different levels (P<0.05), especially in higher level (P<0.01), were significantly improved in all patients after exercise. Perception of dyspnea (Borg Scale) was also improved significantly (P<0.01). There was positive correlation between ADL and QOL （r=0.455, P<0.01), but negative between dyspnea and QOL （r=-0.412,P<0.05). Conclusion Exercise therapy can improve the ADL and perception of dyspnea in daily activities in patients with COPD, as well as QOL.