Objective To observe the effect of combination therapy with methotrexate,sulfasalazine and hydroxychloroquine on serum lipids in elderly patients with rheumatoid arthritis (RA).Methods 136 patients with RA were randomly divided into group A and group B (n=68,each).Patients in group A were treated with methotrexate,sulfasalazine and hydroxychloroquine sulfate plus life style intervention.Patients in group B were treated with the therapy as same as that of group A and received xuezhikang additionally.The levels of cholesterol (TC),low density lipoprotein cholesterol (LDL-C),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),C-reactive protein (CRP),erythrocyte sedimentation rate (ESR) were determined before and 6 months after treatment.Disease activity was assessed by DAS28,swelling index,joint pain index,duration of morning stiffness.Results The levels of TC,TG and LDL-C were lower and HDL-C level was higher in the two groups after 6 months of the treatment than before treatment (all P＜ 0.05).DAS28,ESR,CRP,joint tenderness,joint swelling and duration of morning stiffness were significantly reduced in two groups after 6 months of the treatment as compared with pretreatment (all P＜0.05).There was no significant difference in levels of TC,TG,LDL-C,HDL-C,DAS28,ESR,CRP,joint tenderness,joint swelling and duration of morning stiffness between the two groups after treatment.There were no obvious differences in liver and kidney function between the two groups before and after treatment.Conclusions Blood lipids levels are abnormal in RA patients.The slow acting antirheumatic drugs have certain effect on blood lipids when alleviating disease symptoms.

0.05).There was significant difference at 6 h,24 h and 1 week(P

Nonalcoholic fatty liver disease(NAFLD)has become one of the most common liver diseases in the world.Considering the important role of insulin resistance in its pathogenic mechanisms,insulin sensitizers are becoming the promising pharmacological strategies for NAFLD.We collected and analyzed the relevant articles in recent years and found that pioglitazone,rosiglitazone and metformin could improve liver enzymes and insulin sensitivity of NAFLD.However,only pioglitazine was supported in ameliorating liver histology by envidences from randomized,double-blinded,controlled clinical trials.There were no much obvious adverse effects in NAFLD patients who received insulin senitizers.Small or medium samples and no more than 2 years of treatment course may be the major limitation of current studies.Future information derived from well-designed running trials will be useful in defining the clinical implications of insulin sensitizers in the treatment of NAFLD.

Objective To assess the efficacy of clinical intervention of early swallowing syndrome on neonates. Methods Eighty-six cases of normal newborns were enrolled in the study, including 44 cases of natural delivery,32 cases of cesarean section,8 cases of premature infant. The cases started vomitting before feeding the milk, became more severe after feeding the milk. once the pathological factors were excluded, the cases were treated with breastfeeding, warm water enema, massaging the lower abdomen, 1% sodium bicarbonate solution to the gastric lavage. Results A variety of clinical interventions on the control of neonatal swallowing syndrome results are obvious. Conclusions Early detection early intervention can prevent complications occurring.

0.05).[Conclusion]Periarticular drug injection during TKA and intra-articular drug injection after operation can relieve pain early after TKA,improve the range of motion of the knee and rehabilitation,no further side effect has been noted.

Objective To establish a new inhibitory kinetic spectrophotometric method for the determination of trace Sb3+ in water sample. Methods A new inhibitory kinetic spectrophotometric method for the determination of trace Sb3+ was established based on the inhibitory effect of Sb3+ on the oxidation of thionine by H2O2 in a buffer solution of NH3-NH4Cl at pH=10.50. Results The linear range of this method was 0.004-0.40 ?g/ml, r=0.999 2,the limit of detection was 1.71?10-3 ?g/ml, and RSDs were 1.4%～ 2.1% , the recovery rates were 96.2% -101.9% . Conclusion This method is accurate, fast, simple and applicable to the determination of antimony content in environment water samples.

Objective To investigate the relationships between exercise and exercise self-efficacy and knowledge in pregnant women. Methods A total of 274 pregnant women were recruited from a tertiary level first class hospital from July to November 2015 in Guangzhou by convenience sampling method. They were investigated with the social relational scale, the Pregnancy Physical Activity Questionaire, the Pregnancy Exercise Self-efficacy Scale, the Pregnancy Exercise knowledge Scale. Results Only 22.6％ (62/274) of the women met the international guideline for exercise. Score of the exercise self-efficacy and exercise were positively correlated(r=0.203, P=0.000). Score of the knowledge and exercise were positively correlated(r=0.103, P=0.032). Score of the exercise self-efficacy and knowledge were meaningless(r=0.098, P=0.106). Conclusions It is suggested to take more actions to enhance the recognition of pregnant women for exercise. Conviction formed after thinking knowledge gradually, by faith again dominate action, ultimately promote the perinatal health of pregnant women.

Objective To test the reliability and validity of the Chinese version of the Pregnancy Exercise Self-Efficacy Scale(P-ESES) among Chinese population. Methods The Chinese version of P-ESES was translated from the original one,back-translated and adjusted for cultural adaptation. The reliability and validity were tested among 274 eligible pregnant women recruited in one obstetric outpatient clinic from a tertiary hospital in Guangzhou using convenience sampling. Results The content validity index (CVI) of the Chinese version of P-ESES was 0.98. Factor analysis extracted three common factors,which explained 60.649% of the total variance,and each item had high fac-tor loading quantity(>0.4). The test-retest reliability was 0.531,and Cronbach's α coefficient was 0.804. Conclusion The Chinese version of the P-ESES has been proved to be reliable and valid. It is a valuable tool for evaluating exercise self-efficacy among pregnant women in mainland China.

Since the current worldwide medical education and clinical practice lay a particular stress on training medical students with scientific knowledge and medical technical skills,enormous medical staffs are shaped into medical technical workers who lack medical morality and emotions,leading to the contradiction between medical morality and technologies.Medical personnel should know that medicine not only observes illness closely,but also attaches importance to the patients themselves who are suffering the pain.Medical students should pay attention to the forming process of medical morality and emotion in their preparative stage,accept the exercise to prepare for medical morality,and recalls their love and concern for life.