The classifications of the thymoma and their pathologic diagnosis is closely related to the clinical treatment of the disease. Similarly, it is a focal on the clinicopathologic study today. In this paper,the classification of the thymoma and their developing process in the histopathological changes was extensively discussed, and various type of the histopatholgic characteristic of the tumor was compared. It was suggested the new edition of the thymoma classifications of WHO should be operated in practical work. Additionally, the B1 type thymom, the thymic lymphoma and the histopathological changes of thymus in myasthenia gravis patients were described respectively, and it was also considered that the new edition of the thymoma classifications of WHO had some incomplete aspects in the pathological diagnosis.

Objective: To observe the effect of acupoint catgut embedding therapy in treating postpartum obesity. Methods: According to the clinical standard, observing the effect of reducing weight through 120 postpartum obesity patients by the therapy of acupoint catgut embedding. Results: The follow-up observation showed that the result was satisfied. The total effective rate was 91.67%. Conclusion: The acupoint catgut embedding therapy played a positive role in reducing weight of the postpartum obesity patients. This therapy can achieve reducing weight well by enhancing the physical body, regulating endocrine, restraining appetite, and accelerating fat metabolism.

Objective MicroRNAs (miRNAs) are of important clinical value in various tumors.However, few studies are reported about their role in thymic epithelial tumors.This article aims to explore differential expression profile of miRNAs in type B3 thymoma and thymic carcinoma.Methods This study included the pathological data about 45 cases of type B3 thymoma and thymic carcinoma surgically treated in our hospital from January 2012 to January 2015, of which 3 cases of type B3 thymoma (control group) and another 3 cases of thymic carcinoma (case group) were subjected to miRNA microarray for determination of the differential expressions of miRNAs in the tumor tissues.The up-and down-regulated miRNAs were calculated, their target genes were predicted via online databases, and the thymus-related genes were identified.Results Totally, 32 differentially expressed miRNAs (including miR-125b-1-3p, miR-3175, and miR-4462) were up-regulated and another 19 (including miR-361-5p, miR-130a-3p, and miR-3651) down-regulated in thymic carcinoma.AKT1, C9, CD19, CDC42, LSS, and MYC were identified as the target genes of miR-377-5p, ADCYAP1R1, ASPA, CAD, and CD63 as the target genes of miR-458-5p, and AKAP12, CD28, FOXP1, and MDM4 as the target genes of miR-183-5p.Conclusion Differentially expressed miRNAs were identified in type B3 thymoma and thymic carcinoma and their target genes predicted using the prediction software, which may provide some valid evidence for further study of thymic epithelial tumors.

Objectives:To study the clinicopathological changes of mediastinum lesions.　Methods:Specimens from 405 cases of mediastinum lesions from 1967 to 1997 were studied.　Results:Sex ratio, male to female was 216 to 189, median age was 26 years. There were 230(56.8%) cases of tumors and tumor-like lesions, 172(42.5%) cases manifested with myasthenia gravis. Case composition, 113 cases of thymus lesion(49.1%), 36 cases(15.7%) of germ cell tumors, 30 cases(13.0%) of neurological neoplasm, 6 cases(2.6%) of lymphoma, and 29 cases(12.6%) of cysts. Location, 165 cases(71.7%) were in the front mediastinum in which thymoma was the commonest, 6 cases(2.6%) were in the middle mediastinum in which lymphoma was the commonest, 30 cases were from the posterior mediastinum in which neurological tumors were the commonest. Follicular proliferation of the thymus was observed in 145 cases(84.3%) of MG, and 27 cases did not(15.7%) . Thirty eight cases(22.1%) of MG were from thymoma, and 12 cases(7.0%) from microscopic thymoma.　Conclusions: Prognosis of MG with thymus follicular proliferation was better than those without proliferation and thymoma, fortunately, most thymus with MG were follicular proliferative. Microscopic thymoma could be discovered on pathology. Thymus tumors consisted more than half of the mediastinum neoplasm, the incident of lymphoma was low.

BACKGROUND:Due to complicated and special lumbar spinal stenosis disease and different degrees of lumbar degeneration in the elderly, it requires very careful choice of repair methods and repair technology.
OBJECTIVE:To investigate the indications and prognosis effect of the treatments of elderly lumbar spinal stenosis by selective decompression of lumbar root canal under direct vision and laminectomy.
METHODS:Clinical data of 167 elderly patients with lumbar spinal stenosis were retrospectively analyzed. A total of 82 patients were treated with selective decompression of lumbar root canal as the selective decompression group, with a clear nerve root compression but without central canal stenosis. A total of 85 patients were treated with laminectom and treated with pedicle screw fixation as the whole lamina cut group, with distinct central canal stenosis. The indications were analyzed between the two groups. Clinical effects were assessed using Japanese Orthopaedic Association and Oswestry Disability Index before and after surgery.
RESULTS AND CONCLUSION:(1) Al patients were operated successful y. There was no serious
complication during treatment. (2) Japanese Orthopaedic Association and Oswestry Disability Index were significantly improved at last fol ow-up in two groups compared with preoperation (P<0.05). No significant difference in Japanese Orthopaedic Association and Oswestry Disability Index was detected between the two groups at various time points (P>0.05). Clinical symptoms disappeared or relieved at last fol ow-up in two groups. The prognosis in two groups had significantly improved. (3) Results indicated that laminectomy and pedicle screw fixation in elderly patients with lumbar spinal stenosis and central canal stenosis obtained significant effects. For elderly patients with lumbar spinal stenosis but without central canal stenosis, selective decompression of lumbar root canal under direct vision was given, and it is effective and reliable. The two methods are suitable for different patients, and are effective and reliable way to repair.

Objective To investigate the microenvironment of the thymus on lymphocytes, dendritic cells and epithelial cells were studied in patients with myasthenia gravis.Methods (1) The thymus specimens of 25 cases were examined using light microscopy,in which 10 were males,15 females with an average age of 31 years old. The lymphoid tissue with proliferation was in 13 cases, without proliferation in 12 cases. Additionally, 7 cases had congenital heart disease (the average age was 27 years old) and the thymus of an infant (1 case) was examined. (2) Immunohistochemical staining for CD1a?CD4?CD8?CD20?CD45RO?S 100?CKPan and EMA were performed onto the specimens. Some of them with positive dendritic cells on S 100 and CD1a were counted. Results (1) It showed that the positive cells of CD1a located at cortical areas of the thymus with or without lymphoid tissue proliferation in MG and non MG cases. However, there were some positive cells in the medulla, Hassall corpuscles and the vascular space areas of the thymus. (2) The CD4 staining was negative. (3) The expression of CD8 and CD45RO was expressed in the medulla, peripheral areas of the Hassall corpuscles and vascular space of the thymus. (4) CD20 was expressed in the medulla and the germinal central areas. (5) The expression of S 100 for dendritic cells were 23.5 and 47.5 per 100 mm 2 in both having medullary follicular hyperplasia and no follicular hyperplasia groups. The CD1a were 2.1, 3.8 per 100 mm 2, respectively. The statistic was significant as compared with both groups with or without proliferation of thymus medulla. (6) The expression of CK was located in the cortex, medulla and Hassall corpuscles. But EMA, CEA were negative. Conclusions (1) There were expressions of suppressive T cells (CD8) and B lymphocytes (CD20) with or without the thymus medullary lymphoid follicular hyperplasia. (2) The changes of numerous quantity of the dendritic cells on the thymus were displayed which showed a relation to the proliferation of T, B lymphocytes and the formation of germinal central of thymus.It suggested that the dendritic cells and the other stromal cells of the thymus may serve as an important role in MG occurrence.

Objective To investigate the role of matrix metalloproteinase 2, 9 (MMP 2, MMP 9) and tissue inhibitor of matrix metalloproteinases 2, 1(TIMP 2, TIMP 1 ) in human amniochorionic membrane Methods Amniochorionic membranes were collected from the following groups of women: (1) women with spontaneous premature rupture of membrane (PROM) before onset of labor (PROM group, n =8), (2) Women with term labor after vaginal delivery (vaginal delivery group, n =8), (3) Women undergoing elective cesarean section (C section group, n =8) Messenger ribonucleic acid expression for MMP 2, MMP 9, and their specific inhibitors TIMP 2 and TIMP 1 were studied with reverse transcriptase polymerase chain reaction Results (1)MMP 2 level in PROM group was 0 849?0 037;in vaginal delivery group 0 327?0 023;in C section group 0 307?0 028 Expression in PROM group was highest, with significant difference compared with the other groups ( P 0 05) (2)MMP 9 level in PROM group was 0 026?0 004;in vaginal delivery group 0 008?0 001,with significant difference between the two groups ( P 0 05) Conclusions In PROM group,the expression of MMP 2, MMP 9 and their inhibitors TIMP 2, TIMP 1 is imbalanced, leading to increased extracellular matrix degradation, and weakening of the fetal membranes, and eventually premature rupture of the membranes

In order to better play an important role of pathology consultations in the routine work of clinical pathology,and to solve the problems presented during consultation,we comprehensively analyze the reasons that cause pathology consulation,the pathological data management,patient-physician dispute,medical liability,as well as other aspects involved in consulation.Meanwhile,measures to resolve these problems are also proposed.

Objective To assess the diagnostic value of coronary CTA (CCTA) combined myocardial CT perfusion imaging (CTP) in coronary artery disease (CAD) with Meta-analysis.Methods Chinese and English literatures evaluating CCTA combined CTP in diagnosis of CAD in PubMed,Wed of Science,Cochrane Library,China National Knowledge Infrastructure (CNKI) and Wanfang Periodical Database from inception to December 2016 were searched.The extraction was conducted according to the criteria for diagnostic recommended by Cochrane Method Group.The quality of included studies was assessed with quality assessment of diagnostic accuracy studies-2 instrument.The statistical analysis was performed by Meta-disc 1.4 software,the diagnosis efficacy was calculated and the symmetric receiver operating characteristic curves (SROC) was drawn to obtain the area under curve (AUC).Results Five studies involving a total of 611 vessels were included.The pooled sensitivity (SEN),specificity (SPE),diagnostic odds ratio (DOR),positive likelihood ratio (PLR),negative likelihood ratio (NLR) were 0.96 (95％CI [0.92,0.98]),0.91 (95％CI [0.88,0.94],206.14 (95％CI [100,424.94]),9.33 (95％CI [5.57,15.61]),0.06 (95％CI [0.03,0.13]),respectively.The AUC of SROC was 0.977.Conclusion CCTA combined CTP has significant value in diagnosis of CAD.

Purpose To investigate the clinicopathologic changes of the lung epithelial tumor with epithelioid granuloma. Methods E-leven cases of lung malignant tumor with epithelial epithelioid granuloma reaction were studied according to the histological changes of lung epithelial tumor, immunophenotype, acid-fast staining, and tuberculosis PCR test results combined with follow-up data. Results The mean age was 62. 3 years, and male to female ratio was 10∶ 1. The main clinical manifestations displayed a cough, chest pain, fever and hemoptysis or bloody sputum. Nine cases were malignant tumors, tuberculosis or inflammatory lesions was 1 case each in pre-vious surgery. The tumor with epithelioid granuloma formation of the 11 cases displayed in the same site ( mixed) . The histopathologic changes of the lesions showed a epithelioid or typical tuberculous granulomas formation, including 4 cases of adenocarcinoma, 5 cases of squamous cell carcinoma and 2 cases of neuroendocrine tumors. The acid-fast bacilli staining was positive in 3 cases;6 cases were positive for PCR detection of mycobacterium tuberculosis. 5 patients died within 2 years due to various causes. Conclusions The lung epithelial tumors with epithelioid granuloma is more commonly found in the middle-aged, The signs and symptoms of the patients are similar to primary epithelial malignant tumors of the lung . The biological behavior was progressive with poor prognosis. The diagnosis of the lesions depends on pathological examination. It is very important to pay more attention to the pathological examination, especially in lung puncture samples, and the differential diagnosis for a definate diagnosis and treatment.