Objective To explore the efficacy and safety of the fiberoptic bronchoscope high frequency endotherm knife combined with balloon dilatation in treating tuberculosis inflammatory airway constriction.Methods According to the different treatment methods,63 patients with tuberculosis airway constriction were divided into two groups:the balloon dilatation group (balloon group,34 cases) and high frequency endotherm knife combined with balloon dilatation group (combination group,29 cases).The patients in both groups accepted endoscopic therapy once a week.Effective rate of recanalization for the narrow airway,treatment frequency,the time spent in tuberculosis bacterium clearing,as well as intraoperative and postoperative complications were recorded.Results The rate of recanalization in baboon group and combination group were 52.9％ (18/34) and 79.3％ (23/29),and there was significant difference (x2 =4.79,P =0.03).The treatment frequency in balloon group and combination group were (3.5 ± 1.3) times and (1.5 ± 1.1) times,and there was significant difference (t =6.53,P ＜ 0.01).The time spent in tuberculosis bacterium clearing in balloon group and combination group were (22.3 ± 3.6) d and (12.3 ± 2.1) d,and there was significant difference (t =11.69,P ＜ 0.01).Conclusions Fiberoptic bronchoscope high frequency endotherm knife combined with balloon dilatation in treating tuberculosis inflammatory airway constriction is efficient and safe.It can reduce the frequency of interventional therapy,shorten the time spent in tuberculosis bacterium clearing,which is worthy of clinical application.

The article is discussed about the literal meaning of the constitution, definition of the constitution from the ancients and today, recognition about the body by TCM, the value of constitutional medicine, relation with quality, syndrome, anatomy, psychology and so on. Constitution is the basic composition and structure in body from the standpoint of the author.

Objective To investigate the effect of Orthodontic traction and porcelain in the treatment of anterior teeth subgingival quit.Methods 63 patients with anterior teeth subgingival quit were randomly assigned into observation group and control group,the control group were treated with conventional processing methods,the observation group were treated with orthodontic traction and porcelain repair nethod.the efficient and general treatment were compared.Results In the observation group,there were 12 cases cured,17 cases effective,2 cases ineffective,the total effective rate was 93.55％ (29/31) ; in the control group,there were 9 cases cured,14 cases effective,9 cases ineffctive,the total effective rate was 71.88％ (23/32).There were significantly difference between two groups (x2 =5.1323,P =0.0235).Tooth loose degrees,gingival condition and periodontal status and treatment of bone resorption rates of the observation group were 93.55％,93.55％,100.00％ and 96.77％,significantly higher than the control(71.88％,68.75％,71.88％,75.00％),the differences were statistically significant (all P ＜ 0.05).Crown retention between the two groups showed no significant difference between cases (P ＞ 0.05).Conclusion orthodontictraction has good effect in the treatment of former porcelain subgingival root pruning.

Objectives:To investigate the effects of early enteral feeding(EEF) after hemorrhagic shock(HS) on gut structure and function,hormones for stress and metabolism and nutritional conditions. Methods:Seventy two Wistar rats were randomly divided into sham shock group(SS),HS group(HS) and post HS EEF gorup(HSE).HSE group was fed with ENSURE and HS group was fed with normal saline.EEF was started within 1 hour after resuscitation.The body weight,liver weight,musculus gastrocnemius weight,nitrogen content in liver and musculus gastrocnemius,total plasma protein level,albumin level,MDA(malondialdehyde) and Na + K + ATPase activity in stomach and jejunum mucosa, the change of liver function, the levels of glucagon,cortisol and insulin,and the pathological changes in stomach, small intestine and liver were investigated at 2,6,24,48 h after resuscitation. Results:When compared with HS group,the weight of body,liver and musculus gastrocnemius,the nitrogen content in liver and musculus gastrocnemius,the levels of total plasma protein and albumin and the liver function were significantly better in the HSE group.MDA content was less and Na + K + ATPase activity was higher in HSE group than those in HS group.The glucagon and cortisol levels were significantly lower and the insulin level was significantly higher in HSE group than those in HS group.The pathological changes in the stomach,intestine and liver in HSE group got an obvious improvement. Conclusions:After HS,EEF is helpful to maintain visceral organ function,reduce the stress and hypermetabolic response and improve the nutritional conditions.

OBJECTIVE: To analyze the characteristics of adverse drug reaction (ADR) induced by Levofloxacin (LVFX) injection and to promote rational use of drugs in the clinic. METHODS: 137 LVFX injection-induced ADR cases reported in our hospital during 2006～2009 were collected and analyzed statistically with Excel in respect of age, gender, medication and clinical manifestation, etc. RESULTS: ADR cases occurred nearly in all ages of people, and 32.85% were appeared in people over 60 years. Main clinical manifestations were lesion of skin and its appedants (62.04%) and gastrointestinal injury (16.06%). Most of them were mild and medium ADR. CONCLUSION: Great importance should be attached to the rational use of LVFX injection and ADR monitoring to guarantee the safety of patients.

Objectives To investigate the association between HLA-DQB1 alleles and Han Chinese with generalized pustular psoriasis (GPP) from Shandong. Methods The distributing frequencies of HLA-DQB1 alleles were detected with polymerase chain reaction-sequence specific primers (PCR-SSP) in 38 GPP patients and 94 healthy subjects from Shandong. Results ①The frequencies of HLA-DQB1*0201 and *0603 alleles increased significantly in GPP patients compared with those of the healthy controls(Pc = 0.005 and Pc = 0.013 , respectively), and the frequency of HLA- DQB1*0604 alleles decreased (OR = 0.08, Pc = 0.039). ②There were significant association between the GPP patients with a previous history of psoriasis vulgaris and HLA-DQB1*0201 and *0603 alleles (OR = 32.31, Pc = 0.005; OR = 12.42, Pc = 0.005, respectively), and between the GPP patients without the history and HLA-DQB1*0602 alleles (OR = 5.60, Pc = 0.039). Conclusions HLA-DQB1*0201 and *0603 alleles are significantly associated with the Chinese patients with GPP in Han population from Shandong. There is a significant heterogeneity in the GPP patients with and without the history of psoriasis vulgaris.

Objective:To isolate and purify glucocorticoid receptor(GR) of rat liver with HPHIC and verify the existence of the low affinity GR as the further evidence for theoretical basis of large dose glucocorticoid treatment.Methods:The supernatant of the rat liver was performed with Pseudoscatchard assay and HPHIC analysis after ultracentrifuge.SDS PAGE and Western blot were used to identify GR.Results:At the standard atmosphere,when the temperature was at 0 4℃,only one peak appeared at 9 11 min.When the temperature was at 25℃ and the concentration of 3H Dex exceeded 50 nmol/L,two peaks appeared at 3 7 min and 9 11 min.The protein was verified with SDS PAGE and Western blot, its molecular weight was 60 000,which could be bound with monoclonal antibody of GR.Conclusion:Two peaks of GR appears with HPHIC analysis, suggesting they may be high and low affinity receptor.Further researches are necessary to ascertain it. [

Objective To observe the DNA damage in the human lung fibroblasts(HLF)induced by insoluble nickel compounds(Ni3S2 and Ni2O3)and soluble nickel compound(NiSO4),and to study the mechanism of carcinogenesis.Methods The DNA damage of HLF cells treated with different concentrations of Ni3S2,Ni2O3 and NiSO4 were detected with the method of single cell gel electrophoresis(SCGE).Results All of the three kinds of nickel compounds significantly caused DNA damage in HLF cells,the average tail moments of all nickel-treated groups were larger than those in the control group(P

This paper analyzes the disqualification factors influencing B-D test results by using B-D test monitoring. Effective methods were taken to remove them and the problems were found in time for overhauling the sterilizer. The forevacuum steam sterilizer should be kept in good state and regulated strictly so that it can work in program with qualified sterilizing quality,thus ensuing a safe and reliable clinical application.

Subject To explore the features of the abnormalities of the sex chromatin and the sex chromosome of the patients with mental disorders. Methods The sex chromatin in the cells of buccal mucous membrane of the 2 784 patients with mental disorders were examined by using a blinding and random way. The chromosome karyotypes in peripheral blood were further examined in those whose measure showed abnormal. The comparison group consisted of 1 069 normal persons.Results Compaired with the control group,the average frequency of Y chromatin in the male patients [(28.0±6.6)%] and the average frequency of X chromatin in the female patients [(22.3±8.0)%] rose significantly ; the average frequency of X chromatin in the female patients of the schizophrenia subgroup and the affective disorder subgroup were higher than that of neurosis and psychogenic mental disorder subgroup. X chromatins of eight male patients were positive and the karyotypes of the abnormal X chromosome were 47,XXY in 3 cases and 47,XXY/46,XY in 5 cases, the rate of 47,XXY was 7.7 , it rose significantly to the control group. X chromatin of two female patients were negative and the karyotypes of the abnormal X chromosome was 45,X/46,XX, the rate of 45,X was 1.2 ; one female patient had double X chromatin and the karyotypes of the abnormal X chromosome was 47,XXX/46,XX,there is no abnormal sex chromatin and sex chromosome in the control group.Conclusions The higher rate of the sex chromatin might be closely associated with the tendency of heredity of mental disorders , and the rate of the lacking X chromosome in females and the increasing X chromosome in males rise in the patients with mental disorders.