1.Analysis of Deanxit-combined Treatment of Functional Dyspepsia
Journal of Kunming Medical University 2016;37(8):72-74
Objective To investigate the improvement and safety of the conventional treatment combined with Deanxit in the treatment of digestive adverse (FD) of gastrointestinal symptoms and sleep efficacy.Methods Ninety cases of patients with FD were randomly divided into the control group (pantoprazole capsule and Mosapride will + Capsule associated with sleep disorders with estazolam tablets) and observation group (pantoprazole capsule and Mosapride will + capsule with sleep disorders and estazolam tablets plus Deanxit).Both groups were treated for 4 weeks.After the course of treatment,the improvement degree and adverse reaction of digestive tract symptoms and sleep were compared between the two groups.Results After 4 weeks of treatment in the observation group with gastrointestinal symptoms were improved and the total effective rate was 86.7%,higher than that of the control group (66.7%).The difference was statistically gigmificart (P < 0.05).The total effective rate of was sleep disorders improvement 83.3%,higher than that of control group (61.9%),but the difference was not statistically significant (P > 0.05).Adverse reaction rates were not significantly different between the two groups.Conclusion On the basis of conventional therapy,treatment of functional dyspepsia (FD) with Deanxit can significantly alleviate gastrointestinal symptoms.Medication after 3-7 days can relieve the symptoms.After 4 weeks,the total efficiency is the highest with fewer adverse reactions.Clinical application is recommended.
2.Mental Health and Family Function of Elderly regularly participating Community Activity
Chinese Mental Health Journal 1989;0(03):-
Objective: To study mental health and family function of elderly regularly participating community activity Method: 107 elderly living in urban area and regularly participating community activities were assessed with SCL-90 and FAD (family assessment device) 43 elderly in same area but seldom participating such activity were collected as control and assessed with same instruments Results:The two groups had no significant difference in SCL-90 In study group, many subscores of FAD, such as problem solving, family role, and communication in family, had significant correlation with result of SCL-90 Conclusion: Elderly who regularly participate community activities are similar in mental health with those do not Family function has relation to mental health
3.The gene frequencies of HLA-Cw in Guangdong Han population and its significance
Lulu XIAO ; Hongjing MA ; Xiaolin YIN ; Xin YE ; Weidong ZHANG ; Kunyuan GUO
Chinese Journal of Immunology 1986;0(04):-
Objective:To explore the gene frequencies of HLA-Cw and to analyze the recognition characteristic between HLA-Cw and KIR in Guangdong Han population.Methods:An auto semi-quantitative PCR-RSSO method was adopted to detect the HLA-Cw genotypes of a sample of 122 bone marrow donors.Results:The gene frequencies of HLA-CW 03,07,01,08,04,14,15,12,06,05,16 were 0.237 1 , 0.215 9 , 0.175 2 , 0.112 9 , 0.050 5 , 0.041 9 , 0.041 9 , 0.037 6 , 0.033 3 , 0.008 2 , 0.004 1 respectively.HLA-Cw 02,04,05,06 belong to “group 1” recognizing KIR-2DL1/2DS1.HLA-Cw 01,03,07,08 belong to “group 2” recognizing KIR-2DL2/2DL3;2DS2/2DS3.There was a significant difference between the two groups in total HLA-Cw gene frequencies in Guangdong Han population( P
4.Retrospective comparative study of preoperative complications and lymphadenectomy between thoracoscopic esophagectomy and open procedure
Mingquan MA ; Hongjing JIANG ; Peng TANG ; Xiaofeng DUAN ; Lei GONG ; Zhentao YU
Chinese Journal of Thoracic and Cardiovascular Surgery 2015;31(5):260-263
Objective To analyze the differences in paraoperative morbidity and lymph node dissection between thoracoscopic esophagectomy and open procedure.Methods From October 2012 to April 2014,207 patients with esophageal cancer underwent surgery.125 patients underwent video-assisted esophagectomy,and 82 underwent open procedure.In the minimally invasive group,there were 109 thoracoscopic cases and 16 thoracolaparoscopic cases.Results There were significant differences between the thoracoscope group and the open group in atelectasis(0.8% vs.7.3%,P < 0.05),pleural effusion (0 vs.4.9%,P < 0.05),acute respiratory distress (0 vs.6.1%,P < 0.05),ligation of thoracic duct (3.2% vs.15.9 %,P < 0.05),recurrent laryngeal nerve paralysis (19.2% vs.32.9%,P < 0.05),c hylothorax (0 vs.4.9%,P < 0.05),number of lymphonode along the right recurrent laryngeal nerve lymphatic chains[1.91 ± 0.73 vs.1.12 ± 0.81,P < 0.05)] and achievement ratio(97.6% vs.89.0%,P <0.05) and number of lymphonode along the left recurrent laryngeal nerve lymphatic chains (0.93 ± 0.71 vs.1.76 ± 0.84,P < 0.05) and achievement ratio(52% vs.76.8%,P < 0.05).No significant differences were observed in pneumonia,anastomotic leak,thoracic abscess,esophago-tracheal fistula,re-laparotomy,re-thoracotomy,wound infection,arrhythmia,cardia failure,renal failure,hepatic inadequacy,cerbral infarction,and mortality(P > 0.05).There were also no significant differences in number of lymphonode and achievement ratio of periesophagel lymph nodes,subcarinal lymph nodes and hilar lymph nodes (all P > 0.05).Conclusion The thoracoscopic esophagectomy has some obvious advantage associated with less pulmonary complications,lower injury of thoracic duct and recurrent laryngeal nerve,more lymphonode and higher achievement ratio along the right recurrent laryngeal nerve lymphatic chains.But it has still a larger space for improvement of lymphadenectomy along the left recurrent laryngeal nerve lymphatic chains.
5.Strategies and technical key points of lymph node dissection along the left recurrent laryngeal nerve in robot-assisted esophagectomy
Xiaobin SHANG ; Xiaofeng DUAN ; Jie YUE ; Zhao MA ; Chuangui CHEN ; Chen ZHANG ; Dawang QU ; Hongjing JIANG
Chinese Journal of Digestive Surgery 2021;20(5):497-503
Esophagectomy and lymph node dissection are the cornerstones for the treatment of esophageal cancer. Upper mediastinal lymph node dissection is of great value for accurate staging and improving the prognosis of patients. Lymph node dissection along the left recurrent laryngeal nerve is the most challenging procedures in esophageal surgery, and there has been no relevant consensus on the scope and boundary of lymph node dissection. In recent years, with the application of endoscopic technology, especially robotic surgery system in esophagectomy, and the introduction of the concept of superior mediastinal microdissection, the authors have proposed the border of lymph node dissection along the left recurrent laryngeal nerve, so as to achieve precise, radical and standardized dissection. Combined with their own experiences, the authors elaborate on the anatomic boundary, extent and technique of lymph node dissection along the left recurrent laryngeal nerve.
6.Genotypes analysis of HPV infection in cervical cell samples among women in Xxuzhou region
Lin XIA ; Peiyao GONG ; Jianxiang GENG ; Hongjing WANG ; Jin TAN ; Wei XIAO ; Wenyuan MA ; Xiurong LONG ; Xue ZHAO
International Journal of Laboratory Medicine 2015;(7):882-884
Objective To investigate the distribution situation of human papillomavirus (HPV) genotypes profile in cervical cells among women in Xuzhou area and its clinical significance .Methods 23 kinds of HPV DNA were extracted in cervical cell samples from 8 010 women in Xiuzhou area .The gene‐chips technique of PCR combined with reverse dot blot was adopted to detect the HPV genotypes .Results Among 8010 cervical cell samples ,there were 1 852 HPV infected cases ,the total HPV infection rate was 23 .12% ,the HPV infection rates of single type accounted for 17 .17% and its predominant types were 16 type (4 .35% ) ,followed by 58 type (2 .12% ) and 52 type (1 .82% ) ,The detection rate of multiple HPV infection was 5 .96% ,in which the predominant types were HPV16+58(4 .40% ) ,16+52(2 .94% ) ,11+16(2 .52% ) .Conclusion The single HPV infection of HPV16 ,58 ,52 and the multiple HPV infection of HPV16+58 ,16+52 ,11+16 are the main genotypes of cervical cells among women in Xuzhou area , this gene chip technique is suitable for the cervical cell sample ,its once detection can detect 23 kinds of HPV genotypes with high specificity and high sensitivity ,which has an important significance for the molecular epidemiologic survey study of HPV genotypes distribution among women in our country .
7.Comparative study between thoracoscopic and open esophagectomy on perioperative complications and stress response.
Mingquan MA ; Hongjing JIANG ; Lei GONG ; Peng TANG ; Xiaofeng DUAN ; Xiaobin SHANG ; Zhentao YU
Chinese Journal of Gastrointestinal Surgery 2016;19(4):401-405
OBJECTIVETo compare the perioperative complications and the stress response between thoracoscopic esophagectomy and open esophagectomy in patients with esophageal cancer.
METHODSClinicopathologic data of 154 patients with esophageal cancer undergoing thoracoscopic esophagectomy (thoracoscope group) and 113 undergoing open procedure(open group) in the Tianjin Medical University Cancer Institute and Hospital from October 2012 to September 2014 were analyzed retrospectively. The incidence of perioperative complications and the change of stress response index in patients without complications were compared between two groups.
RESULTSThe total complication rate in thoracoscope and open group was 33.8% and 38.1%(P = 0.470) respectively. Compared with open group, incidence of ligation of thoracic duct(2.6% vs. 14.2%), recurrent laryngeal nerve paralysis (16.9% vs. 28.3%), chylothorax (0 vs. 4.4%), atelectasis (1.3% vs. 7.1%), pleural effusion (0.6% vs. 6.2%) and acute respiratory distress(0.6% vs. 6.2%) were obviously decreased in thoracoscope group(all P<0.05). No significant differences were observed in other complications (all P>0.05). Thirty-two cases and 24 cases without complication and with complete test data in thoracoscope and open group were selected for the detection of stress response index. There were no significant differences in white blood cell count, and the levels of cortisol, thyroxine (FT3 and FT4) and C-reactive protein between two groups at the same time points (before operation, 1, 3 and 6 days after operation) (all P>0.05).
CONCLUSIONThoracoscopic esophagectomy has some obvious advantages associated with less pulmonary complications, lower morbidity of injury in thoracic duct and recurrent laryngeal nerve, while no significant difference of stress response is found in patients without complication between thoracoscope group and open group.
Esophageal Neoplasms ; surgery ; Esophagectomy ; Humans ; Ligation ; Postoperative Complications ; Retrospective Studies ; Thoracoscopy
8. Lymph node metastasis and prognostic factors for T1 esophageal cancer
Xiaofeng DUAN ; Xiaobin SHANG ; Peng TANG ; Hongjing JIANG ; Lei GONG ; Jie YUE ; Mingquan MA ; Zhentao YU
Chinese Journal of Surgery 2017;55(9):690-695
Objective:
To evaluate the lymph node metastasis (LNM) pattern and related prognostic factors for T1 esophageal cancer.
Methods:
Clinical data of 143 cases of pT1 esophageal cancer patients (120 male and 23 female patients with median age of 60 years) who underwent esophagectomy and lymph node resection during January 2011 and July 2016 at the Department of Esophageal Cancer of Tianjin Medical University Cancer Institute and Hospital were reviewed, including 50 cases of T1a patients and 93 cases of T1b patients. The LNM pattern was analyzed and the prognostic factors related to LNM were assessed by χ2 test and Logistic regression analysis.
Results:
Of 143 patients, 25 patients had LNM. The LNM rates were 17.5% for pT1 tumors, 16.0%(8/50) for pT1a tumors, and 22.6%(21/93) for T1b tumors. Of 25 patients with LNM, one patient had cervical metastasis, 15 patients with thoracic metastasis, and 17 patients with abdominal metastasis. The relatively highest LNM sites were laryngeal recurrent nerve (8 cases), left gastric artery (8 cases), right and left cardiac (6 cases) and thoracic paraesophageal (5 cases). Logistic regression analysis showed that the depth of tumor infiltration (
9. Comparison of the prognostic value of the seventh and eighth edition of The AJCC Esophageal Cancer Staging System for the patients with stage Ⅱ and Ⅲesophageal squamous cell carcinoma
Hao ZHONG ; Rong MA ; Lei GONG ; Chuangui CHEN ; Peng TANG ; Peng REN ; Hongjing JIANG ; Zhentao YU
Chinese Journal of Surgery 2017;55(12):903-908
Objective:
To compare and evaluate the prognostic value of the 7th and 8th edition of
10.Legal aspects of pharmaceutical E-commerce development against the "Internet+" scenario
Hongjing WANG ; Wei WANG ; Youli HU ; Yong MA ; Shuhua WANG ; Jianhua ZHANG
Chinese Journal of Hospital Administration 2019;35(8):636-641
With the steady progress of the rule of law for Internet in China, " Internet+medicine" is drawing greater attention and legislative demand. The enactment of E-commerce Law in early 2019 has provided rich legal connotations of " Internet+" commerce scenario, clarifying its legal subject scope and legal service scope.The authors analyzed the legal system of medical E-commerce, and the legal obligations of medical E-commerce. From the following four aspects of legitimate business conduct, consumer rights protection, platform responsibility and intellectual property protection, the authors held that the current legal regulation of medical E-commerce is plagued by major setbacks as follows.These setbacks include incomplete legislation, low legal ranking, ambiguous subject definition and legal guidance, as well as lack of behavior regulation and unclear legal obligations.In this regard, the state is recommended to advocate the enactment of the Pharmaceutical E-commerce Law, speed up the revision of a series of laws and regulations, and improve the supporting service policies as a whole, so as to strengthen the rule of law regulation of future pharmaceutical E-commerce.