Objective To evaluate the diagnostic value of tuberculosis antibody. Methods 564 patients re-ceived detection of serum,in which,508 cases suffered from active tuberculosis(TB) and 56 cases suffered from non-active TB. Results 508 cases with active TB received detection AB-Ab in serum, 48 cases were bacteriological smear positive cases, the rate of serum TB-Ab positive cases was 70.8% (34/48), the rate of pleural effusion or ascites TB-Ab positive cases was 44.4% (16/36), the rate of serum TB-Ab positive cases in another 424 cases with bacteriologi-cal smear negative TB was 39.6% (168/424). There was significant difference between active TB group and non-ac-tive TB group(χ2= 22.65, P<0.01). Conclusion It is useful for diagnosis of active TB by detecting TB-Ab. It may be a rapid auxilliary diagnostic way in TB diagnosis.

ObjectiveTo evaluate the characteristics,treatment and prognosis of metachronous bilateral primary breast cancer(mBPBC). MethodsClinical materials of 48 patients were performed with retrospective study. ResultsIn 48 patients,43 cases taken both sides modified radical mastectomy and 5 cases taken lumpectomy and axillary dissection in the second side.All patients were treated with chemical treatment and treated with radiotherapy in accordance with lymph node metastasis.Besides a part of patients were treated with endocrine therapy in accordance with the expression of estrogen receptor(ER)and progesterone receptor(PR).The follow-up time was 6 ～ 48 months and the average time was 21.9 months.No died and 5 cases found distant metastasis. ConclusionmBPBC should be diagnosed earlier,taken appropriate treatment and followed up actively,so it would have a better therapeutic effect.

Objective To comparatively analyze the cognition and feelings of professional self-con-cept of nurse (PSCN) between nursing students and nursing staff and and to propose recommendations for the education of nursing students. Methods Professional self-concept of nurses instrument (PSCNI) scale was used to investigate the self evaluation of nursing students and nursing staff in the aspects of nursing skills, leadership, flexibility,satisfaction degree and communication skills. SPSS 19.0 was used to analyze the total scores and scores of each aspects; F test and t test were used to analyze the difference between two groups. Results Total score for nursing students and nursing staff were (81.27±7.40) points (67.7%) and (85.00±7.96) points (70.0%), with significant differences between the two groups (P=0.003). Scores in as-pects of nurturing skills, communication, flexibility were higher in nursing staff than in nursing students, with significant differences between the two groups (P<0.05). Conclusion The cognition and feeling of nursing staff is better than nursing students in aspects of nurturing skills, communication, flexibility. Nursing teaching can correspondingly improved based on the differences between the two groups.

Objective To observe and analyze the clinical efficacy of docetaxel and S-1 in treatment of anthracycline-resistant triple-negtive breast cancer(TNBC).Methods 64 cases with TNBC admitted in People' Hospital of Shaoxing City from June 2009 to June 2011were selected as research object.The clinical data of these cases were analyzed retrospectively.Anthracycline had been used to treat the cases, but with no effect or recurrence.Then docetaxel combined with S-1 was applied to the cases.Clinical efficacy and adverse reactions of the chemotherapy were observed and analyzed. Results After treatment,the efficiency of 64 cases was 54.69%,and the disease control rate was 79.69%.During the treatment,the main adverse reactions were gastrointestinal reactions and bone marrow suppression,without death,and patients could tolerate the adverse event.Follow-up results showed that the median time of progression was 10.5 months.After two years,progression-free survival rate was 0.Conclusion Docetaxel combined with S-1 has good clinical efficacy for anthracycline-resistant triple-negtive breast cancer,with relatively mild side effects,which may be an ideal adjuvant chemotherapy method.

[ABSTRACT]OBJECTIVETo analyze the risk factors and clinical curative effect of revision endoscopic sinus surgery.METHODSThe clinical data of the 80 patients underwent revision endoscopic sinus surgery were analyzed and the efficacy of the surgery was evaluated by the scores of the endoscopic examination, Lund-Mackay and VAS scoring system. Recovery rate and risk factors were observed and assessed. RESULTSIn 80 patients, 62 cases recovered, 11 cases improved, 7 cases were ineffective,and the total effective rate was 91.25%. Single factor analysis showed that operation frequency, follow-up compliance, history of allergic rhinitis and polyps effect on the clinical curative effect significantly (P<0.05). Multiple Logistic regression analysis showed that main risk factors affecting the curative effect were operation frequency, history of allergic rhinitis and polyps, follow-up compliance, VAS score, endoscopic examination scores, CT examination score, and nasal cavity adhesion (relative risk was between 1.4-2.8).CONCLUSIONOperation frequency, follow-up compliance, history of allergic rhinitis and polyps are important factors on curative effect of revision surgery.

Brain Neoplasms ; diagnosis ; surgery ; Child ; Female ; Humans ; Pterygopalatine Fossa

Background and purpose:Radiofrequency ablation (RFA) was one of the best combined treatments for hepatocarcinoma. CT was commonly used to evaluate treatment response and recurrent disease. However it was diffi cult to evaluate treatment effectiveness of RFA and to detect recurrent nodule especially the size below 1cm. Digital subtraction arteriography(DSA) may provide fi nal diagnosis of recurrent nodule after RFA for hepatocarcinoma. Our purpose was to analyze the signs of DSA after RFA for hepatocarcinoma in order to provide possible reference for treatment effectiveness and the imaging follow-up methods. Methods:17 patients with primary liver cancer (n=15) or hepatic metastasis(n=2) were enrolled in this study. Common hepatic arteriography or super-selective angiography of suspicious tumor area were performed on all patients. Results:On DSA, most ablated regions presented as round or ovoid low density areas with no stain. At the peripheral zone of the lesion, fi ve signs after RFA could be found: Stain of localized granulation tissue, arterio-portal fi stula, hemorrhage, recurrence and no abnormal fi ndings. Local or intrahepatic recurrence occurred in 9 cases. Conclusion:Hepatic DSA has great value in detecting local recurrence of hepatic tumor after RFA treatment. DSA is superior to CT in detecting marginal or intrahepatic recurrent nodule below 1 cm.

BACKGROUND: The marker of cartilage degeneration is a hotspot research in recent years. Collagen type II C-telopeptide (CTX-Ⅱ) is a good index which can detect cartilage degeneration through atraumatic method. OBJECTIVE: To observe the correlation of collagen CTX-Ⅱto intervertebral disc degeneration and osteoarthritis. DESIGN, TIME AND SETTING: Retrospective analysis. This subject was completed in the Department of Orthopedics of Zhengzhou University from March to June 2008. PARTICIPANTS: Fifteen patients with intervertebral disc degeneration, including 7 male and 8 female, with mean age of (62?7) years old, and 15 patients with osteoarthritis, containing 6 male and 9 female with mean age of (61?8) years old were selected. In addition, 15 patients (8 male and 7 female) without intervertebral disc degeneration or osteoarthritis, with mean age of (57?6) years old were served as the control group. METHODS: For each patient, fasting second-void morning urine samples were collected and stored at –20 ℃. After all the samples were collected, urinary CTX-Ⅱ was measured by enzyme-link immunosorbent assay. Meanwhile, the creatinine concentrations of each sample were detected for correct the CTX-Ⅱ. MAIN OUTCOME MEASURES: The content and the correlation of urinary CTX-Ⅱ in intervertebral disc degeneration patients and in osteoarthritis patients. RESULTS: A total of 45 patients were included in the final analysis. Compared with the control group, the content of urinary CTX-Ⅱ in intervertebral disc degeneration and osteoarthritis groups were higher, and the distinction had statistical significance (P 0.05). There was positive correlation of urinary CTX-Ⅱ to the grade of intervertebral disc degeneration and osteoarthritis (r=0.592, P=0.003). CONCLUSION: The content of urinary CTX-Ⅱ step up both in intervertebral disc degeneration patients and osteoarthritis patients. Urinary CTX-II has direct correlation with intervertebral disc degeneration and osteoarthritis.

Objective To evaluate the clinical application and safety of CT-guided transthoracic cutting needle lung biopsy in diagnosing diffuse lung diseases. Methods By using automatic biopsy gun (14 & 16 gauge), CT-guided transthoracic cutting needle lung biopsy was performed in 29 cases with diffuse lung diseases. The samples obtained were sent for pathological and immunohistochemical examination. The sampling successful rate, the diagnostic accuracy and the occurrence of complications were analyzed. Results Technical success rate was 100%, and large size of sample enough for pathological and immunohistochemical examination was obtained in all 29 cases. Definite pathological diagnosis could be made in 25 cases, with the positive diagnostic rate of 82.8%. The main complications included pneumothorax and pulmonary hemorrhage. The symptoms in most cases were not severe and disappeared within one week after the treatment. Conclusion For the diagnosis of diffuse lung diseases, CT-guided transthoracic cutting needle lung biopsy is a safe, easy, effective and reliable method with high successful rate, high diagnostic value and fewer complications, in these respects this technique is superior to transbronchial lung biopsy, open lung biopsy and video-assisted thoracoscopic lung biopsy. Therefore, this technique should be popularized in clinical practice.

Objective:To investigate the role of clinical pharmacists in the process of chemotherapy for a patient with intracranial glioma. Methods:Usage and dosage of antitumor drugs, drug interactions, adverse drug reactions and medication education after dis-charged as the breakthrough points, clinical pharmacists and clinicians explored options for the patient treatment and adjusted the medi-cation timely according to the condition. Results:There were no serious adverse drug reactions in the adjusted therapeutic regimen and the treatment results of the patient were satisfactory. Conclusion:Clinical pharmacists provide pharmaceutical care can play an impor-tant role in improving the safety and effectiveness of drug use.