Objective To investigate the efficacy and toxicity of infusion of chemotherapeutics through artery to treat advanced pancreatic carcinoma. Methods 46 patients with advanced pancreatic carcinoma were divided into experiment group ( n = 24) and control group ( n = 22). The way of administration of experiment group and control group were through artery or through vein respectively. Results Objective remission rate was 45.83% (11/24) clinical benefit rate was 58.33% (14/24) .median survival time was 16 months(from6 ～23months) in infusion-through-artery group, while those in infusion-through-vein group were18. 18% (4/22) ,27. 27% (6/22) ,7 months (from 3 -18months) respectively. All had significant diferences between two groups (P ＜ 0.05). Conclusion To treat patients with advanced pancreatic carcinoma,transarterial infusion chemotherapeutics was more effective,the toxicity was endurable.

Objective To investigate the value of magnetic resonance perfusion imaging in differentiating benign and malignant breast tumors.Methods The subjects were confirmed by magnetic resonance perfusion imaging in the diagnosis of breast lesions in 68 patients,and histopathologic examination of the control and analysis of its results.Results After perfusion weighted magnetic resonance imaging line parallel operation therapy,68 cases breast lesions in patients with pathologically confirmed,32 cases of benign tumor and malignant tumor in 36 cases;further observations on lesions of the morphology and dynamic enhanced performance,rendering their time-signal intensity curve,benign tumor type (inflow),type Ⅱ (platform) and type Ⅲ (clearance type) were 78.1％ (25/32),18.7％ (6/32),3.2％ ( 1/32),malignant tumor were 2.8％ ( 1/36 ),33.3％ ( 12/36 ),63.9％ ( 23/36 ),two groups had significant difference (P ＜ 0.05).Conclusion Mr T1 perfusion imaging for differentiating benign and malignant breast tumors have high application value,and has the advantages of simple operation,noninvasive advantages,worthy of clinical application.

ObjectiveTo observe and evaluate the efficacy of Clostridium Butyricum Powder for preventing childhood diarrhea after pneumonia. Methods176 infants with pneumonia were randomly divided into two groups,100 infants as prevention group, another 76 infants as control group. With normal antibacterial therapy,and two hours afterwards. Clostridium Butyricum Powder was administered at doses of 0.5g three times a day,in prevention group.After diarrhea taken place, Clostridium Butyricum Powder was administered at doses of 0. 5 g three times a day, in control group. Clinical effect and untoward effect were observed. ResultsThe incidence of pneumonia-induced diarrhea was 9% in prevention group,and was 46. 8% in control group( P < 0. 01 ). Duration of diarrhea and course of the treatment in prevention group as compared to those in the control group were statistically significant( P < 0. 01 ).Adverse reaction was not found. ConclusionClostridium Butyricum Powder can prevent diarrhea after pneumonia with antibacterial therapy.

Objective To compare the clinical effect and safety of two kinds of quadruple therapy on the basis of omeprazole and rabeprazole in the treatment of patients with active gastric ulcer and Hp positive.Methods 104 patients with active gastric ulcer and Hp positive were chosen,and they were randomly divided into two groups including A group (52 patients)with omeprazole treatment,and B group (52 patients)with rabeprazole treatment on the basis of amoxicillin +clarithromycin +bismuth potassium citrate.The clinical efficacy,clinical symptom remission rate in 7d,14d and 28d after treatment,HP eradication rate,recurrence rate with follow -up and adverse reaction inci-dence of 2 groups were compared.Results The clinical cure rate of B group was significantly higher than A group (36.54% vs.19.23%)(χ2 =8.74,P <0.05).There was no significant difference in the clinical total effective rate between the two groups(P <0.05).The clinical symptom remission rates in 7d and 14d after treatment of B group were significantly higher than A group(96.15% vs.76.92%,96.15% vs.78.85%,98.08% vs.82.69%;98.08%vs.84.62%,100.00% vs.82.69%,100.00% vs.88.46%)(χ2 =8.74,7.20,7.91;7.05,6.86,6.33;all P <0.055).The Hp eradication rate of B group was significantly higher than A group(92.31% vs.73.07%)(χ2 =9.24,P <0.05).The recurrence rate of B group was significantly lower than A group(7.69% vs.25.00%)(χ2 =10.62,P <0.05).The incidence rate of adverse reaction of B group was significantly lower than A group(3.85% vs. 13.46%)(χ2 =7.85,P <0.05).Conclusion Compared with omeprazole,quadruple therapy on the basis of rabe-prazole in the treatment of patients with active gastric ulcer and Hp positive can effectively relieve the digestive symp-toms,promote ulcer repair process,higher the Hp removal effects,prevent the long -term recurrence and is helpful to reduce the adverse drug reactions risk.

Objective To study the treatment efficacy and safety of transjugular filter implantation combined with dorsal venous pressure thrombolysis in the treatment of lower extremity deep venous thrombosis.Methods According to the random digital methods,80 patients with lower extremity venous thrombosis were divided into 2 groups,40 cases in each group.The observation group was given jugular vein filter implantation combined with dorsal venous pressured thrombolysis guided by the radiologic intervention,and control group was individually given the dorsal vein of foot pressure thrombolytic therapy.After treatment,the clinical effect was compared between the two group.Results The application of urokinase aggregates and thrombolysis time in the observation group were significantly lower than those in control group,thigh and calf circumferences reduced length before and after thrombolytic therapy in the observation group increased significantly than those in the control group(t =1.35,5.42,1.83,0.89,all P ＜ 0.05).The total effective rate of the control group was 60％,which was significantly lower than that of the observation group 85％ (x2 =3.85,P ＜0.05).The incidence rate of complication in the control group was 32.50％,that in the observation group was 30％,there was no statistically significant difference between the two groups(x2 =0.67,P ＞ 0.05).Conclusion Transjugular filter implantation combined with dorsal venous pressure thrombolysis in the treatment of lower extremity venous thrombosis has better efficacy and safety.

Objective To investigate the changes of disease activity and clinical significance in the course of treatment in patients with SLE.Method 286 cases of SLE were reviewed and compared the changes of SLEDAI scores in different disease duration.Results The SLEDAI scores of patients whose first treatment courses less than 1 month and 1 to 3 months were significantly lower than those patients whose were 4 to 6 months and more than 6 months. After treatment for 2 months to 3 years, the SLEDAI scores were not correlated with cumulated dosage of corticosteroids.Conclusions For the patients of short first treatment course, the treatment could relieve SLE disease activity rapidly and effectively to some extent; while for the patients whose first treatment courses were relatively long ,the relif of disease activity was relatively slow. After treatment for 2 to 3 months, the disease of SLE patients was more active than other periods, and it was inclined to produce visceral damage. As mentioned above ,we should pay attention to this phenomenon.

The wireless real-time monitoring system for body temperature is based on electronic thermometry and wireless communication technology. It can measure and store the patient's body temperature during the desired time span, and can transmit the data to the computer terminal or the cell phone terminal through wireless transmission system.

Objective To investigate the expression and significance of S100A4 protein and Ecadherin in coloreetal carcinoma. Methods S-P immunohistochemical method was used to detect the expression of S100A4 and E-cadherin in 87cases with colorectal carcinoma and 87 cases with adjacent colorectal tissue, and the expression of S100A4 and E--cadherin were analyzed with relation to clinicopathologic factors and post-operative five-year survival. Results There was no expression for S100A4 protein in glandular epithelium of adjacent colorectal tissues. The positive expression rate of S100A4 was 64.4 %(56/87) in colorectal carcinoma. There was a significant difference between eolorectal carcinoma and adjacent group(P ＜0.01). The expression of S100A4 was positively correlated with the clinical stages, lymph node metastasis and five-year survival (P ＜0.05), but not with other clinicopathalagic factors (P ＞0.05). There was 100 % expression for E-cadherin in adjacent colorectal tissues. The positive expression rate of Ecadherin was 62.1%(54187) in colorectal carcinoma. There was a significant difference between colorectal carcinoma and adjacent group (P ＜0.01). The expression of E-cadherin was positively correlated with the clinical stages, lymph node metastasis, tumor site and five-year survival (P ＜0.05), hut not with other clinicopathologic factors (P ＞0.05). The expression of S100A4 was negatively correlated to E-cadherin in colorectal carcinoma without statistical meaning(r =-0.087, P ＞0.05). Conclusion S100A4 and E-cadherin are closely related with colorectal cancer invasion, metastasis and prognosis; S100A4 might be an important predictor of the clinicopathologic features and prognosis of eolorectal carcinoma.

Objective To explore the relationship between pressure source and mental healthy of freshmen in medical college. Methods 1324 freshmen in medical college were assessed with Beck-Srivastava stress inventory (BSSI) and checklist 90 (SCL-90) to detect the pressure source and mental health state. Relative analysis and regression analysis was used to statistic differences. Results The BSSI total score was from 49 to 119,mean score was (77.68 ± 12.47 )of freshmen in medical college. It was obviously higher than critical pressure.The 6 factors score of SCL-90 in somatization, compulsion, interpersonal relationship, depression, anxiety and hostility were significantly higher than Chinese domestic norms, the difference has a statistical significant (P ＜0. 01 ). The 7 factors score of somatization, compulsion, interpersonal relationship, depression, anxiety, hostility and fear in male freshmen were higher than those in female freshmen, the difference has a statistical significant (P＜ 0. 05 or P＜ 0.01 ). Relative analysis and regression analysis results showed that 5 factors of BSSI entered the regression equaltion. Conclusion The mental health problems of freshman in medical college were relatively serious, and the college should be pay special attention to the problem and intervene early.

Objective To investigate whether baicalein inhibits the proliferation, cell cycle of and pseudopod formation in A431, a skin squamous cell carcinoma cell line, by suppressing the expression of ezrin protein. Methods A431 cells were grouped to be transfected with ezrin-targeting siRNA (siRNA group), treated with baicalein of 5, 10, 20, 40 μmol/L, respectively (baicalein group), or remain untreated (control group). After additional culture, wound healing assay and Transwell assay were performed to observe the migration and invasion of A431 cells, RT-PCR to detect the mRNA expression of ezrin in A431 cells, Western blot and immunoflu-orescence to measure the expression of ezrin protein and its phosphorylation. The pseudopod formation in A431 cells was observed by using scanning electron microscopy. Results After 24-hour culture, wound healing assay displayed that the percent wound closure was 13.3 ± 1.7, 7.6 ±1.6 and 5.9 ± 1.3, respectively, in A431 cells treated with baicalein of 5, 10, 20μmol/L, significantly lower than that in untreated A431 cells (16.3 ± 2.3, all P < 0.01), and the inhibition of baicalein on the migration of A431 cells was concentration-dependent. In the Transwell assay, a significant decrease was observed in the number of A431 cells per high power field permeating through the artificial basement membrane in the groups treated with baicalein of 5, 10, 20 μmol/L for 48 hours compared with the control group (46.5 ± 3.8, 34.3 ± 3.4, 25.3 ± 2.3 vs 56.3 ± 3.8, all P < 0.01), whereas no significant difference was noted between these baicalein-treated groups and siRNA-transfected group (28.3 ± 2.1, all P > 0.05). RT-PCR analysis showed that the mRNA expression of ezrin in baicalein-treated A431 cells significantly decreased compared with that in untreated cells (all P< 0.01), but showed no difference from that in siRNA group (P > 0.05). A statistical difference was also observed in the expression of ezrin and phosphorylated ezrin protein between baicalein-treated A431 cells and untreated cells (all P< 0.05), but not between 40 μmol/L baicalein-treated A431 cells and siRNA-transfected cells (P> 0.05). Furthermore, the suppression of baicalein on ezrin protein and mRNA expression was concentration dependent. The number of pseudopod per cell was significantly lower in 20 μmol/L baicalein-treated A431 cells and siRNA-transfected cells than that in untreated A431 cells (5.3 ± 1.9, 4.5 ± 2.8 vs 22.6 ± 2.8, both P < 0.01), while no significant difference was observed between the former two groups of cells (P > 0.05); the length of pseudopodia also reduced in baicalein-treated cells. Conclusions Baicalein may inhibit the proliferation and invasion of A431 cells by directly or indirectly suppressing the expression of ezrin and phosphorylated ezrin, which in turn contributes to the effect of baicalein against tumor proliferation and metastasis.