To study the effect of compressible limb sleeve system on tumefaction of limbs and recurrence of thrombus in patients underwent venous thrombectomy of deep venous thrombosis (DVT). Sixty-two patients underwent venous thrombectomy of DVT between September 2004 and July 2005 were selected from Affiliated Hospital of Luzhou Medical College, and then were randomly divided into the experimental group and the control group. Patients in the control group were given usual care after the surgery, while patients in the experimental group were treated by compressible limb sleeve system based on usual care (once a day and 30 minutes each time. 14 days were taken as one course, and there were totally 2 courses). The circumference, recurrence rate of thrombus and warmth sensation of affected limb were observed before and after the treatment in both groups. Detection at 28 days after the treatment showed that the circumference of patients in the experimental group decreased, and the score of warmth sensation decreased. There were significant differences in comparison with those in the control group before the treatment (P

OBJECTIVE:To observe clinical efficacy and safety of Danning tablets combined with endoscopic ligation in the treatment of esophageal varices in patients with nonalcoholic fatty liver cirrhosis(NFLC). METHODS:A total of 70 NFLC patients with esophageal varices in our hospital during Sept. 2015-Sept. 2016 were divided into control group and observation group by simple random sampling method,with 35 cases in each group. Both groups received endoscopic ligation. Control group was given Somatostatin for injection with intravenous pump at the speed of 250 μg/h for 72 h after surgery,and Pantoprazole sodium enteric-coated capsules 40 mg,qd. Observation group was additionally given Danning tablets 1 g,tid,on the basis of control group. Both groups were given medicine for consecutive 4 weeks.The situation of ligation and clinical efficacies were observed in 2 groups,and the grading of esophageal varices before and after treatment,the occurrence of re-bleeding events and ADR were observed. RESULTS:The patients of 2 groups completed ligation successfully,there was no statistical significance in the times of ligation between 2 groups(P>0.05). Total response rate of observation group was 91.43%,which was significantly higher than 74.29% of control group,with statistical significance(P<0.05).Before treatment,there was no statistical significance in the grading of esophageal varices between 2 groups(P>0.05). One month and three months after treatment,the grading of esophageal varices in 2 groups were significantly better than before treatment,and observation group was significantly better than control group,with statistical significance(P<0.05). There was no statistical significance of 2 groups between 3 months after treatment and one month after treatment(P>0.05).Total incidence of re-bleeding events in observation group was 14.29% within 3-month follow-up,which was significantly lower than 40.00% of control group,with statistical significance(P<0.05). There was no statistical significance in the total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Danning tablets combined with endoscopic ligation show significant therapeutic efficacy for esophageal varices of NFLC,significantly mitigate the degree of esophageal varices and reduce the incidence of re-bleeding without increasing the occurrence of ADR.

Objective:To analyze the effect of hospital-community-family health management on self-efficacy and quality of life (QoL) assessments in discharged patients with nephrotic syndrome (NS).Methods:A total of 102 NS patients who received treatment at the Department of Nephrology in the Affiliated Hospital of Southwest Medical University from January 2018 -January 2019 were selected, and randomized to intervention or control group. The intervention and control group implemented hospital-community-family health management and routine health management for 6 months, respectively. In addition to serum biochemistry and routine urine tests, the general self-efficacy scale (GSES) and QoL (by short form-36 questionnaire; SF-36) assessments were performed in both groups and compared.Results:The levels of 24-hour urine protein, serum creatinine (Scr), blood urea nitrogen (BUN) and plasma albumin, and the GSES and SF-36 assessments were comparable between groups at baseline ( P>0.05). Levels of 24-hour urine protein, Scr and BUN were found to be significantly lower ( P<0.05) in the intervention group than the control group (1.50±0.42 vs. 1.90±0.61 g/L, 152.35±20.31 vs. 185.36±15.59 μmol/L, 7.89±2.01 vs. 10.32±2.35 mmol/L, respectively); however, the intervention group showed a significant increase ( P<0.05) in plasma albumin levels as compared to the control group (32.35±4.48 vs. 29.85±4.35). The intervention group reported significantly higher ( P<0.001) GSES score than the control group (3.00±0.56 vs. 2.45±0.45 points), indicating a better ability of patients in the intervention group to cope up with the daily routine activities. The post-intervention scores of the individual domains, namely overall health, physiological function, physical pain, energy, and mental health, in the SF-36 questionnaire were significantly higher ( P<0.001) in the intervention group than the control group (57.01±4.31 vs. 53.10±4.60 points, 70.06±5.61 vs. 64.02±5.50 points, 65.01±4.31 vs. 61.01±4.80 points, 65.41±5.40 vs. 60.42±5.12 points, 74.40±6.80 vs. 65.42±7.12 points, respectively), implying a better health status in the intervention group. Conclusions:The implementation of hospital-community-family health management during the post-discharge home recuperation period of NS patients can improve their biochemical parameters and QoL, and boost their confidence in the performance of daily routine activities.

Objective:To explore the short-term clinical efficacy, safety and patients' prognostic influencing factors of CyberKnife for the treatment of brain metastases in non-small cell lung cancer (NSCLC).Methods:A retrospective case series study was conducted. The clinical data of 58 NSCLC patients who received CyberKnife treatment for brain metastases at Jilin Cancer Hospital from July 2020 to January 2022 were retrospectively analyzed. At 3 months after CyberKnife treatment for brain metastases, and the efficacy of radiotherapy was evaluated on the basis of changes of brain metastases detected by contrast-enhanced magnetic resonance imaging (MRI) of the head. Overall survival (OS) and local recurrence-free survival (LRRFS) were analyzed in 58 patients by using the Kaplan-Meier method; the efficacy of cumulative brain metastasis volume for determining the survival of CyberKnife-treated NSCLC patients with brain metastases was analyzed by using the receiver operating characteristic (ROC) curve with the survival status of patients during the follow-up period as the gold standard, and the optimal cut-off value of cumulative brain metastasis volume was obtained; the clinical factors affecting OS and LRRFS of CyberKnife-treated NSCLC patients with brain metastases were analyzed by univariate and multivariate Cox proportional hazards models, and the adverse reactions associated with CyberKnife treatment were evaluated.Results:Among the 58 patients, 26 (44.8%) were male and 32 (55.2%) were female, with a median age [ M ( Q1, Q3)] of 64 years old (56 years old, 70 years old); there were 1-7 brain metastatic lesions in each patient, and there were 98 brain metastatic lesions in the 58 patients. There were 2 deaths (3.4%) within 3 months after CyberKnife treatment. At 3 months after treatment, there were 3 cases (5.4%) in complete remission, 36 cases (64.3%) in partial remission, 13 cases (23.2%) in stable disease, and 4 cases (7.1%) in disease progression in the remaining 56 patients. ROC curve analysis showed that the area under the curve for determining the survival of CyberKnife-treated NSCLC patients with brain metastases based on the cumulative brain metastasis volume was 0.593 (95% CI: 0.423-0.763), and the optimal cut-off value of cumulative brain metastasis volume was 15 cm 3. Median follow-up time was 12.6 months (7.5 months, 17.9 months). The 6- and 12-month OS rates were 91.3% and 79.5%, respectively, and the 6- and 12-month LRRFS rates were 93.0% and 89.2%, respectively. Multivariate Cox regression analysis showed that the Karnofsky functional status score (>70 points vs. ≤70 points, HR= 0.103, 95% CI: 0.019-0.545, P = 0.007), control of extracranial tumor (controlled vs. uncontrolled, HR = 0.145, 95% CI: 0.049-0.429, P < 0.001), cumulative brain metastasis volume (≤15 cm 3vs. >15 cm 3, HR = 0.105, 95% CI: 0.028-0.399, P = 0.001) were independent influencing factors for poor OS, and the control of extracranial tumor (controlled vs. uncontrolled, HR = 0.062, 95% CI: 0.006-0.616, P = 0.018), cumulative brain metastasis volume (≤15 cm 3vs. >15 cm 3, HR = 0.440, 95% CI: 0.007-0.292, P = 0.001), and target area total bioequivalent dose (BED) (≤60 Gy vs. >60 Gy, HR = 5.299, 95% CI: 1.020-27.530, P = 0.047) were independent influencing factors for poor LRRFS. Only grade 1-2 headache [53.5% (31/58)], nausea and vomiting [36.2% (21/58)] and other adverse reactions occurred after treatment, and no ≥grade 3 adverse reactions occurred. Conclusions:CyberKnife treatment for NSCLC brain metastases has high local control rate and short-term survival rate with mild adverse effects. Karnofsky functional status score, control of extracranial tumor and cumulative brain metastasis volume may affect OS of CyberKnife-treated NSCLC patients with brain metastases, and the control of extracranial tumor, cumulative brain metastasis volume and total BED may affect local recurrence.