1.The clinical value of MSCT in diagnosis of internal abdominal hernia
Hongfa CAI ; Ying CHEN ; Shuangqing CHEN ; Yuying SHEN ; Haihua SHI
Journal of Practical Radiology 2015;(3):420-423
Objective To investigate the clinical value of multi-slice spiral CT (MSCT)in diagnosis of internal abdominal hernia (IAH).Methods The MSCT findings in 1 5 patients with IAH confirmed by surgery were retrospectively analyzed.Results MSCT showed intestinal obstruction in 14 patients with strangulating intestinal obstruction in 8.The typical features of MSCT were as follows:translocated position of intestines (occupying effect),closed loop intestinal obstruction (gathered intestinal loops with different forms),assembled,expanded and translocated blood vessels of mesenteries,and thickened intestinal walls with ischemic edema and abnormal density.Surgical results showed paraduodenal hernia in 2,transomental hernia in 2,transmesenteric hernia in 5,ankylenteron strap hernias in 4,pericecal hernia in 1 and hernia through the Douglas fossa in 1,Intestinal obstruction in 14 and strangulating intestinal obstruction in 8 were also confirmed by surgery.The CT findings of IAH were correlated with the surgical results,and the accurate rate of grading of intestinal obstruction with CT was also consistent with the surgical results (Kappa=0.758,t=3.462,P=0.001).Conclusion IAH can be diagnosed accurately by MSCT in most patients,MSCT is helpful for guiding the surgical programs.
2.Structure and performance of calcium polyphosphate for bone tissue engineering.
Kai QIU ; Yuanwei CHEN ; Qi ZHANG ; Hongfa SU ; Xixun YU ; Changxiu WAN
Journal of Biomedical Engineering 2006;23(6):1271-1274
Porous calcium polyphosphate (CPP) has shown promise of tissue engineered implant application because of the biocompatibility and biodegradation. CPP with different polymerization degree were prepared by controlling the calcining time, and its polymerization degree could be calculated by developed method in this paper. Different crystal types CPP were prepared by quenching from the melt and crystallization of amorphous CPP. From the in vitro degradation, carried out in Tris-HCl buffer, the degradation velocity of CPP was controllable. The weight loss of CPP with different polymerization degrees and crystal types were different. With the increasing of polymerization degree, the weight loss during the degradation was decreasing, contrarily the strength of CPP was increasing. The amorphous CPP could degrade completely in 17 days while gamma-CPP do completely in 25 days. The degradation velocity beta-CPP and alpha-CPP was slower than gamma-CPP and the weight loss was about 12% and 5% respectively. The results of this study indicate that CPP have potential applications for bone tissue engineering as inorganic polymeric biomaterials.
Absorbable Implants
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Biocompatible Materials
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chemistry
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Bone Substitutes
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chemistry
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Calcium Phosphates
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chemistry
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Humans
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Tissue Engineering
3.Bone transport with unilateral external fixation for treatment of massive tibial bone defects
Mingheng LI ; Mouzhang HUANG ; Gongqun CHEN ; Rongping ZHU ; Hui YING ; Hongfa ZHONG
Chinese Journal of Orthopaedic Trauma 2023;25(11):999-1002
Objective:To analyze the clinical efficacy of bone transport with unilateral external fixation in the treatment of massive tibial bone defects.Methods:A retrospective study was conducted to review the 21 patients with massive tibial bone defects who had been treated by bone transport with unilateral external fixation from February 2017 to January 2022 at Department of Trauma Orthopedics, Ganzhou People's Hospital. There were 14 males and 7 females with a mean age of (46.3 ± 11.3) years. Causes for bone defects: trauma ( n=5), resection of bone non-union ( n=9), resection of infected bone ( n=6) and resection of bone tumor ( n=1). The mean bone defect length was (8.3 ± 1.7) cm. Bone transport started from 10 to 12 days after operation, with a speed of 1 mm/d, and was completed in 4 times. X-ray films were reviewed every 2 weeks. The bone union time, external fixation time (EFT), external fixation index (EFI), docking site situation and complications were recorded. The clinical efficacy was assessed by Paley score. Results:All patients were followed-up for a mean time of (13.5 ± 5.5) months. The mineralization of regenerated bone was good. The bone union time was (9.6 ± 2.2) months, the EFT (10.3 ± 4.0) months, and the EFI (1.3 ± 0.4) months/cm. All docking sites got united. The docking sites were cleaned in 14 patients, of whom simple compression with external fixation was performed in 5 and bone grafts at the docking sites in 9. Postoperative nail tract infection was observed in 6 cases, tibial alignment deviation in 1 case, foot drop deformity in 5 cases, horseshoe varus foot deformity in 1 case, toe flexion deformity in 3 cases, and refracture after removing the external fixation in 1 case. By the Paley score, the bony outcomes were rated as excellent in 16 and as good in 5 cases. The functional outcomes were excellent in 10, good in 7, and acceptable in 4.Conclusion:Bone transport with unilateral external fixation is an effective treatment for massive tibial bone defects, showing advantages of easy operation and convenient carry.
4.Discussion on the Industry Development Status of Blumea balsamifera Based on Patent Analysis
Xiaoli XIE ; Zhenxia CHEN ; Fulai YU ; Yuxin PANG ; Xuan HU ; Hongfa CHEN
China Pharmacy 2021;32(10):1158-1164
OBJECTIVE:To understand the current situation and existing problems of Blumea balsamifera industry in China , and to provide reference for its sustainable development . METHODS :With the keywords of “B. balsamifera ”“Ai Pian ”“Ai Fen ”, etc.,through the patent platform of SooPat and Baiten ,the patent data of B. balsamifera that had been published from Jan. 1989 to Dec. 2019 were collected. The International Patent Classification (IPC)was used to sort out and count the patent information of B. balsamifera,to understand the development status of B. balsamifera industry in technology and research field ,to analyze the existing problems and to explore the development trend of B. balsamifera industry in China so as to put forward corresponding suggestions. RESULTS & CONCLUSIONS:A total of 690 patents related to B. balsamifera were collected ,mainly invention patents,of which the authorization rate was 27.39%,the effective rate was 17.97%,and the failure rate was 55.22%. Top 10 applicants with the largest number of applications had a total of 165 applications,accounting for 23.91% of the total number of applications. Top 10 applicants were 4 enterprises,3 natural persons and 3 colleges and universities. The patents of B. balsamifera were mainly distributed in Guizhou ,Shandong,Anhui,Guangdong,Guangxi and Hainan ,accounting for 81.01% of the total patent applications of B. balsamifera . The patent technology field of B. balsamifera had expanded from traditional Chinese medicine to daily chemical products ,health care and physiotherapy and other daily consumer good fields. From the perspective of patent intensity,the number and quality of patent applications were not coordinated ,and there were many meaningless patent applications,and the conversion rate was low. It is suggested that China should strengthen the research on B. balsamifera and its more compatible medicinal materials ,promote the innovation ,development,transformation and upgrading of B. balsamifera industry;strengthen the systematic and in-depth research on B. balsamifera,improve the quality and conversion rate of patent xiexiaoli13@126.com technology,and revitalize the development of B. balsamifera industry; expand multi-party cooperation , strengthen the E-mail:fulai.yu@163.com research on patent core technology ,build the strategic alliance of intellectual property rights of B. balsamifera industry,and realize the high quality development of B. balsamifera industry.
5. Analysis on key points for construction of trauma emergency center of Jiangxi Province
Yuanlin ZENG ; Haiming CHEN ; Lisheng LUO ; Xianlai XU ; Haigang XU ; Zhili LIU ; Sheng LIU ; Bin FU ; Xuefeng HUANG ; Zhongping YUAN ; Lidong WU ; Yuhua WAN ; Youjia TANG ; Chunming HUANG ; Peng RAO ; Hongfa ZHONG ; Bohe LI ; Yongan ZHANG ; Jiahua TANG ; Bo YOU
Chinese Journal of Trauma 2019;35(12):1126-1129
Trauma is the leading cause of death for people under 40 years old in the world. At present, the rescue and treatment system of trauma patients in China is not yet well established, and the mortality of trauma patients is higher than those in the developed countries. Improving the treatment system is the key to reducing the trauma mortality. In order to innovate the service mode of trauma first aid, further promote the establishment of regional trauma first aid system, improve the ability of trauma treatment, reduce the mortality and disability rate of trauma patients in Jiangxi Province, recently Health Commission of Jiangxi Province and the First Affiliated Hospital of Nanchang University have reached a consensus on the establishment of Jiangxi trauma first aid center. In order to provide reference for the construction of trauma treatment system, the author analyzes the following aspects including functional positioning, basic requirements, organization management, and evaluation of core indicators.