Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. It is characterized by demyelination and axonal degeneration. This article is a comment on the limitation and progress of clinical diagnosis, classification and medication for MS. At present, there is insufficient understanding of MS in China, with low diagnosis rate, high misdiagnosis rate and non-standard treatment. In order to better understand and deal with MS, attention should be paid to the classification and corresponding therapy of MS.