OBJECTIVE To study the changes in trace elements Zn and Cr and cell immunologic function among elderly inpatients with lower respiratory tract infection.METHODS The changes in T-lymphocyte subpopulation and trace elements Zn and Cr in plasma and red blood cell of 52 inpatients with lower respiratory tract infection were compared with a control group of 53 healthy people of the same age group.The flame atom absorbing was for blood Zn testing,the non-flame atom absorbging for blood Cr testing the indirect immunofluorescent technique was for measurement of T cell subpopulation.RESULTS Among elderly inpatients with lower respiratory tract infection the ratio of Zn [(12.68?3.26)?mol/L] and Cr [(0.033?0.029)?mol/L] in plasma and Zn [(124.12?36.55)?mol/L] and Cr [(0.412?0.025)?mol/L] in RBC was significantly lower than control group [(17.39?4.78)?mol/L] and [(0.068?0.036)?mol/L],[(145.33?20.12)?mol/L] and [(0.666?0.038)?mol/L],respectively,the function of T-lympholyte subpopulation was reduced and in disorder,CD3 [(50.48?7.62)%],CD4 [(27.36?9.37)%] and CD4/CD8(0.67?0.23) was significantly lower than control group [(64.33?4.82)%,(42.35?8.12)% and(1.57?0.22)%],respectively,while CD8 [(35.37?7.55)%] was significantly higher than control group [(28.13?1.35)%],the statistical differences were significant(P

Chemotherapy is one of the primary treatments for cancer patients,while tumor multidrug re-sistance( MDR) represents a major obstacle in the treatments of patients,limiting the efficacy of chemotherapy.To date,the mechanism of drug resistance has not been fully elucidated.lncRNAs are a family of long noncoding RNAs that regulate gene expression by epigenetic modification,transcription and post transcriptional processing. Recent studies have showed that the aberrant regulation of target genes by lncRNAs may be involved in the acqui-sition of tumor MDR.Therefore,targeting lncRNAs may be an attractive strategy for improving the chemosentivity and reversing chemotherapeutic resistance.This paper reviews the relationship between lncRNAs and tumor drug resistance as well as the underlying possible mechanism.

Objective To compare the difference of clinical characteristics between patients with pituitary corticotroph macroadenoma and microadenoma. Methods From 1985 to 1998, 76 inpatients with Cushing′s disease, 12 cases of macroadenoma and 64 cases of microadenoma were reviewed. The clinical manifestations, the course before diagnosis, blood routine, biochemical and endocrinic examinations were retrospectively analyzed. Results Defect of vision field and galactorrhea were more frequent and the duration of disease before diagnosis were shorter in macroadenomas than those in microadenomas. Lymphopenia, hypokalaemia, lower creatine kinase level and hyperphosphoroemia were also more pronounced in macroadenomas. In macroadenomas, the plasma ACTH and cortisol (F) concentrations at 0:00 were obviously higher than those in microadenomas, but plasma ACTH and F at 8:00 and 24h urinary free cortisol were similar in these two groups. The relative nyctohemeral variation of ACTH was less in macroadenomas than that in microadenomas, the relative nyctohemeral variation of F was similar in these two groups. One month after operation, clinicl manifestations of macroadenomas significantly improved, but the number of these patients with significant blood ACTH decrease was significantly less than that in microadenomas. Conclusion Due to higher amount and automatism of ACTH secretion, increased blood F level induces variation of clinical characteristics and laboratorial findings in patients with macroadenoma compared to the patients with microadenoma.

Objective: To determine the relationship between resilience and social support among primary school students.Methods: 2 067 primary school students from grade 3 to 5 were surveyed with questionnaires of Social Support Questionnaire and the Student Resilience Survey revised from the California Healthy Kids Survey in Hefei. Results: (1) The average scores of resilience of students in Hefei were 49.0?8.8, Girls got higher scores (50.1?8.6) than boys on resilience(47.9?8.8,t=5.71, P

Objective:To study the prevalence of depressive symptom and related factors among urban primary school students in Hefei.Methods:2,078 primary school students were surveyed with questionnaires including Children's Depression Inventory and items of social support and life style.Results:The prevalence of depressive symptom was 11.9%,the rate of boys was significant higher than that of girls(13.6%/9.6%,?2=7.01,P

Objective To observe the therapeutic effect of Laparescopic Cholecystectomy(LC) on acute calculous cholecystitis.Methods The data from 35 patients receiving laparoscopic cholecystectomy for acute calculous cholecystitis were analyzed.Results Successful rate of operation was 100% in all cases with no complications such as biliarducy injury,intestines damage and hemorrhage taken place,and mortality was 0%.Conclusion LC is safe for treatment of acute calculous cholecystitis.

Objective To investigate molecular epidemiology profile of methicillin-resistant Staphylococcus aureus (MRSA) in ICU ward.Methods Twenty-five MRSA strains were typed by arbitrarily primed PCR (AP-PCR).Results Ten different AP-PCR patterns (A-G) were found among 25 MRSA strains.Most of MRSA in ICU ward were A and B pulsotype.Conclusion Hospital acquired MRSA is multi-resistant to antibiotics.A and B pulsotype MRSA outbreak occures in ICU ward.

Objective To know the sanitary status of waterworks for centralized water supply in Anhui province,and try to enhance the implementation Standards for Drinking Water Quality (GB 5749-2006).Methods From April to November in 2008,the hygienic status and water quality self-test capacity of the waterworks at city,county,enterprise and town levels were investigated.Results As for the source water,over 70% of waterworks were up to the Grade Ⅲ standard.In the hygienic management and water treatment process,the city level water workswere better.The rates of complete water treatment were 80.63%,73.78%,58.12% and 60.46%,respectively for different level water works.The rates of the water quality test equipments fulfilled were 77.77%,42.99%,38.18% and 13.77% respectively.For water quality test,the 119 waterworks only focused on the aesthetic,general chemical and microbiological indexes.The performance rates of toxicological indicators,disinfectants indicators,radioactive indicators and other indicators were 17.65%,26.68%,15.97% and 3.49%,respectively.Conclusion Hygienic management of waterworks of levels for centralized water supply in Anhui province needs to be strengthened,and the water treatment process needs to be improved,the capacity building for self-test of water quality in the waterworks needs to be enhanced.

At present, the particularity and importance of ethical consciousness in the teaching of clinical obstetrics and Gynecology has become increasingly prominent while the education of medical students in the ethics and social responsibility is relatively weak. This study explored a series of practical methods under WEIGHT guide through the real cases, conducting clinical training and sides debate, com-bining multimedia and interview form, in order to strengthen the cultivation of medical students' moral quality and improve the students' comprehensive ability.

Purpose:To investigate palitaxel (Tax) induct io n of apoptosis in human retinoblastoma Y79 cells and the role of Bcl-2 phosphor ylation in the mechanism. Methods:Antiproliferation effects of Tax on Y79 cells were dete rmined by 3H-thymidine incorporation. Apoptosis of the Tax-treated cells was determined by DNA fragmentation analysis. Bcl-2 phosphorylation was determ ined by Western blot analysis. Cell transfection was used in mutant Bcl-2 trans fecting in Y79 cells. Results:After 24 hours treatment with 1 ?mol/L Tax, 3H- thymidine incorporation decreased in Y79 cells and the effects were time and dos e dependent. DNA ladder appeared in DNA fragmantation analysis after 12-24 hour s treatment with Tax. Bcl-2 Phosphorylation was significantly increased in 12- 24 hours treatment with Tax. Bcl-2, a mutant of Bcl-2, blocked Tax activation process. Conclusions:Tax inhibits cell growth and induces apoptosis in h uman Y79 cells, and phosphorylation of Bcl-2 might be involved in this process.