Wildtype p53-induced phosphatase 1 (Wip1) is a serine/threonine protein phosphatase of 605 ami-no acids, which is expressed at high levels in many organs and tissues .As Wip1 is overexpressed in human tumors , analy-sis of Wip1 has focused primarily on its role in tumorigenesis .In recent years , it has also been shown that Wip 1 plays an important role in several physiological processes including adult neurogenesis , senescence , immunodeficiency and metabolic diseases.This review addresses how Wip1 participates in physiological and pathological conditions at cellular and molecular levels.

Primitive neuroectodermal tumor (PNET) is a small round cell malignancies, normally confined to the chest wall and soft tissues of children and young adults, and reports of this tumor existing in nasal cavity are scarce. We herein present a case of nasal PNET. A 35-year-old male patient presented with a chief complaint of stuffy nose was diagnosed with a primary nasal pPNET by the clinical, microscopic, immunohistochemical features. Since these tumors are highly aggressive and patient prognosis is typically very poor, early diagnosis, immediate surgical resection and re-resection if possible, early radiotherapy and chemotherapy and close follow-up are required. We also review literatures on pPNET.
Adult ; Humans ; Male ; Neuroectodermal Tumors, Primitive ; pathology ; Nose Neoplasms ; pathology ; Paranasal Sinuses ; Prognosis

Otitis media with effusion (OME), a kind of inflammatory disease of the middle ear, is characterized by the retention of middle ear effusions and hearing loss. There are many factors involved in the development of OME including bacterial infection, formation of bacterial biofilms, eustachian tube dysfunction, adenoid hypertrophy, immune system disorders. Recently, some studies showed that gastroesophageal reflux has correlation with OME.
Adenoids ; pathology ; Bacterial Infections ; complications ; Biofilms ; Ear, Middle ; pathology ; Gastroesophageal Reflux ; complications ; Hearing Loss ; complications ; Humans ; Hypertrophy ; complications ; Otitis Media with Effusion ; complications

Cardiomyopathies ; Crystallins ; Humans

Objective:To investigate the biological characteristics of dental epithelial cells derived from cervical-loop epithelium in rat lower incisor. Methods:The apical end of the lower incisor was dissected from two-day-old Sprague-Dawley rats by visual microscopy, and dental epithelial cells were obtained by culture of the apical end explants of the lower incisor. The biological characteristics of dental epithelial cells were determined by morphology and immunocytochemistry fluorescence. Results:Dental epithelial cells emigrated from the cervical loop of rat lower incisor, and epithelium-like morphologies with round-shape or square-shape was observed. Dental epithelial cells had a striking proliferation potential with a high level of BurdU labeling. As a marker of epithelium stem cells, P63 expression was observed in most early cultured cells. However, as cells were subcultured, dental epithelial cells,with the lower level of BurdU labeling,decreasing expression of P63 and increasing expression of alkaline phosphatase, were inclined to terminal differentiation.Conclusion:Stem cells or dental epithelial progenitor cells might reside in the cervical loop of the apical end of the rat lower incisor. The present study may provide an excellent cell source for study on the differentiation of dental epithelial cells and tooth regeneration.

0.05).There was a littel difference in the costs for an identical effect between two drugs,the cost of Risperidon being lower.CONCLUSION:The total effective rates and costs of Risperidon and Clozapine were almost equal in the treatment of schizophrenia.

Objective To analyse frequency, risk factors and prognosis of stent thrombosis after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) during the last five-year period. Methods Primary PCI was performed in 311 patients with STEMI including 250 males and 61 females with an average age of 60.4 years (26～85 years). The standard triple antiplatelet/anticoagulation therapy with aspirin and clopidogreal plus heparin was used pre- and post-interventional procedure. All patients underwent more than two months follow-up investigation. Results A successful primary PCI procedure was achieved in 99% (308/311) STEMI patients with incidence of total stent thrombosis in 2.6% (8/308), including acute stent thrombosis in five patients and subacute or late thrombosis in three patients. Multiple risk factors could be identified in all the eight patients, of whom, three died of acute closure events and the follow-up study in the other five showed severe systolic dysfunction of left ventricle. Conclusion High incidence of stent thrombosis occurred after primary PCI for STEMI with high mortality and poor clinical prognosis. Application of small diameter and/or long stents and discontinuation of clopidogreal seem to be major risk factors.

Objective To study the effect of Atorvastatin on the level of serum high-sensitivity C-reactive protein(hs-CRP) and nitric oxide(NO) in patients with acute cerebral infartion(ACI). Methods 60 patients with ACI were randomly divided into the Atorvastatin therapy group (n=30) and the conventional therapy group (n=30). At the basic of conventional therapy, the Atorvastatin therapy group was treated with Atorvastatin 20 mg/d. Both groups were treated for 14 consecutive days. The levels of serum hs-CRP and NO were measured and the scores of neurological deficit (NDS) were evaluated before and after treatment. Results The levels of serum hs-CRP in both two groups after 14 d treatment were significantly lower than those before treatment ( all P