1.The unreasonable use of high beam at nighttime among motor vehicle drivers
GUO Lihua ; ZHONG Jieming ; LI Na ; HU Yunqing ; WU Zhongding ; ZHU Hongting ; HE Chunlei ; ZHAO Ming
Journal of Preventive Medicine 2021;33(8):784-788
Objective:
To observe the incidence of unreasonable use of high beam at nighttime among motor vehicle drivers, so as to provide the evidence for the prevention and control of road traffic injury.
Methods:
Four roads into city and five urban roads were selected in Yongkang of Zhejiang Province. An automatic recording system was used to collect the unreasonable use of high beam among motor vehicle drivers on the selected roads from 19:00 to 5:00 on Monday, Wednesday, Friday and Sunday during a week in July 2020. The regression tree model was used to analyze the relationship of the unreasonable use of high beam with road, time and traffic flow.
Results:
A total of 89 989 motor vehicles were observed, and 2 419 motor vehicle drivers had unreasonable use of high beam, with an incidence rate of 2.69%. The incidence rate of the unreasonable use of high beam was 3.14% in the roads into city, which was higher than 2.30% in the urban roads ( P<0.05 ). The incidence rates of the unreasonable use of high beam in the roads into city and in the urban roads were 5.15% and 2.90% on Wednesday, which were higher than those on Monday ( 2.89% and 2.34% ), Friday ( 2.90% and 1.92% ) and Sunday (2.06% and 2.12%). The highest incidence rate of the unreasonable use of high beam in the roads into city was 6.07% between 4:00 and 5:00, and in the urban roads was 4.50% between 2:00 and 3:00. The results of regression tree classification analysis showed that the highest incidence rate was 8.13% on the roads into city in the east, west and south directions, and on the urban roads in the east and north directions with less than 317 vehicles per hour on Wednesday.
Conclusion
It is more likely for motor vehicle drivers to use high beams unreasonably at nighttime on the roads into city with less traffic flow.
2.Research advances in biomarkers for early diagnosis of acute aortic dissection
Hongting ZHAO ; Shuang GAO ; Qingguo LI ; Hao YAO
International Journal of Surgery 2019;46(3):190-194
Acute aortic dissection (AAD) is a potentially catastrophic cardiovascular disease,with significant morbidity and mortality,and it remains a challenge to diagnose and treat.Survival rate has been shown to be directly related to prompt diagnosis and precise management,it is necessary for early diagnosis and treatment.However,diagnosis of the disease relies heavily on various imaging techniques,remaining time-consuming and difficult to obtain.Nevertheless,the application of biomarkers provides a new direction for the diagnosis of AAD.Therefore,the application of biomarkers with high specificity and sensitivity contribute to optimal treatment to reduce the mortality rate is the current research direction.This article was to summarize the domestic and abroad research advances which focused on the biomarkers and progress of aortic dissection.
3.Recent advance in role of macrophage migration inhibitory factor in the central nervous system
Jing YANG ; Yueqian ZHU ; Hongting ZHAO ; Hao YAO
Chinese Journal of Neuromedicine 2019;18(9):952-956
Macrophage migration inhibitory factor (MIF) is involved in a variety of physiological and pathological processes. Pathological increase of MIF is sufficient to promote inflammation, aggravate metabolic dysfunction, and increase oxidative stress. MIF inhibition, through either gene knockout or pharmacological inhibitors, is clinically beneficial for treatment. Ironically, both detrimental and beneficial effects of MIF have been reported in ischemic stroke, neurodegenerative diseases, and spinal cord injury; thus, the roles of MIF appear to be bidirectional in the central nervous system. In the current review, we focus on the roles of MIF in the central nervous system, as well as its regulating mechanisms.
4.Status analysis of underreporting in the direct online reporting system of infectious diseases in private medical institutions
Qing WANG ; Hongting ZHAO ; Dan LIU ; Yunting XIA ; Shan WANG ; Xiaohong JIANG
Chinese Journal of Hospital Administration 2020;36(8):634-638
Objective:To understand the missing report rate and reporting status of infectious diseases in private medical institutions and discuss the defects involved, so as to provide a scientific basis for further standardizing the management of infectious disease reporting.Methods:By virtue of onsite data collection and face-to-face interview of 16 private hospitals in Chaoyang district of Beijing from January to May 2019, which were equipped with direct network report system, qualitative and quantitative data of their current infectious disease reporting were collected. Ratio or constituent ratio indicators was used to describe sample characteristics and survey indicators, while the ratio or constituent ratio were compared via χ2 test. Results:The missing report rate of these hospitals was 11.73%. Top three infectious diseases neglected were acute hemorrhagic conjunctivitis(100.00%), genital herpes(100.00%)and viral hepatitis(96.36%). The missing report rate of inpatients was higher than that of outpatients, and that of chronic infectious diseases was higher than that of acute infectious diseases. These hospitals were found with such defects as insufficient training of infectious disease diagnosis, and poor self-inspecting regulations and poor management actions.Conclusions:The missing reports rate of infectious diseases was high among private hospitals in Chaoyang district, especially that of chronic infectious diseases. It is necessary to strengthen infectious disease diagnosis training, and further standardize the infectious disease reporting process in hospitals using the electronic information systems, so as to reduce underreporting and consolidate infectious disease prevention and control in hospitals.
5.Research progress between hypoxia inducible factors and osteoarthritis
Hongting SHEN ; Mingjun WANG ; Qiang LI ; Zhijun ZHAO
Chinese Journal of Endemiology 2020;39(2):154-156
Hypoxia-inducible factors (HIFs) play an important role in development, formation, regeneration and metabolism of extracellular matrix among bone and cartilage. Osteoarthritis (OA) is caused by many reasons, which result in degeneration and damage of joint cartilage and reaction regeneration of joint margin and subchondrobone. The etiology of OA remains uncertain; the relationship between HIFs and OA could provide scientific data for OA prevention and control.
6.Plasma microfibrillar associated protein 5 level in patients with polycystic ovary syndrome
Mingyu LIAO ; Xing LI ; Huan ZHAO ; Weixin LI ; Liu SHI ; Xiuli WANG ; Hongting ZHENG ; Min LONG
Chinese Journal of Endocrinology and Metabolism 2022;38(1):30-35
Objective:To assess plasma microfibrillar associated protein 5(MFAP5) level in patients with polycystic ovary syndrome(PCOS), and to explore its relationship with glucose and lipid metabolism as well as sex hormones.Methods:Fifty PCOS patients and 65 healthy female subjects were selected as PCOS group and control group, respectively. Clinical data and plasma MFAP5 levels between the two groups were compared.Results:The plasma MFAP5 level in PCOS group was significantly higher than that in control group( P<0.01), and the plasma MFAP5 level in PCOS overweight subgroup was higher than that in control subgroup( P<0.01). No difference was observed in plasma MFAP5 level between the two non-overweight subgroups( P>0.05). Correlation analysis showed that plasma MFAP5 level was positively correlated with waist circumference, low density lipoprotein-cholesterol, fasting insulin, homoeostasis model assessment of insulin resistance index(HOMA-IR), HbA 1C, testosterone, LH/FSH ratio, and leukocyte( P<0.05 or P<0.01). There was no significant correlation of MFAP5 with body weight, body mass index(BMI), hip circumference, waist hip ratio, high density lipoprotein-cholesterol(HDL-C), triglyceride, total cholesterol, and blood glucose( P>0.05). In PCOS group, plasma MFAP5 level was positively correlated with body weight, BMI, waist circumference, hip circumference, total cholesterol, and leukocyte( P<0.05 or P<0.01). There was no significant correlation of MFAP5 with waist hip ratio, HDL-C, triglyceride, blood glucose, fasting insulin, HOMA-IR, leukocyte, and sex hormones( P>0.05). Multivariate logistic regression analysis showed that MFAP5 was an independent risk factor for PCOS( P<0.05). Conclusion:Plasma MFAP5 level is increased in PCOS patients and is closely related to BMI, waist circumference, hip circumference, and total cholesterol. Plasma MFAP5 is an independent risk factor for PCOS, which may be involved in the pathogenesis of PCOS.
8.Distribution and infectious characteristics of re-positive cases infected with SARS-CoV-2.
ZhiLi LI ; Yu LI ; QiuLan CHEN ; XiaoKun YANG ; HongTing ZHAO ; XinLi JIANG ; SiMeng FAN ; Dan LI ; Ying QIN ; ZhiBin PENG ; JianXing YU ; NaiYing MAO ; ZhongJie LI
Chinese Journal of Epidemiology 2021;42(10):1750-1756
Domestic and foreign literatures related to the persistence of SARS-CoV-2 and the re-positive cases infected with SARS-CoV-2 were reviewed, and the characteristics and infectivity of the re-positive cases were analyzed to provide scientific evidence for the improvement of case management and the development of measures to stop the spread of SARS-CoV-2. Existing studies have shown that re-positive rate of SARS-CoV-2 ranged from 2.4% to 19.8%, the median of interval between re-positive detection and discharge was 4-15 days. Following the second course of the disease, the anti-SARS-CoV-2 IgM, IgG and IgA positive rates of the cases were 11.11%-86.08%, 52.00%-100.00% and 61.54%-100.00% respectively, the total antibody and neutralizing antibody positive rates were 98.72% and 88.46%. The viral load of the re-positive cases was lower than that in the initial infection. At least 3 380 re-positive cases have been reported globally. SARS-CoV-2 strains were isolated from the samples of 3 re-positive cases (1 immunodeficiency case and 2 cases with abnormal pulmonary imaging). There were close contacts that were infected by an asymptomatic case taking immunosuppressive agents. In conclusion, the infectivity of re-positive cases infected with SARS-CoV-2 is generally very low. Rare re-positive cases infected with SARS-CoV-2 might cause further transmission. The management approach for the re-positive cases can be based on the assessment of the individual transmission risk according to the pathogen detection results.
Antibodies, Neutralizing
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Antibodies, Viral
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COVID-19
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Humans
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Immunoglobulin M
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SARS-CoV-2