Self-directed learning(SDL)is an important learning form for the future educational development and the continued medical education.SDL facilitates the learning effects of advanced studying doctors in neonatology.This article investigates the major developments and influencing factors relative to self directed learning,and provides insight into the practice and progress of self directed learning of the advanced studying doctors in neonatology.

Acute Disease ; Adult ; Benzene ; poisoning ; Humans ; Male ; Multiple Organ Failure ; chemically induced ; Occupational Diseases ; complications

Objective To explore effects and mechanism of inactivation of vitamin D receptor (VDR) in intestinal tumor growth of APCmin/+ mice. Methods To generate APCmin/+VDR -/- mice through breeding, the number and size of small intestinal and colonic tumors were assessed and compared between APCmin/+ and APCmin/+ VDR -/- mice. The intestinal tumors were diagnosed with HE stain. The expressions of BCL-2,vimentin-1,Stat-1 and MSH-2 proteins of tumors were determined by immanohistocbemistry and compared be-tween APCmin/+ and APCmin/+VDR -/- mice. Results A comparison between APCmin/+ and APCmin/+ VDR -/- mice revealed that the number of the tumors, which were larger than 3mm, was significantly increased in APCmin/+ VDR -/- mice at 4 months of age (P< 0.01). HE staining indicated fistulous adenomas from small intestine and colon of two groups, Immunostaining showed Stat - 1 level in APC-min/+ tumors were increased and MSH-2 and vimentin-1 levels in APCmin/+ VDR-/- mice were increased, compared to APCmin/+tumors. Conclusion These observations suggested that inactivation of VDR promoted the intestinal tumor growth of APCmin/+ mice.

Hepatic stem cells transplantation might be an important treatment strategy for patients with end stage liver diseases and related research has become a focus of recent studies.Hepatic stem cells of different sources have great therapeutic potential in clinical practice,but much research still need to be done before it can be used as a routine method in clinical practice. This review discusses the characteristics of hepatic stem cells and its role in liver regeneration after liver damage.

Cell Line, Tumor ; Humans ; Matrix Metalloproteinase 2 ; analysis ; Matrix Metalloproteinase 9 ; analysis ; Melanoma ; enzymology ; Skin Neoplasms ; enzymology

Objective To investigate the function and possible mechanism of acupuncturing “Zusanli” point on the liver cell membrane of rat with chronic alcohol liver injury. Methods Chronic alcoholic liver damage rat model was established by 60% ethanal intragastric infusion for 60 d. Total phosphatide, total cholesterol and phosphatide component were determined. Result Compare with the normal recovery group, acupuncture “Zusanli” point can increase the content of PC and PE, decrease the content of Chol and SM of liver cell, and reduce the membrane aging index C/P, SM /PC. Conclusion Acupuncture “Zusanli” point has the function of protecting the liver cell membranes and improving the liver cell membrane’s fluidity of chronic alcohol liver injury rat.

Humans ; Occupational Exposure ; prevention & control ; Respiratory Protective Devices ; classification ; standards ; utilization ; United States

This article elucidates the relationship between the human susceptibility to obesity and gene polymorphisms such as peroxisome proliferators-activated receptors(PPARs)and PPAR?coactivator-1,along with milestones in the formation and development of capacity for fat deposition during evolutionary history of human.An biological evolutionary analysis,identifying factors favoring the energy stores,may be helpful to the development of preventive public health strategies.

· AIM: To study the expression of basic fibroblast growth factor (bFGF) receptor protein in human lens epithelial cells (HLECs). METHODS: Immunohistochemistry was used to detect the level of bFGF receptor protein and image analysis was adopted to perform the relative quantitative analysis on it. · RESULTS: There was bFGF receptor protein in HLECs accordingl to both qualitative and quantitative analysis. · CONCLUSION: bFGF receptor protein exists in HLECs and it is the material foundation for bFGF to improve the proliferation of HLECs.

Objective To explore clinical features and pregnancy outcomes of early-ouset severe pre-eclampsia. Methods Clinical data of 96 cases of severe preeclampsia who deliveried in Southeast University from November 2004 to February 2009 were analyzed. The patients were divided into two groups, early-onset preeclampsia group(onset gestatioual weeks <34) and later-onset preeclampsia group(onset gestatianal weeks≥34 ). Resnits Significant difference of two groups were found in central nervous system symptom and urine protein (+ +) or > 2 g/24 h (P<0.05), incidence of abnormal prenatal outcome (χ~2=14.792,4.741,27.03 respectively;P<0.05). Mean birth weight in early-onset preeclampsia group (1743.86±630.34)g was lower than that in later-onset pre-eclampsia greup(2940.47±762.36)g (t=6.71 ,P<0.05). Conclusions Clinical symptoms of early-onset severe preeclampsia are severe , and have a higher incidence of abnormal prenatal outcomes. Prevention, prediction ,diagno-sis and management of preeclampsia are important for mothers and children.