1.Successful treatment in 46 cases of acute poisoning .
Su-hui SU ; Cheng-ming GEO ; Hong-ten LI
Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(4):291-292
Acute Disease
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Adolescent
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Adult
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Benzene
;
poisoning
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Cough
;
etiology
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Dexamethasone
;
therapeutic use
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Fatigue
;
etiology
;
Female
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Glucocorticoids
;
therapeutic use
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Glutathione
;
therapeutic use
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Humans
;
Length of Stay
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Male
;
Middle Aged
;
Occupational Diseases
;
etiology
;
therapy
;
Occupational Exposure
;
adverse effects
;
Treatment Outcome
2.Prospective audit of post-chemotherapy febrile neutropenia in patients with solid cancer and lymphoma in two Singaporean cancer centres.
Mabel WONG ; Jing JIN ; Min Han TAN ; Yee Mei LEE ; Ten Eng LEE ; Ying DING ; Hong Chan YONG ; Siew Eng LIM ; Louis Ya CHAI ; Noan Minh CHAU ; Li Yang HSU
Annals of the Academy of Medicine, Singapore 2012;41(7):287-293
INTRODUCTIONFebrile neutropenia (FN) is a significant cause of mortality and morbidity in oncology and haematology units worldwide. The overall mortality in hospital surveys in Singapore surveys on post-chemotherapy FN has ranged between 3.0% and 8.8%. However, recent evidence indicates that outpatient management of patients with low-risk FN is safe and cost-effective.
MATERIALS AND METHODSWe conducted a prospective audit on a cohort of adult patients with post-chemotherapy FN seen at 2 local public sector cancer centres over a 1-year period in order to define their epidemiological characteristics and outcomes, and also to assess the uptake of early discharge/outpatient management strategies for these patients.
RESULTSWe reviewed 306 FN episodes from 248 patients. Patient characteristics and outcomes were similar between both institutions. Eleven (3.7%) FN episodes were managed as outpatient and none developed complications. Overall 30-day mortality was 6.6%, while the median length of stay (LOS) was 7 days (IQR: 4 to 11 days). The only independent risk factor for mortality was severe sepsis (OR:13.19; 95% CI: 1.98 to 87.7; P = 0.008). Factors independently associated with a longer LOS were vancomycin prescription (coefficient: 0.25; 95% CI: 0.08 to 0.41; P = 0.003), longer duration of intravenous antibiotics (coefficient: 0.08; 95% CI: 0.06 to 0.10; P <0.001), and prior review by an infectious diseases physician (coefficient: 0.16; 95% CI: 0.01 to 0.31; P = 0.034).
CONCLUSIONThis audit demonstrated that mortality from FN in our 2 cancer centres is low and comparable to international institutions. It also demonstrates that outpatient management of FN is safe in selected patients, and can be further expanded for right-siting of resources.
Adult ; Anti-Bacterial Agents ; therapeutic use ; Antineoplastic Agents ; adverse effects ; Bacterial Infections ; epidemiology ; Cohort Studies ; Female ; Fever ; epidemiology ; etiology ; Humans ; Male ; Middle Aged ; Mycoses ; epidemiology ; Neoplasms ; complications ; drug therapy ; Neutropenia ; epidemiology ; etiology ; Prospective Studies ; Singapore ; epidemiology