Objective To study the radiosensitization effects of tetrandrine on advanced non small cell lung cancer and its toxicity.Methods The patients of 82 cases with advanced non-small cell lung cancer were confirmed by pathology or cytology.The first course of treatment was treated with radiation therapy.Patients were divided into three groups:tetrandrine group,paclitaxel group and radiotherapy group.Tetrandrine group(30 cases)took radiotherapy with 40 mg tetrandrine(3 times a day)from the first day to the ending.Paclitaxel group (29 cases)took radiotherapy with intravenous infusion of 60 mg paclitaxel(once a week).Radio-therapy group (23 cases)only received radiotherapy.Results Tetrandrine and paclitaxel had the same radiosensitizing effect in ra-diotherapy.The total effective rate of tetrandrine and paclitaxel group was higher than radiotherapy group (P <0.05 ).The inci-dence of radiation pneumonitis in tetrandrine group was significantly lower than the other two groups (P <0.05).The one year free disease survival rate was promoted in tetrandrine group than other groups.Conclusion Tetrandrine was known as the same radia-tion sensitizing effect of paclitaxel fairly,which can reduce the toxicity of radiotherapy.

Blood-Brain Barrier ; physiopathology ; Brain Injuries ; physiopathology ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Inflammation ; complications ; Oxygen ; metabolism

Child ; Humans ; Liver Diseases ; Mitochondrial Diseases

Age Factors ; Child ; Diagnosis, Differential ; Humans ; Polymerase Chain Reaction ; Prader-Willi Syndrome ; diagnosis ; genetics ; therapy ; Prognosis ; Treatment Outcome

Female ; Growth Hormone ; therapeutic use ; Humans ; Infant ; Prader-Willi Syndrome ; diagnosis ; drug therapy ; genetics

Child ; China ; Humans ; Rheumatic Diseases

0.05).3.Thirty-three point three percent of animals from parental strain group were found fibrillations potentials and the po-sitive sharp waves in gastrocnemius electromyogram,no obvious abnormal waves were found in animals from both waaF mutant and control group.Conclusions The ganglioside-like epitope in LOS of CJ is critical antigen in inducing GM1-IgG antibody and in inducing conduction block of peripheral nerve,therefore,provide a support for the molecular mimicry theory as a pathogenesis in the axonal GBS following CJ infection.

Objective To explore the relationship between tumor necrosis factor(TNF)-? promoter G238A,G308A and interferon(IFN)-?+874A/T polymorphism and susceptibility to cytomegalovirus(CMV) hepatitis.Methods A TaqMan fluorescence polymerase chain reaction(PCR) in the IFN-?+874A/T and TNF-? gene promoter region single nucleotide polymorphism was tested in the subjects,including 87 infants with CMV hepatitis and 89 children without CMV hepatitis.Results No evident difference of TNF-? +238G/A and+308G/A allele frequency was found between infants with CMV hepatitis and controls.The cases of IFN-?+874 AA,AT and TT genotype were 64,20,3 cases in the infant CMV hepatitis group,and 45,26 and 18 cases in the control group,respectively.There was significant difference in IFN-?+874 allele genotype and frequency between infants with CMV hepatitis and the control group(P=0.001,P

AIM: To investigate the role of retinal pigment epithelium (RPE) in the growth of Müller cells using a co-culture system in vitro . METHODS: Müller cells were cocultured with RPE cells under both normoxic and hypoxic conditions in Transwell chamber culture system. Müller cell proliferation was evaluated by MTT assay. The number of cells which migrate through micropores and stay on the outer bottom side of insert systems were observed and counted. RESULTS: The activities of proliferation and migration of Müller cells when cocultured with RPE cells were significantly higher than those of the Müller cells when cultured alone at all time points under both normoxic and hypoxic conditions. However, for both the coculture and control groups, there is no significant difference between the measurements at 3 and 6 hours. CONCLUSION: Evidence suggests that RPE, when co-cultured with Müller cells, can stimulate migration and proliferation of Müller cells under both hypoxic and normoxic conditions in a time-dependent manner; how-ever, there is no evidence to support the synergetic interaction of RPE and Müller cells co-cultured under hypoxic conditions.

Autoimmune Diseases ; diagnosis ; immunology ; pathology ; surgery ; Humans ; Immunoglobulin G ; blood ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pancreatectomy ; Pancreatitis ; diagnosis ; immunology ; pathology ; surgery