Objective To study the radiosensitization effects of tetrandrine on advanced non small cell lung cancer and its toxicity.Methods The patients of 82 cases with advanced non-small cell lung cancer were confirmed by pathology or cytology.The first course of treatment was treated with radiation therapy.Patients were divided into three groups:tetrandrine group,paclitaxel group and radiotherapy group.Tetrandrine group(30 cases)took radiotherapy with 40 mg tetrandrine(3 times a day)from the first day to the ending.Paclitaxel group (29 cases)took radiotherapy with intravenous infusion of 60 mg paclitaxel(once a week).Radio-therapy group (23 cases)only received radiotherapy.Results Tetrandrine and paclitaxel had the same radiosensitizing effect in ra-diotherapy.The total effective rate of tetrandrine and paclitaxel group was higher than radiotherapy group (P <0.05 ).The inci-dence of radiation pneumonitis in tetrandrine group was significantly lower than the other two groups (P <0.05).The one year free disease survival rate was promoted in tetrandrine group than other groups.Conclusion Tetrandrine was known as the same radia-tion sensitizing effect of paclitaxel fairly,which can reduce the toxicity of radiotherapy.

Diagnosis, Differential ; Family Health ; Genetic Predisposition to Disease ; genetics ; Glomerulonephritis, IGA ; diagnosis ; genetics ; HLA Antigens ; genetics ; Humans

Humans ; Infectious Disease Transmission, Vertical ; prevention & control ; Kidney Diseases ; prevention & control ; virology ; Viruses ; pathogenicity

Child ; Connective Tissue Diseases ; complications ; diagnosis ; therapy ; Humans ; Hypertension, Pulmonary ; diagnosis ; etiology ; therapy

Chronic Disease ; Forkhead Transcription Factors ; Hepatitis, Viral, Human ; Humans

Antibodies, Antiphospholipid ; immunology ; therapeutic use ; Antiphospholipid Syndrome ; diagnosis ; immunology ; therapy ; Child ; Humans

Female ; Growth Hormone ; therapeutic use ; Humans ; Infant ; Prader-Willi Syndrome ; diagnosis ; drug therapy ; genetics

Insulin resistance and insulin secretion deficiency are main machanisms in inducing type 2 diabetes mellitus (T2DM), and mitochondria damage plays an important role in them. Research shows that autophagy is a self-protective mechanism of cells, which plays an important role in maintaining the normal structure and function of pancreatic β cells and improving insulin resistance. Previous studies show that traditional Chinese medicine can regulate cell autophagy to influence β cells and insulin resistance, type 2 diabetes mellitus and its complications. Thus this review will talk about the process of the relationship between autophagy and T2DM and the intervention effect of traditional Chinese medicine.
Animals ; Autophagy ; drug effects ; Diabetes Mellitus, Type 2 ; drug therapy ; metabolism ; physiopathology ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Insulin ; metabolism ; Insulin Resistance ; Insulin-Secreting Cells ; cytology ; drug effects ; metabolism

AIM: To investigate the role of retinal pigment epithelium (RPE) in the growth of Müller cells using a co-culture system in vitro . METHODS: Müller cells were cocultured with RPE cells under both normoxic and hypoxic conditions in Transwell chamber culture system. Müller cell proliferation was evaluated by MTT assay. The number of cells which migrate through micropores and stay on the outer bottom side of insert systems were observed and counted. RESULTS: The activities of proliferation and migration of Müller cells when cocultured with RPE cells were significantly higher than those of the Müller cells when cultured alone at all time points under both normoxic and hypoxic conditions. However, for both the coculture and control groups, there is no significant difference between the measurements at 3 and 6 hours. CONCLUSION: Evidence suggests that RPE, when co-cultured with Müller cells, can stimulate migration and proliferation of Müller cells under both hypoxic and normoxic conditions in a time-dependent manner; how-ever, there is no evidence to support the synergetic interaction of RPE and Müller cells co-cultured under hypoxic conditions.