1.Wolfram syndrome: report of one case.
Hong-hua LIN ; Shan HUA ; Cheng WU
Chinese Journal of Pediatrics 2011;49(6):470-470
Adolescent
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Humans
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Male
;
Wolfram Syndrome
2.Report of a case with methylmalonic acidemia.
Hong-hua LIN ; Cheng WU ; Yang DONG
Chinese Journal of Pediatrics 2008;46(7):557-558
4.Catathrenia: a case report.
Wei WANG ; Hong-hua LU ; Peng LIN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(9):773-774
Adolescent
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Humans
;
Male
;
Parasomnias
6.Bilateral laryngeal granulomas after endotracheal intubation.
Zhi-hong LIN ; Hua-lin WANG ; Hui-e WANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2007;42(1):67-68
Adult
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Aged
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Female
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Granuloma, Laryngeal
;
etiology
;
Humans
;
Intubation, Intratracheal
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adverse effects
;
Male
7.Effect of speech therapy on mental health of patients with aphasia
Xu HE ; Jun HONG ; Jian-hua LIN ; Ling QIU
Chinese Journal of Rehabilitation Theory and Practice 2002;8(11):694-695
ObjectiveTo investigate the effect of speech therapy on mental health of patients with aphasia. MethodsCRRCAE and SCL-90 were used to assess the speech and mental state in 28 aphasia patients. All aphasia patients were treated by using speech therapy and the changes before and after treatment were compared. ResultsThe scores in listening comprehension, repetition, naming, reading,reading comprehension, writing and counting were distinctly higher at post-treatment than that at pre-treatment. All SCL-90 factor's levels at post-treatment were distinctly reduced than that at preat post-treatment(P<0.01).Conclusions Speech therapy can improve the language function,as well as mitigate the mental symptoms.
9.Comparison of three different molecular assays for the detection and molecular characterization of circulating tumor cells in breast cancer
Changrui SUN ; Jun DENG ; Lin FENG ; Hua HONG ; Yongmei JIANG
Chinese Journal of Laboratory Medicine 2015;(10):666-671
Objective Comparison of three different molecular assays for the detection and molecular characterization of circulating tumor cells in breast cancer .Methods The retrospective study compared three different molecular assays to detect CTC in the peripheral blood of 30 healthy individuals and 71 benign breast disease patients and 83 early and 84 metastatic breast cancer patients .All samples were collected at the outpatient , inpatient and physical examination department of Sichuan Provincial People ′s Hospital from January 2011 to June 2014.The same cDNAs were analyzed by:singleplex RT-qPCR assay for BCL-2, multiplex RT-qPCR for BCL-2, HER-2, HMAM, and a commercially available molecular assay (AdnaTest BreastCancer ) for GA733-2, MUC-1, HER-2.The positive of CTC were compared among healthy individuals and benign breast disease patients and breast cancer patients .Chi square test was used to compare the expression of gene markers among the three groups , and the agreement of Kappa test was used to evaluate the method.Results (1) Detection rates of early breast cancer by single RT-qPCR, Adna kits and multiple RT-qPCR were 13.3%, 16.9% and 18.1%, respectively , and the detection of metastatic breast cancer were 31.0%, 42.9%and 35.7%, respectively.There were significant differences in the positive of CTC by three molecular assays between healthy individuals and benign breast disease patients and early breast cancer patients ( The test values were 4.235 and 4.301, 5.367 and 5.474, 5.894 and 6.023 respectively, P<0.05).There were no differences between benign breast disease patients and early breast cancer patients (The test values were 0.891,0.748 and 0.701 respectively,P >0.05) .There were significant differences between metastasis breast cancer patients and healthy individuals and benign breast disease patients and early breast cancer patients ( The test values were 8.429,7.553 and 7.061;10.24, 9.025 and 8.745; 9.658, 8.417 and 8.201 respectively,P<0.05).(2) In early breast cancer: The concordance between AdnaTest and single RT-qPCR was 79.5%while between AdnaTest and multiplex RT-qPCR was 77.1%.No agreement was found among them ( The test values were 1.065 and 1.871, P were 0.371 and 0.258 ) .The concordance between single RT-qPCR and multiplex RT-qPCR was 80.7%.No agreement was found between them (The test values was 2.814, P was 0.156).(3) In patients with overt metastasis:The concordance between AdnaTest and single RT-qPCR was 78.6%( The test values was 10.986).While between AdnaTest and multiplex RT-qPCR was 80.9%( The test values was 9.251 ) . Agreements were found among them ( P was 0.002 and 0.005 respectively ) .The concordance between single and multiplex RT-qPCR was 88.1%( The test values was 12.364 ) .Agreement was found between them (P was 0.001).Conclusions No correlations were found among different molecular methods to detect CTC in the early primary breast cancer , but correlations were found in the metastatic breast cancer , suggesting that different rate of CTC caused by the number of CTC and its heterogeneity should be considered to the clinical diagnosis and treatment of breast cancer while molecular method is used .
10.Treatment of upper ureteral stones with spiral stone dislodger combined with pneumatic lithotriptor under ureteroscopy
Hong HUANG ; Meixia LIN ; Hua TANG ; Jian CHEN ; Shiyong HUANG
Chinese Journal of Primary Medicine and Pharmacy 2005;0(11):-
Objective To evaluate the effectiveness of spiral stone dislodger combined with pneumatic lithotriptor under ureteroscopy for managing upper ureteral stones. Methods 106 patients with upper ureteral stones with spiral stone dislodger combined with pneumatic lithotriptor under ureteroscopy were treated. The transverse diameter of the stones was 4~12mm and the vertical length 6~15mm. Results 87.7% (93/106) stones were fragmented for one session of treatment. 8 cases were pushed upward then undergoing extracorporeal shock wave lithotripsy(ESWL) after surgical operations. Operations in 5 cases had to be changed to open surgery,and ureteral perforations happened in 1 case. Conclusion Successful entrance of the uretersocop is a prerequisite for crushing the stone,appropriate fixation of the stone is the key to their crushing,spiral stone dislodger is an effective means of fixing ureteral stones.