1.Effect of limestone dusts on health of exposed workers.
Xiao-xin GU ; Chen-yun YANG ; Yong-hong YU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2008;26(8):476-478
Air Pollutants, Occupational
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adverse effects
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analysis
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Calcium Carbonate
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adverse effects
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analysis
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Cross-Sectional Studies
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Dust
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Female
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Humans
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Lung
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drug effects
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physiology
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Male
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Occupational Exposure
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adverse effects
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Pneumoconiosis
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epidemiology
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Sampling Studies
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Surveys and Questionnaires
2.Conceiving of oncologic specianst training
Yazhou HU ; Hong ZHAO ; Yanglin CHEN ; Jin GU
Chinese Journal of Medical Science Research Management 2008;21(5):299-301
According to the design of medical specialist system and the features of Cancer Prevention and Treatment in China, suggestions of Oncologic specialist training were proposed as following. Applying the training by phases is suitable, the conceptions, principles and protocols for Comprehensive treatment and standardized treatment are core contents for the Oncologic specialist training process, which should be carried out in tumor hospital prior to general hospital, the special therapy for the special disease is the aim of Oncolngic specialist training.
3.Giant scalp malignant peripheral nerve sheath tumor: one case report.
Da-wei CHEN ; Wei-hong GU ; Shuang-lin FU
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(12):1047-1048
Head and Neck Neoplasms
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pathology
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Humans
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Male
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Middle Aged
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Neurilemmoma
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pathology
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Neurofibroma
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pathology
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Scalp
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pathology
4.Viral nephropathy.
Gu-ming ZOU ; Yi-pu CHEN ; Hong-rui DONG
Chinese Journal of Pathology 2010;39(2):130-132
Adenovirus Infections, Human
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pathology
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virology
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Glomerulonephritis, Membranous
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pathology
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virology
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HIV Infections
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pathology
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virology
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Hepatitis B
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pathology
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virology
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Hepatitis C
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pathology
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virology
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Herpes Zoster
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pathology
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virology
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Herpesvirus 3, Human
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isolation & purification
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Humans
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Kidney
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pathology
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virology
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Kidney Diseases
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pathology
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virology
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Nephritis, Interstitial
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pathology
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virology
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Parvoviridae Infections
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pathology
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virology
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Parvovirus B19, Human
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isolation & purification
5.Malignant atrophic papulosis: report of a case.
Qian CHEN ; Yong-hong GU ; Zhan-san SU ; Qiong ZOU
Chinese Journal of Pathology 2009;38(12):845-846
Adult
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Female
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Humans
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Intestinal Perforation
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etiology
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pathology
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surgery
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Malignant Atrophic Papulosis
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complications
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pathology
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surgery
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Young Adult
6.The relationship between inhibition of hepatitis B virus replication induced by tumor-necrosis factor α and the up-regulated proprotein convertases
Yan CHEN ; Hong SHI ; Lin GU ; Xiaomou PENG
Chinese Journal of Infectious Diseases 2014;32(2):85-88
Objective To investigate the effects of tumor-necrosis factor α (TNF-α) on the expressions of proprotein convertases (PC) and its relationship with the inhibition of hepatitis B virus (HBV) replication.Methods HepG2.2.15 cells cultured routinely were exposed to 20 μg/L recombinant TNF-α and/or 20 μmol/L PC inhibitor (DEC) for 18 h.Then Followed cells werecollected and cell total RNA and HBV DNA were extracted.PC mRNA and core-associated HBV DNA were measured using real-time polymerase chain reaction (PCR) techniques.Measurement data was compared using t-test.Results When PC mRNA expressions in the blank group was as to 1,the expressions of PC1/3、PC2、furin、PC4 、PC5/6 、PACE4 and PC7/8 mRNA in HepG2.2.15 cells treated with 20μg/L TNF-α treatment for 18 h were all up-regulated,which were 3.3±0.7、79.3±3.3、77.5±1.3、19.2±3.1、1.3±0.1、1.4± 0.2、274.8± 7.1,respectively (all P<0.05).Treatment of 20 μg/L recombinant TNF-α for 18 h significantly reduced core-associated HBV DNA compared with blank gourp (0.21∶1,t =8.79,P =0.002),while 20 μmol/L DEC significantly up-regulated core-associated HBV DNA (3.84∶ 1,t=7.67,P=0.004).Moreover,core-associated HBV DNA in group of DEC and TNF-α treatment was significantly higher than group of TNF-α treatment (0.31∶0.21,t=10.49,P=0.007).Conclusion Up-regulated PC mRNA expression induced by TNF-α is significantly associated with the inhibition of HBV replication.
7.Gene therapy with human vascular endothelial growth factor in prevention of restenosis after angioplasty
Shaoping CHEN ; Hong GU ; Yongchun WANG ; Yongwen QIN ; Guoyuan ZHANG
Academic Journal of Second Military Medical University 2001;22(5):443-446
Objective: To investigate the effect of human vascular endothelial growth factor on restenosis after angioplasty. Methods: A rabbit model of injured carotid artery was established using percutaneous transluminal angioplasty. The pcDNA3/hVEGF165(500 μg,n=12) and pcDNA3 (500 μg,n=12) were separately transfected into injured arterial wall with 30 min incubation. The carotid artery was imaged by arotic angiography at the end of week 2 and week 4. Pathology analysis and Northern blot analysis were performed for harvested injured artery segment. Results: Arotic angiography showed carotid artery diameter narrowness were obviously lessened at week 2 and week 4 in experimental group than that in control group; H-E stains showed lumina narrow ratio were obviously reduced at week 2 and week 4 in experimental group than that in control group[(9.58±1.35)% vs (31.72±1.72)%;(18.09±2.93)% vs (44.05±3.28)%, P<0.01 ]; By Northern blot analysis, the expression of hVEGF165mRNA in experimental group were upregulated than in contol group. Conclusion: pcDNA3/hVEGF165 can be transfected into smooth muscle cell and continue to secret bioactivity protein at least for 4 weeks; it can accelerate reendothelialization and prevent restenosis.
8.Disseminated histoplasmosis in a boy presenting fever and jaundice as first manifestations.
Liang CHENG ; Chun-Yuan CHEN ; Yong-Hong GU
Chinese Journal of Contemporary Pediatrics 2010;12(11):927-928
Child, Preschool
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Fever
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etiology
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Histoplasmosis
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complications
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diagnosis
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pathology
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Humans
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Jaundice
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etiology
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Male
9.Behavioral characteristics of children with tic disorder at different clinic conditions
Chengyao LI ; Hong CHEN ; Jinping JL ; Zhang LIU ; Hongli GU
Clinical Medicine of China 2011;27(12):1334-1337
Objective To assess the behavior of children with tic disorder (TD),and to analyze the behavioral characteristics among children with TD at different clinic conditions.Methods Sixty-three children with TD were evaluated with Child behavior checklist (CBCL).ANOVA and t-test were used to analyze the difference in the total and individual scores of CBCL in the children classified according to the different clinical types,the severity of TD,and comorbid attention-deficit hyperactivity disorder(ADHD).Results There were no significant differences among the total and individual scores of CBCL in the patients of the different clinic types( P < 0.05 ) ;the scores of body complain in the patients in moderate to severe conditions (4.15 ± 2.34) were higher than that of those in mild condition ( 2.68 ± 2.22 ) ( t =- 2.540,P =0.014) ; the scores of attention problem (9.94 ± 3.57 ),disciplinary offence ( 3.94 ± 3.06 ),aggressive behavior ( 15.39 ± 5.12 ),exportoriented behavior problems ( 13.98 ± 7.34)and behavior problem (47.89 ± 17.51 )in TD comorbid ADHD were higher than in simple TD group ( 7.31 ± 3.34,2.44 ± 2.22,7.24 ± 4.93,9.78 ± 6.55,37.07 ± 17.98 ) ( t =- 2.774,- 2.166,- 1.930,- 1.956,- 2.174,P =0.007,0.034,0.048,0.04 1,0.034 ).Conclusion Children with TD at different clinical conditions have varied behavioral problems and behavioral characteristics,while comorbid ADHD is the most significant factor to affect TD patient's behaviors.
10.Three-stage swallowing rehabilitation for stroke patients with dysphagia
Ying GU ; Tieshan LI ; Hong CHEN ; Jinling WANG ; Yongtao LV
Chinese Journal of Physical Medicine and Rehabilitation 2009;31(4):261-263
Objective To explore the effects of three- stage swallowing rehabilitation on the swallowing a-bility of stroke patients with dysphagia. Methods 60 stroke patients were divided into primary cerebral infarction and primary cerebral hemorrhage groups, then further divided into treated and control groups randomly. All groups were given the same routine internal medicine treatment. Patients in the treated group were given three stage swallo-wing rehabilitation training additionally. All patients were assessed using Caiteng's Grading Method at the outset and at the end of the 2nd week, the Ist month and the 2nd month. Results Swallowing function scores in the treated groups were higher than those in the control groups at every stage (P≤0.05). The treated groups' scores also im-proved more quickly than those in the control groups. Conclusion Three stage swallowing rehabilitation can signifi-cantly improve stroke patients' swallowing function.