Objective To reveal the alterations of metabolic profiles by detecting changes in hippocampus1H NMR spectrin acute brain injury (ABI) rats. Methods The model of ABI was achieved by trauma, and 2 hours after modeling, the hippocampus samples were collected for NMR analysis. Results Compared to age-matched control rats, the ABI rats exhibited markedly different metabolic profiles, which showed significant changes in glutamate (P<0.01), taurine(5<0.05), myo-inositol (P< 0.05), and glutamine (P<0.05). Conclusion The metabonomics results suggest that amino acid metabolism is disordered when ABI occurs. This study provides clues for further understanding to cure ABI.

Objective To improve the filtering technique and the addition methods of distillate for Tongtian oral liquid with a new type of filtering equipment. Methods The filter paper in the current filtering process was replaced with a combination of terylene filter cloth and pulvis talci. Distillate was added into the runny paste of preparation directly without using the solubilizer of Tween-80. Then the admixture was agitated sufficiently. After that, 10% NaOH was used to adjust the pH to 4.5-A.5, and the solution was added to 1200 L by water. At last, a clear preparation was obtained by using the above filtering equipment. Results Compared with the product made by the current method, the improved preparation was qualified and tasty. Conclusion The improved method is feasible, simple and economical. The product is tasty.

Objective To compare the results of transcranial Doppler (TCD) in patients with type Ⅱ diabetes and patients with no diabetes to explore the clinical value of TCD in patients with diabetes. Methods The results of TCD were recorded in 60 cases of type Ⅱ diabetes and 60 cases of no diabetes, and then, statistical analysis was performed. Results The patients with type Ⅱ diabetes showed significantly increased peak-systolic velocity, mean velocity and pulsatility indexes of the intracranial blood vessels as compared with the patients with no diabetes (P＜0.05). Conclusion TCD can help to make objective evaluation in patients with cerebrovascular disease and type Ⅱ diabetes,showing its significance in preventing the cerebrovascular disease in patients with diabetes.