1.Clinical Application of Total Extraperitoneal Inguinal Hernia Repair Under Two Laparoscopes
Chinese Journal of Minimally Invasive Surgery 2017;17(6):524-526
Objective To study the feasibility and the efficacy of total extraperitoneal repair (TEP) under two laparoscopes.Methods Clinical data of 51 patients with inguinal hernia who underwent TEP under two laparoscopes from July 2015 to March 2016 in our hospital were analyzed retrospectively.During TEP,we added a 5-mm laparoscope for monitoring and exploration in the abdominal cavity.Results All the operations of TEP under two laparoscopes were successful.The operation time lasted 42-176 min with a mean of (74 ±27) min.The intraoperative blood loss was 5-30 ml with a mean of (12.8 ±5.9) ml.The length of postoperative hospital stay was 2-7 days with a mean of (4.0 ± 1.1) days.The percentage of postoperative complications was 11.8% (6/51),including inguinal area seroma which accounted for 2.0% (1/51),inguinal region pain accounting for 3.9% (2/51),and postoperative urinary retention for 5.9% (3/51).No infection was found.The follow-up period ranged from 3 to 11 months (mean,7 months),no recurrence was observed during this period.Conclusions TEP under two laparoscopes can treat inguinal hernia precisely.It is also helpful to find compound inguinal hernia and occult inguinal hernia.
2.The application of PBL in evidence-based medicine teaching among international students
Qin LIU ; Hong WANG ; Zhaohui ZHONG
Chinese Journal of Medical Education Research 2011;10(9):1133-1135
PBL ( Problem-based learning) is a problem-based and student-centered learning pattern.PBL teaching method has been applied to evidence-based medicine ( EBM ) courses for international students.By this method,the students' learning enthusiasm was stimulated,the ability of ananlyzing and resolving problem was improved,and good teaching effect was achieved,which provided knowledge to improve further EBM teaching and evidence-based clinical practice.
3.Clinicopathological analysis of solid-pseudopapillary tumor of the pancreas
Zhongwen ZHONG ; Peirong SUN ; Hong WANG
China Oncology 2001;0(03):-
Purpose:To study clinical and pathological features of solid-pseudopapillary tumor(SPT) of the pancreas. Methods:The clinical data were reviewed in four patients with SPT. Immunohistochemistry for Vim, CK8, CK18, Chromogranin, Sy, AAT, NSE, S-100 was performed in all four cases using EnVision. Results:All four patients were female. The mean age was 30 years. The tumors were composed of papillary and solid structures. The uniform cells were strongly diffuse positive for Vim, and strongly positive for focal AAT in four cases. Three cases were positive for NSE. All four cases were negative for Sy , Chromogranin and S-100. One case was poorly positive for CK8 and CK18. Conclusions:SPT of the pancreas, preferentially in young women, is a tumor with low malignant potential. Immunohistochemistry is very important in the diagnosis and differential diagnosis of SPT of the pancreas..
4.Advance in Treatment of Spinal Cord Injuries with Schwann Cells Transplantion(review)
Lei XIA ; Hong WAN ; Zhong-cheng WANG
Chinese Journal of Rehabilitation Theory and Practice 2006;12(7):553-555
Schwann cells (SCs) have potently neuroprotective and myelinization abilities. They are one of the earliest and the most frequently used cells that are applied to therapeutic studies in spinal cord injury. At present, SCs are usually used as a platform for therapeutic alliance to integrate various interventions. This review will mainly discuss the issues met in therapeutic alliances with SCs for spinal cord injuries, results of various therapeutic alliances with SCs, positive effects of co-transplantation with SCs on neural stem cells, survival, migration of SCs after transplantation and roles of endogenetic SCs in repairing spinal cord injury.
5.Alagille syndrome in 5 Chinese children.
Jian-She WANG ; Xiao-Hong WANG ; Zhong-Lin WANG
Chinese Journal of Pediatrics 2007;45(4):308-309
Alagille Syndrome
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pathology
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Child, Preschool
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China
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Female
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Humans
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Infant
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Male
6.Clinical observation and follow-up study on acute promyelocytic leukemia in childhood treated mainly with arsenic trioxide.
Liang-chun HAO ; Hong WANG ; Li-zhong ZHANG
Chinese Journal of Pediatrics 2005;43(7):534-535
Antineoplastic Agents
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therapeutic use
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Arsenicals
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therapeutic use
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Child
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Child, Preschool
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Disease-Free Survival
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Female
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Follow-Up Studies
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Humans
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Leukemia, Promyelocytic, Acute
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drug therapy
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Male
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Oxides
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therapeutic use
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Remission Induction
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methods
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Survival Rate
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Treatment Outcome
7.Implementation of performance metrics in clinical trial data management.
Ya-zhong DENG ; Hong-wei WANG ; Hai-jun FU
Acta Pharmaceutica Sinica 2015;50(11):1488-1492
There is no a systemic performance metrics for clinical data management. While the CDMC in China starts to develop the quality metrics for clinical data management, it is essential to think over the performance and pursue metrics implementation of clinical data management in China. This article provides the basic concept, development and implementation of the performance metric in clinical data management.
China
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Clinical Trials as Topic
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standards
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Data Collection
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standards
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Information Storage and Retrieval
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standards
8.Process and method for CDISC-based CRF annotation.
Hong-wei WANG ; Ya-zhong DENG ; Daniel LIU
Acta Pharmaceutica Sinica 2015;50(11):1474-1479
A CDASH-based CRF annotation plays an important role in database setup and data verification. The STDM-based CRF annotation is also one of the essential documents when the package of clinical trial data is submitted to the regulatory authority. This paper describes the contents, procedures and related stipulations used in the CDISC-based CRF annotation.
Clinical Trials as Topic
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Databases, Factual
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Documentation
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standards
9.Accumulation of p53 and cytokeratin-18neo in non-small cell lung cancer and its clinicopathological significance
Yongyi LIU ; Xueyun ZHONG ; Yunxian CHEN ; Hong SHEN ; Zineng WANG
Chinese Journal of Pathophysiology 2001;17(6):538-541
AIM: To investigate the tumorigenicity of lung cancer by learning the accumulation of p53 and the exposure of cytokeratin 18 neo-epitope(CK-18neo) related to the clinicopathological parameters in non-small cell lung cancer(NSCLC). METHODS: To detect the monoclonal antibodies of p53 and M30 CytoDEATH(specific antibody for CK-18neo) in 62 cases of NSCLC (included 29 cases of squamous cell carcinoma and 33 cases of adenocarcinoma) and 10 cases of control group by adopting immunohistochemistry assay (LSAB). Moreover, the immunoreactivity of p53 was quantitatively evaluated with positive unit (PU). RESULTS: (1) p53 immunoreactivity was positive in 15 of 29 squamous cell carcinoma (51.72%), 15 of 33 adenocarcinoma (45.45%), 30 of 62 NSCLC (48.39%). In 10 control cases was negative. There were significant differences between these groups (P<0.01). (2)In 62 cases of NSCLC, AI% of M30 is 1.10%, and in 29 cases of squamous cell carcinoma is 0.95%, and in 33 cases of adenocarcinoma is 1.24%. In 10 control cases, the AI% is 1.06%. There is not significant difference among these groups . (3) According to the results of Pearson's correlation analysis, we found positive linear correlation between the immunoreactivity of p53(-/+), p53(5 degrees)and p53(PU)(P<0.01). CONCLUSION: Our results suggested that the pathogenesis of NSCLC might be related to the mutation of gene p53 and cell excessive proliferation and insufficient apoptosis.
10.Reforms for the curriculum system of preventive medicine
Hong WANG ; Jingfu QIU ; Junlin HE ; Peng HUANG ; Xiaoni ZHONG
Chinese Journal of Medical Education Research 2011;10(2):227-230
Against the deficiencies of the current preventive medicine education curriculum,training programs and curriculum were reformed according to the training objectives of the modem preventive medicine, while new ideas of preventive medical personnel training were explored in order to cultivate practical professionals with a certain ability to innovate and to adapt the development of modern public health and preventive medicine preferably.