Objective To explore the relationship of preoperative hemoglobin concentration and use of hospital resources.Methods 108 patients receiving cardiac surgery in the central hospital of wuhan were included.The relationship of preoperative hemoglobin concentration was explored on blood transfusion rates,return to the operating room for bleeding and/or cardiac tamponade,postoperative intensive care unit(ICU)and in-hospital length of stay,and mortality.Results For every 10-unit increase in hemoglobin(g/L),blood transfusion requirements were reduced by 8.0%,6.0%,and 3.0% for red blood cell units,platelet pools,and fresh frozen plasma units,respectively.For each 10-unit decrease in hemoglobin(g/L),the probability(over time)of discharge from the ICU and hospital increased 7.0%,16.0% respectively.Conclusion A lower preoperative hemoglobin concentration resulted in increased use of hospital resources after cardiac surgery.Therefore,the correction of decreasing preoperative hemoglobin concentration could improve the use of hospital resources after cardiac surgery.

Objective To analyze the incidence,risk factors,and impact of intraoperative conversion on the mortality in patients undergoing off-pump coronary artery bypass grafting.Methods This retrospective observational study included 207 patients undergoing off-pump coronary artery bypass grafting.According to whether intraoperative conversion,207 patients were randomly divided into intraoperative unchanged group(191 cases)and intraoperative changed group(16 cases).The incidence,patient characteristics,cause of intraoperative conversion,and its impact on outcome were studied.Results Intraoperative conversion increases odds for mortality to 25.0%,while the other group was 1.0%.The most common cause for intraoperative conversion was hemodynamic disturbances during grafting to the obtuse marginal artery.On multivariate logistic regression analysis,left main disease,mitral regurgitation and higher EuroSCORE II independently predicted intraoperative conversion.Conclusion Intraoperative conversion to on-pump coronary artery bypass grafting is independently associated with higher mortality in patients undergoing off-pump coronary artery bypass grafting.Identification of high risk group of intraoperative conversion may improve the outcome.

Objective To study and analyze the curative effect of linezolid in the treatment of severe pneumonia and the psychological countermeasures. Methods 100 cases of severe pneumonia patients treated in our hospital from March 2015 to August 2016 were selected and randomly divided into the control group and the experimental group. Two groups of patients according to the actual situation of patients with nutritional support and supplement electrolyte based treatment. The control group was treated with levofloxacin and ceftriaxone infusion treatment, the experimental group underwent intravenous linezolid therapy, and psychological care, pay attention to the psychological status of patients and patients, strengthen communication and exchanges, increase confidence in the treatment and the treatment compliance of patients. The therapeutic effects of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the number of invalid cases in the experimental group was 4 cases, the number of effective cases was 31 cases, and the number of effective cases was 15 cases. The number of invalid cases in the control group was 10 cases, the effective number was 26 cases, and the effective cases were 14 cases. The effective rate of treatment in the experimental group was 92.0％, which was significantly higher than that in the control group, and the effective rate was 80.0％, with statistical difference (P<0.05). There were no obvious adverse reactions in the experimental group and the control group. The rate of adverse reactions in the control group was 14.0％, significantly higher than that in the experimental group (2.0％), and there was a statistical difference (P<0.05). Conclusion Linezolid is effective in the treatment of severe pneumonia, it can improve the therapeutic effect to a certain extent, and it has high security, it has the significance of clinical promotion.

Brain ; physiology ; Humans ; Magnetic Resonance Imaging ; Mastication ; physiology

Humans ; Lung Neoplasms ; blood supply ; pathology ; Lymphatic Vessels ; pathology ; Neovascularization, Pathologic ; metabolism ; Vascular Endothelial Growth Factors ; chemistry ; metabolism ; physiology

Humans ; Nerve Growth Factor ; physiology ; Pain ; physiopathology ; Pulpitis ; physiopathology ; Receptor, Nerve Growth Factor ; physiology ; Receptor, trkA ; physiology

A variety of extra-cellular signals could activate the target molecules and induce the associated biological effects depended on different signal pathways. Apoptosis, or programmed cell death, is a conservation process essential for normal development and homeostasis of biologist. It's known that a number of factors and pathways can lead to apoptosis. Specific phosphorlipids and proteins of biomembrane could activate the signal cascades of apoptosis. The interaction of caspases, bcl-2 family and mitochondria play an essential role in regulation of apoptosis.

Objective To investigate the optimum scanning parameters for multi-slice spiral CT aorta imaging so as to emphasize the contrast delay time and the method of image reconstruction.Methods 21 cases of patients were scanned with contrast enhancement by the method of bolus tracking.The contrast medicine was injected through elbow vein.Flow speed was 3.0ml/s,and contrast usage was 1.5 to 2ml/ kg.Scanning was triggered when the density of the enhancement at ROI arose to a prescribed value.After data acquisition and reconstruction,the aorta was displayed.Results The average time for the influx of contrast in aorta was 20 seconds.Data was reformatted with the thickness of 2.5mm and 50% overlapping.VR,CPR,MIP and SSD images were reconstructed.Conclusion With constant tracking of density by Smartprep software,the optimized scanning parameters and the proper image post-processing techniques,aorta can be clearly displayed.[Chinese Medical Equipment Journal,2008,29(2):88-89]

Objective To investigate the dose-response and its mechanisms of preventive effect of 103 Pd radioactive stent on restenosis in rabbits after balloon injury. Methods The abdominal arteries of the rabbits randomized into common or radioactive stent groups (including 5 Gy, 15 Gy, 25 Gy, 35 Gy groups) were balloon injured, and then stented. Intravascular ultrasound and angiography on abdominal arteries, immunohistochemical study of PCNA, and TUNEL assay were performed 8 weeks after stenting. Results Both the minimal lumen diameters and in-stent lumen areas in 103 Pd radioactive stent groups [(1.94?0.21) mm and (5.99?0.43) mm2, (2.17?0.12) mm and (7.01?0.93) mm2, (2.43?0.22) mm and (8.09?0.89) mm2, (2.56?0.27) mm and (8.49?0.54) mm2 in turn in 5 Gy, 15 Gy, 25 Gy, 35 Gy groups, respectively]were significantly improved with increases of the doses at the end of 8 weeks,revealing a dose-response effect. The positive ratio of PCNA in each 103 Pd stent group was reduced as compared with that in commen stent group (P

Objective:To determine whether there were alteration of miRNA expression in peripheral Treg cells,through the contrast between normal people and patients with ITP and to explore the pathogenesis of ITP.Methods:Peripheral blood was obtained from ITP patients and normal people ,and Treg cells were isolated by flow cytometry.RNA was extracted from Tregs in each group,then for miRNA arrays analysis through Solexa sequencing.Compare ITP group and normal control group microarray to identify differentially expressed miRNA.Differentially expressed miRNA were analyzed to find the abnormal signaling pathways.Results: We screened multiple miRNA abnormal expression in Treg cell of ITP patients,which has significant differences were miR-1976,miR-548ae-5p,miR-5096-p3,miR-548am-5p,PC-3p-63471,and PC-3p-96627.By enrichment analysis,we found two abnormal signaling pathways:ErbB signaling pathway and TGF-βsignaling pathway.Conclusion:Differentially expressed miRNA were found in peripheral Treg cell of ITP patients,which may be affected the normal functioning immune regulation of Treg cells,and involved in the pathogenesis of ITP.