ObjectiveTo study the necessity of treating prolapse of lumbar intervertebral disc by active movement treatment. Methods68 patients with prolapse of lumbar intervertebral disc were divided into the group of active movement treatment (31 cases) and the control group (37 cases). One year later, the recurrence rate and F wave motor nerve conduction velocity of two groups were compared. ResultsThere is a lower recurrence rate (P<0.05) and a faster F wave motor nerve conduction velocity (P<0.01) in the group of active movement treatment compared with the control group. F wave motor nerve conduction velocity of the group of active movement treatment is also faster than that of 1 year ago (P<0.001). Conclusions It is necessary for patients with prolapse of lumbar intervertebral disc doing active movement.

Animals ; Drugs, Chinese Herbal ; pharmacology ; Hematopoietic System ; drug effects ; Male ; Physical Conditioning, Animal ; Rats ; Rats, Wistar

Animals ; Drugs, Chinese Herbal ; pharmacology ; Male ; Myocytes, Cardiac ; drug effects ; enzymology ; Physical Conditioning, Animal ; Rats ; Rats, Wistar

In the present study, a new compound named 17-(6-cinnamamido-hexylamino-)-17-demethoxygeldanamycin (CDG) was obtained by introducing the cinnamic acid (CA) group into the 17-site of geldanamycin (GDM). The anti-cancer effects of CDG in vitro and in vivo were evaluated. MTT assay was used to examine the inhibitory effect of CDG on the proliferation of MCF-7, HepG2, H460 and SW1990 cells. Immunofluorescent staining flow cytometry combined with Annexin V-FITC/PI staining were used to detect apoptotic cells. Transwell assay was used to analyze the effect of CDG on cell invasion and migration ability. Western blotting was used to detect the expression levels of RAF-1, EGFR, AKT, CDK4 and HER-2 of MCF-7, HepG2 and H460 cells. The toxicities of CDG and GDM were evaluated in mice. Using the subcutaneously transplanted MCF-7 xenograft in nude mice, inhibitory effect was evaluated in vivo. The results showed that CDG inhibited the proliferation of cancer cells (IC50: 13.6-67.4 microg.mL-1). After exposure to CDG for 48 h, most cells presented typical morphologic changes of apoptosis such as chromatin condensation or shrunken nucleus. The rates of apoptosis of MCF-7, HepG2, H460 and SW1990 cells incubated with 10 microg.mL-1 CDG were 23.16%, 27.55%, 22.21%, 20.47%, respectively. A dose-dependent reduction of migration of four cell lines was found after exposure to CDG. The decreased levels of RAF-1, EGFR, AKT, CDK4 and HER-2 showed that CDG possessed HSP90 inhibitory effect. The result of animal toxicity test on the mice suggested that CDG had lower toxicity than GDM. Meanwhile, CDG inhibited the growth of MCF-7 xenografts of athymic mice.

OBJECTIVETo observe the clinical efficacy of Qi-supplementing and blood-activating (QSBA) in treating diabetic peripheral nephropathy (DPN).

METHODSSixty-eight type 2 diabetes mellitus patients with Qi deficiency-blood stasis Syndrome were randomly divided into two groups, the neurotrophic agents were used in both groups, while QSBA herbs were used in the treated group additionally. The treatment course was 2 months. Blood glucose (BG), triglyceride (TG), total cholesterol (TC) and nerve conduction velocity (NCV) were detected before and after treatment.

RESULTSAfter treatment, the BG, blood lipid, NCV were improved significantly (P < 0.05) in both groups, but the improvement was more significant in the QSBA treated group than in the control group (P < 0.05).

CONCLUSIONQSBA, in treating DPN, can not only improve its symptoms, but also ameliorate the NCV.

Adult ; Aged ; Diabetic Neuropathies ; drug therapy ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Neural Conduction ; drug effects ; Phytotherapy ; Qi

OBJECTIVETo provide objective data for position and orientation of zygomatic-area implant used in zygo-buccal flange osseointegrated implant obturator for patients with large maxillary defect.

METHODSFifty cases of normal unilateral zygomatic body with dentition were measured on three-dimensional spiral CT images. Measurements included the slope angle of zygomatic body on sagittal sectional image, the maximal horizontal distance from the buccal boundary of maxillary alveolar to outboard of maxillary sinus. Furthermore, the configuration of zygomatic body was observed on coronal sectional image.

RESULTSThe average rearward slope angle of zygomatic-body was 80.03 degrees. Forty-eight cases showed straight zygomatic-body configurations and two cases quite curvy. The maximal horizontal distance from the buccal boundary of maxillary alveolar to outboard of maxillary sinus was 6.77 mm.

CONCLUSIONSIn a normal condition, implants can be upright inserted tilting about 10 degrees ahead to utilize much zygomatic bone-volume in high site. In order to improve security and validity of implantation, it is better to take spiral CT examination to evaluate the bone volume and shape of zygomatic body before zygomatic-area implant.

Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Maxillofacial Prosthesis Implantation ; methods ; Middle Aged ; Tomography, Spiral Computed ; Young Adult ; Zygoma ; diagnostic imaging ; surgery

Adult ; Humans ; Lipomatosis, Multiple Symmetrical ; Male ; Middle Aged

Objective To compare the scores of amplitude-integrated electroencephalogram (aEEG) tracings between preterm infants who were smaller for gestational age (SGA) and those who were appropriate for gestation (AGA).Methods A total of 139 preterm infants were collected in the Neonatal Intensive Care Unit of the Affiliated Hospital of Guangdong Medical College during the period of Mar.2013 to Feb.2014.One hundred and fourteen patients met the inclusion criteria with gestational ages from 32 to 36 weeks at birth,including 54 SGA infants and 60 AGA infants.The aEEG recordings were obtained within 72 h after birth by using the NicoletOne monitor.Duration of each recording was at least 3 h.Five aspects of each tracing,such as continuity (Co),sleep-wake cycling (Cy),amplitude of the lower border (LB),bandwidth (B) and total maturation scores,were evaluated and compared between 2 groups by applying a aEEG scoring system.Results 1.As SGA infants,scores for Co,Cy,LB,B as well as total maturation scores were progressively increased with gestational age advancing(all P ＜ 0.05).As AGA infants,scores for Cy,B and total maturation scores progressively increased with advancing gestational age (all P ＜ 0.05),but there were no statistical differences between each gestational ages in Co,LB scores (all P ＞ 0.05).2.Linear regression analysis of SGA infants' gestational age to Co,Cy,LB,B and total maturation scores showed positively correlation,and the correlation coefficients were 0.438,0.597,0.385,0.606 and 0.608,respectively (all P ＜ 0.05).As AGA infants,a positive correlation between gestational age and Cy,B as well as total maturation scores were observed,and the correlation coefficients were 0.528,0.615 and 0.635,respectively (all P ＜ 0.05).3.At the same gestational age,both the B scores and total maturation scores in SGA group were lower than those in AGA group.Conclusions SGA and AGA,Co,Cy and total maturation scores can be used to evaluate the maturation of cerebral function.At the same gestational age,the scores of B and total maturation scores are lower in the SGA,and this might be associated with their delayed neuromotor development.

Canavan Disease ; chemically induced ; complications ; Hearing Loss, Sudden ; etiology ; Heroin ; poisoning ; Humans ; Male ; Middle Aged

Diagnosis, Differential ; Endometrial Stromal Tumors ; metabolism ; pathology ; surgery ; Female ; Follow-Up Studies ; Gastrointestinal Stromal Tumors ; pathology ; Humans ; Leiomyoma ; metabolism ; pathology ; Middle Aged ; Neprilysin ; metabolism ; Receptors, Estrogen ; metabolism ; Receptors, Progesterone ; metabolism ; Rectal Neoplasms ; metabolism ; pathology ; surgery ; Rectum ; surgery ; Solitary Fibrous Tumors ; metabolism ; pathology