1.Recent advances in adenoid cystic carcinoma of minor salivary gland.
Chinese Journal of Pathology 2011;40(11):783-787
Adenocarcinoma
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pathology
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Adenoma
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pathology
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Carcinoma, Adenoid Cystic
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epidemiology
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genetics
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metabolism
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pathology
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Carcinoma, Basosquamous
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pathology
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DNA, Mitochondrial
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genetics
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Diagnosis, Differential
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Humans
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Immunohistochemistry
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Incidence
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Proto-Oncogene Proteins c-kit
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metabolism
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Salivary Gland Neoplasms
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epidemiology
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genetics
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metabolism
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pathology
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Salivary Glands, Minor
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pathology
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beta-Defensins
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genetics
2.Cost-effectiveness Analysis of Three Angiotension-converting Enzyme Inhibitors in Treatment of Essential Hypertension
Gang LI ; Hong ZHOU ; Shiming SUN
China Pharmacy 2001;0(10):-
OBJECTIVE:To evaluate the economic effectiveness of three angiotension-converting enzyme inhibitor(ACEI) in treating patients with essential hypertension.METHODS:186 patients with essential hypertension were randomly divided into three groups receiving enalapril,fosinopril and perindopril respectively.The results were evaluated with pharmacoeconomic analysis.RESULTS:In treatment of hypertension,enalapril was minimal in cost.CONCLUSION:Therapeutic effect will be improved and cost decreased when pharmacoeconomic cost-effectiveness analysis is used.
3.Clinical study of bortezomib in the treatment of multiple myeloma patients with renal failure.
Zhi-gang CAO ; Mo LIU ; Hong-wei ZHOU
Chinese Journal of Hematology 2013;34(1):74-75
Adult
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Aged
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Boronic Acids
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therapeutic use
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Bortezomib
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Female
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Humans
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Male
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Middle Aged
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Multiple Myeloma
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complications
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drug therapy
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Pyrazines
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therapeutic use
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Renal Insufficiency
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complications
;
drug therapy
4.L1-L2 complete traumatic fracture-dislocation of the lumbar spine: a case report.
Gang-xiang WANG ; Zhi-gang WANG ; Hai-dong ZHOU ; Hong-yu XU
China Journal of Orthopaedics and Traumatology 2015;28(9):868-869
Adult
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Humans
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Joint Dislocations
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surgery
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Lumbar Vertebrae
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injuries
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surgery
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Male
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Spinal Fractures
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surgery
5.High-grade transformation in adenoid cystic carcinoma: a clinicopathologic study.
Quan ZHOU ; Hong CHANG ; Yi-ding HAN ; Ying GAO ; Hong-gang LIU
Chinese Journal of Pathology 2013;42(2):106-110
OBJECTIVETo study the clinicopathologic features and possible molecular mechanisms of adenoid cystic carcinoma with high-grade transformation.
METHODSFour cases of adenoid cystic carcinoma with high-grade transformation were enrolled into the study. Immunohistochemical study for smooth muscle actin, p63, p53 and Ki-67 was carried out. C-myc gene status was analyzed by fluorescence in-situ hybridization.
RESULTSThere were altogether 3 males and 1 female. The mean age of the patients was 55.5 years. Two patients died 17 months and 29 months after operation, respectively. One patient had distant metastasis 23 months after operation and was still alive at 26-month follow up. The remaining patient remained tumor free at 3-month follow up. High-grade transformation in adenoid cystic carcinoma presented either as poorly differentiated adenocarcinoma or undifferentiated carcinoma. Histologic examination showed sheets of pleomorphic tumor cells occupying more than one low-power field. The high-grade carcinoma cells showed increased nuclear-cytoplasmic ratio, prominent eosinophilic nucleoli and active mitosis (ranging from 8 to 25 per high-power field). Comedo necrosis was observed in 2 cases and multiple foci of calcifications in 3 cases. Immunohistochemical study demonstrated loss of myoepithelial differentiation, overexpression of p53 and high proliferative index by Ki-67. No c-myc translocation or copy-number changes were observed.
CONCLUSIONSHigh-grade transformation in adenoid cystic carcinoma is rare. The histopathologic features are rather distinctive and the biologic behavior is aggressive. C-myc gene mutation does not seem to play a key role in the pathogenesis.
Actins ; metabolism ; Adenocarcinoma ; genetics ; metabolism ; pathology ; Adult ; Aged ; Carcinoma ; genetics ; metabolism ; pathology ; Carcinoma, Adenoid Cystic ; genetics ; metabolism ; pathology ; Cell Transformation, Neoplastic ; Eye Neoplasms ; genetics ; metabolism ; pathology ; Female ; Follow-Up Studies ; Genes, myc ; Humans ; Ki-67 Antigen ; metabolism ; Lacrimal Apparatus ; Lacrimal Apparatus Diseases ; genetics ; metabolism ; pathology ; Lung Neoplasms ; genetics ; metabolism ; pathology ; Male ; Maxillary Sinus Neoplasms ; genetics ; metabolism ; pathology ; Membrane Proteins ; metabolism ; Middle Aged ; Mutation ; Parotid Neoplasms ; genetics ; metabolism ; pathology ; Survival Rate ; Tumor Suppressor Protein p53 ; metabolism
6."Myositis-like" T-cell lymphoma: report of a case.
Xiao-ge ZHOU ; Yan SHI ; Gang CHEN ; Yuan-yuan ZHENG ; Yan-ning ZHANG ; Shu-hong ZHANG
Chinese Journal of Pathology 2008;37(6):422-423
7.Expressions of granulocyte-macrophage colony-stimulating factor and myeloperoxidase in bronchoalveolar lavage fluid in children with Mycoplasma pneumoniae pneumonia and its clinical significance
Hong ZHOU ; Qinglei XU ; Xiaobo MA ; Peiqi XU ; Gang LIU ; Min ZHANG ; Yue JIN ; Zhengrong CHEN
Chinese Journal of Applied Clinical Pediatrics 2017;32(4):313-315
8.Research Progress on Rcombinant Hepatitis B e Antigen
Qian ZHOU ; Xiao-Wei HE ; Zhi-Gang LUO ; Xi-Hong ZHAO ;
China Biotechnology 2006;0(06):-
HBeAg is an ungranular secretory protein,which encoded by C gene of HBV DNA and it increases with the replication of HBV. So it is one of the markers of active replication of HBV in clinical diagnosis. HBeAg is important biologic raw materials which is widely used in preparation of related diagnostic articles with HBV infection serological detection. The technology of expression and purification of recombinant HBeAg is quite mature,which had successfully expressed the target protein in various expression systems. The key factors on HBeAg expression include important site mutation in precore region ,the choice of vectors,effects of RNA interference(RNAi)and so on. Therefore,in order to meet requirements of related diagnostic products,it need to improve expression level and purity of recombinant HBeAg and avoid cross-reaction with HBcAg. In a word,it showed that acquisition of high quality recombinant HBeAg could lay substantial foundation for improving diagnostic products,provide a reliable evidence for exploiting new type of therapeutic and preventive HBV vaccine and offer possibility of HBeAb detection methodological optimization.
9.High-frequency electrocautery in the treatment of massive hemorrhage of presacral venous plexus
Meng LUO ; Yongwei SUN ; Qing XU ; Wei CHEN ; Gang ZHAO ; Hong ZHOU ; Bin ZHANG ; Zhiyong WU
Chinese Journal of Digestive Surgery 2008;7(5):354-355
Objective To assess the clinical value of high-frequency electrocautery in the treatment of massive hemorrhage of presacral venous plexus. Methods The clinical data of 8 patients with presacral venous hemorrhage treated with high-frequency electrocautery from February 2005 to March 2008 were analyzed. Once the presacral venous hemorrhage happened, the bleeding site was pressed with a gauze or finger and the accumulated blood was aspirated. Then, while simultaneously withdrawing the gauze or finger over the bleeding sites, high-frequency electrocautery was applied with a power of 80-100 W to coagulate all the bleeding sites. Results High-frequency electrocautery was used to stop bleeding in the 8 patients, and no electrocautery related complica-tions occurred postoperatively. Conclusions High-frequency electrocautery for massive hemorrhage of presacral venous plexus is simple, efficient and safe.
10.Interventional regional arterial infusion treatment for severe acute pancreatitis
Zaiping ZHOU ; Zemin HU ; Yuanlong YU ; Gang XIE ; Hong CHEN ; Xiaoqun LI
Chinese Journal of Postgraduates of Medicine 2006;0(02):-
Objective To evaluate the potential of interventional regional arterial infusion for severe acute pancreatitis (SAP). Methods Regional arterial infusion with somatostatin and antibiotic was performed in 20 cases of SAP within 4 hours after diagnosis confirmed,and pressurized infusion lasted for 5 days. Another 28 cases of SAP as control group received drug treatment all over the body. The SAP clinical data such as symptom,mortality,complication rate and stay time in hospital were analysed in two groups. Results There were significant differences in remission,serum amylase,urine amylase and lipase between the regional and total infusion groups. The stay time in hospital,mortality,complication and operation rate were lower in regional infusion group than those of control group(P