The coronary collateral circulation is an alternative source of blood supply to the myocardium jeopardized by failure of the original vessel to provide adequate flow. Angiogenesis growth factors induce angiogenesis to promote collateral circulation, been demonstrated in a number of different animal test and phase Ⅰ clinical experience to induce collateralization in the ischemic area and improve cardiac function. Although there are several unsolved questions, the pharmacologic use of angiogenesis growth factors will represent a viable therapeutic alternative for the patients with ischemic heart disease.

By generalizing the integrity crisis of college students,the article analyzes the causes of this phenomenon,and proposes a series of measures aiming at strengthening integrity education,establishing the favorable environment,completing the mechanism of rewards and punishments and building the credit system,in the hope of securing the deepening and full completion of good-faith education at college,both ideologically and systematically.

OBJECTIVE:To research the correlation between per capita disposable income,investment of pharmaceutical advertisement,people’s healthy level,pharmaceutical price and the demand of drugs in China METHODS:Based on the economical theory,the methods of the econometrics and the Eviews were adopted to establish the model of demand function RESULTS & CONCLUSION:Under the background of the non-full competition,the improvement of people’s living conditions can lead to the demand of drugs The changes of drug price have little influence on the demand of drugs

Aged ; Calcinosis ; complications ; Heart Aneurysm ; complications ; Heart Ventricles ; Humans ; Male ; Thrombosis ; complications

Objective To study on the correlation of hepatic fibrosis with angiotensin Ⅱ (Ang Ⅱ ) in the hepatitis B patients . Methods The electrochemical luminescence and the rate method were adopted to detect hyaluronidase (HA) and Ang Ⅱ levels in 92 cases of acute hepatitis B (acute group) ,108 cases of chronic hepatitis B(chronic group) and 50 healthy people(control group) , and the detected results were performed the correlation analysis .Results Compared with the acute group and the control group ,the HA and Ang Ⅱ levels in the chronic group were increased significantly (P<0 .05) .The HA and Ang Ⅱ levels had statistical differ-ence between the acute group and the control group (P<0 .05) .Further analysis showed that there was a positive correlation be-tween HA and Ang Ⅱ levels(r=0 .629 ,P<0 .05) .Conclusion There the HA level is closely related with the Ang Ⅱ level ,and both of them participate in the process of liver fibrosis ,their levels have the guiding significance in evaluation of severity of liver fi-brosis in the patients with hepatitis B .

Objective To find the inpact(s) of Losartan on myocardial apoptosis in rats with heart failure. Methods Eight-week-old male SD rats were divided into control group (group C) , heart failure (group HF) and treatment group (group LS). Use of doxorubicin injection model, group LS at the same time in a row to the oral losartan, myocardial ultrastructure was examined by TEM. DNA-situ terminal labeling (TUNEL method) was used to detect myocardial apoptosis and myocardial BAX, BCL-2 protein expression was detected by immunohistochemistry. Results Group HF showed significant myocardial cell injury, and apoptotic bodies were found, serum CPK, CK-MB and LDH were increased. In LS group, myocardial apoptosis index was lower (P <0. 01) , myocardial cells BCL-2 expression, BAX expression reduced as compared with those in HF group. Conclusion Losartan can effectively inhibit the process of heart failure occurred in cardiomyocyte apoptosis, reverse myocardial damage and improve the prognosis of heart failure.

Lysyal oxidase (LOX),a cooper dependent monoamine oxidase,can stabilize the extracellular matrix and is closely related to the tumor cell differentiation,vicious transformation and invasiveness.LOX is secreted into extracellular,and it is resolved into a small fragment by sol protease,which is lysyal oxidase propeptide (LOX-PP).According to research,LOX-PP has its own structure and physiological functions,which can inhibit the growth of tumor cells.LOX-PP also plays a significant role in the generation and progression of tumor,which is likely to be a new therapeutic target.

Dorsal-ventral axis formation is one of the earliest and the most important steps of patterning formation during early embryogenesis.The molecular basis of dorsoventral axis formation reflects the fundamental issues of orchestrated cell proliferation and differentiation.Wildly speculated since the Renaissance,the effort of deciphering the mechanisms of dorsal-ventral axis formation has contributed significantly to our current understanding of disease pathogenesis.Here,we focused our discussion on the recent discovery of the convergence of dorsal and ventral signaling pathways during early embryogenesis and its implications in cancer biology and beyond.

AIM: To establish the quality standard of Huoxuejiangu Capsules (Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Astragali seu Hedysari, Rhizoma Corydalis, Fructus Psoraleae, etc.). METHODS: Radix Astragali, Rhizoma Corydalis, Radix Paeoniae Rubra, Fructus Psoraleae were identified by TLC. The content of tanshinone Ⅱ A was determined by HPLC. RESULTS: Radix Astragali, Rhizoma Corydalis, Radix Paeoniae Rubra, Fructus Psoraleae could be dtected by TLC. Tanshinone Ⅱ A showed a good linear relationship at the range of 0.106～2.12?g, r =0.9996. The average recovery was 98.6%, and RSD was 1.48%. CONCLUSION: The method established is simple, feasible and reproducible. This study provided a method for quality control of Huoxuejiangu Capsules.

Animal experiment is one of the most important method in life science research. In this article,factors affecting the results of animal experiment were summarized,which include laboratory animal,environment,nutrition,chemicals,isolation and feeding density,transportation,grasping and fixing,microbiology,society and people etc.