Taking Liaoning Medical University as an example , the paper introduces the Problem -based learning ( PBL) teaching mode into the teaching of the medical information retrieval course for graduate students .It introduces the overall design and arrangement of PBL teaching and the implementation process of teaching .By questionnaire surveys , analysis of individual retrieval reports and assess-ment of PBL teaching effects , it points out existing problems and proposes several measures for optimizing PBL teaching .

Objective To develop a method for nou-invasive risk model that can be used in health management system and primary healthcare centers. Methods Based on systematic phenotype measurement and modified superviser-based machine learning, an applicable and low-cost method for non-invasive disease risk prediction model was developed. Invasive risk assessment model for Chinese isehemic cardiovascular diseases (ICVD) was used as a supervised standard reference to provide evidence based non-invasive model with skin resistance on 24 acupeints. Results A total of 4606 cases from a physical examination system were collected to develop the model. For those reasonable evaluation indeies, the coincidence of non-invasive with invasive risk prediction model was > 90% on average level. Conclusions This method could be used to develop non-invasive risk assessment model for the common diseases.

Objective:To observe the efficacy of acupuncture plus tuina therapy for insomnia.
Methods:Totally 100 eligible patients were randomized into a treatment group (n=51) and a control group (n=49) by using the random number table. The treatment group was intervened by acupuncture at Baihui (GV 20), Fengchi (GB 20), Wangu (GB 12), Shenting (GV 24), Anmian [Extra, locates at the midpoint between Yiming (EX-HN 14) and Fengchi (GB 20)], and Neiguan (PC 6) plus tuina treatment; the control group was intervened by acupuncture alone. For both groups, the treatment was given once a day, 10 sessions as a treatment course, and the efficacies were evaluated and compared after 3 treatment courses.
Results:Of the 51 subjects in the treatment group, 46 cases completed 3 treatment courses, and 17 cases were cured, 18 cases showed marked efficacy, 7 cases were improved, 4 cases had invalid result, and the total effective rate was 91.3%. Of the 49 subjects in the control group, 46 cases completed 3 treatment courses, and 8 cases were cured, 12 cases showed marked efficacy, 14 cases were improved, 12 cases had invalid result, and the total effective rate was 73.9%. The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05).
Conclusion:Acupuncture plus tuina can calm the mind and activate meridian qi in treating insomnia, and it can produce a more significant efficacy than pure acupuncture treatment.

Objective To study the value of blood glucose changes and the severity of the disease in patients with the systemic inflammatory response syndrome(SIRS).Methods In 328 SIRS patients without diabetes,intravenous blood glucose was monitored before open intravenou channel and subsequently 3~8h after intervals.The blood glucose was reviewed if glucose was abnormal 24h later.Results The blood glucose was higher than normal in 287(87.5%)patients with SIRS,of which 44 cases were death(13.4%).The higher the blood glucose level was,the higher the mortality rate was.Conclusion Blood glucose of patients with SIRS was elevated.If the blood glucose was 3 times higher than the normal,patients with SIRS had a higher mortality rate.

Objective To investigate the effects of early pregnancy exposure to hazardous indoor air pollutants due to interior decoration and hyperthermia on neurobehavioral development of postnatal rats.Methods Twenty-two pregnant rats were randomly divided into 4 groups.Each group was placed in pollutants cabinet,hyperthermia cabinet,hyperthermia+pollutants cabinet and empty cabinet respectively for 2 h per day for 10 d since their pregnancy.The weight and neurobehavioral development of postnatal rats were observed at different time points.The number of apoptotic and dead neurons in the CA1 region of hippocampus was observed in postnatal rats.The expression of the NR1 subunit of NMDA receptor of hippocampal neurons was also detected.Results Indoor pollutants and hyperthermia could accelerate apoptosis and necrosis of hippocampal neurons in CA1 region of postnatal rats and increase the expression of NR1 subunit of NMDA receptor.Furthermore,hazardous indoor pollutants and hyperthermia could induce remarkable influences on postnatal rats’ neurobehavioral development,learning and memory capability.Indoor pollutants combined with hyperthermia aggravated these effects.Conclusion Exposure to environment of the hazardous indoor pollutants especially combined with hyperthermia during early pregnancy has remarkable influences on the nervous system of postnatal rats.

[Objective]The clinical efficacy of endometriosis pelvic pain using traditional Chinese medicine in cycle treatment is discussed in the paper.[Methods] Forty patients of endometriosis diagnosed by chromatic colour type-B ultrasound or 1aparoscopy with typical dysmenorrhea were treated for three months in cycle therapy with traditional Chinese medicine based on dispersing liver,clearing away heat and activating blood circulation.The pain symptoms are evaluated before and after therapy per month.[Results]After three months treatment of traditional Chinese medicine,the diversified bellyache was significantly relieved and dysmenorrhea score was alleviated from 4.83?1.6 to 2.85?2.23(P

SUMMARY A 61-year-old male patient, with the history of premier myocardial infarction and CABG surgery, experienced recurrent unstable angina. Angiography showed triple vessel disease and vein grafts obstruction. The patient underwent a re-do OPCAB + TMLR + bone marrow mononuclear cell (BM-MNCs) transplantation on Nov. 8, 2004. BM-MNCs were isolated with standard gravity gradient method and the final implanted cell number was 12.06?108. Peri-operative data were similar to those of single OPCAB or re-CABG. The patient recovered promptly without recurrence of angina or infarction. Six-minute walking distance increased significantly (366 m to 493 m). Several imaging examinations reveal improved left cardiac function (LVEF improved from 23.75% to 52% in MRI) and diminished MI area. The results reveal that bone marrow cell transplantation, combined with TMLR and OPCAB is safe and might be effective in improving heart function for patients with IHD.

Probucol is a hypolipidemic agent with a unique pharm ac odynamic and clinical profile. It has a significant antiatherosclerogenic role a lthough it causes a marked decrease in serum high-density lipoprotein (HDL)-ch olesterol levels. The metabolism of HDL in vivois unclear. Some preliminary investigations suggest a beneficial effect in enhancing reverse cholesterol tra nsport which contributes to antiatherosclerosis of probucol. This paper reviews the mechanism of HDL-lowering effects of probucol.

Congenital cataract is responsible for approximately one tenth of childhood blindness worldwide.Generally,cataract includes three inheriting types:autosomal dominant,autosomal recessive or X-linked.The identified genes so far for hereditary cataracts in both human and animal model mainly include encoding structural lens protein,gap junction protein,membrane protein and regulatory protein involved in lens development.Crystallins are the major structural protein of the lens.Mutation in the crystallin genes can result in lens opacity.Understanding of the mechanism of hereditary cataract may also be helpful for us to understand the involvement of environmental and nutritional factors in the process of lens opacification.The function of the crystallins proteins,the mutations in crystallin genes and associated phenotypes are summarized.