1.Apolipoprotein E gene polymorphism and ischemic stroke
International Journal of Cerebrovascular Diseases 2013;21(9):693-696
Apolipoprotein E (ApoE) has gene polymorphism (ε2,ε3,and ε4).It has been confirmed that ApoE structural and functional abnormlities are closely associated with the hyperlipidemia,formation of atherosclerosis,and its severity,while both hyperlipidemia and atherosclerosis are the risk factors for ischemic stroke.In recent years,although the relationship between the ApoE gene polymorphism and ischemic stroke has been extensively studied,the conclusions are not consistent.This article reviews the correlation studies between the ApoE gene polymorphism and ischernic stroke.
3.Volatile constituents in the flowers of Elsholtzia argyi and their variation: a possible utilization of plant resources after phytoremediation.
Journal of Zhejiang University. Science. B 2005;6(2):91-95
Phytoremediation effectiveness and remediation costs are driving factors of this project. Full utilization of plant resources after their being used for phytoremediation is an unsolved problem. GC/MS technique was used to investigate the volatiles of the flowers from Elsholtzia argyi (PFE1: Purple Flower Elsholtzia) and their variation (WFE: White Flower Elsholtzia), naturally growing in Pb/Zn mined area, and Elsholtzia argyi (PFE2: Purple Flower Elsholtzia), naturally growing in Jiuxi uncontaminated agriculture soil. Seventeen compounds constituting 86.88% of total essential oils were identified in PFE1, with 2,6-octadienoic acid,3,7-dimethyl-methyl ester being the main constituent (63.30%). Sixteen compounds accounting for 95.32% of total essential oils were identified in WFE, with caryophyllene being the main component (55.02%). Compared to PFE1, PFE2 contains lower level of 2,6-octadienoic acid,3,7-dimethyl-methyl ester (31.76%), which is the main constituent in the total essential oils of PFE2. Caryophyllene is the main ingredient of flavor. Elsholtzia ketone was identified in all the three Elsholtzia plants. It can be concluded that the selected Elsholtzia argyi plants can be exploited on their versatile uses as fragrances and antiseptics due to the perfume ingredient and antibacterial components existing in their essential oils.
Agriculture
;
methods
;
Biodegradation, Environmental
;
Conservation of Natural Resources
;
Flowers
;
classification
;
metabolism
;
Lamiaceae
;
classification
;
metabolism
;
Oils, Volatile
;
analysis
;
metabolism
;
Plant Extracts
;
analysis
;
metabolism
;
Species Specificity
5.Significance of HER2 testing in breast cancer.
Yun-bi NI ; Wen-juan YANG ; Hong BU ; Hong ZHENG
Chinese Journal of Pathology 2011;40(2):76-78
Antibodies, Monoclonal
;
therapeutic use
;
Antibodies, Monoclonal, Humanized
;
Antineoplastic Agents
;
therapeutic use
;
Breast Neoplasms
;
drug therapy
;
metabolism
;
Carcinoma, Ductal, Breast
;
drug therapy
;
metabolism
;
Drug Delivery Systems
;
Female
;
Humans
;
Nitriles
;
therapeutic use
;
Receptor, ErbB-2
;
metabolism
;
Survival Rate
;
Tamoxifen
;
therapeutic use
;
Trastuzumab
;
Triazoles
;
therapeutic use
6.A study on the etiology of chest pain.
Yun Jun YANG ; Chul Hwan KIM ; Hong Gwan SEO
Journal of the Korean Academy of Family Medicine 1992;13(8):671-680
No abstract available.
Chest Pain*
;
Thorax*
7.Gama-aminobutyric acid accumulation in Elsholtzia splendens in response to copper toxicity.
Xiao-e YANG ; Hong-yun PENG ; Sheng-ke TIAN
Journal of Zhejiang University. Science. B 2005;6(2):96-99
A solution with different Cu supply levels was cultured to investigate gama-aminobutyric acid (GABA) accumulation in Elsholtzia splendens, a native Chinese Cu-tolerant and accumulating plant species. Increasing Cu from 0.25 to 500 micromol/L significantly enhanced levels of GABA and histidine (His), but considerably decreased levels of aspartate (Asp) and glutamate (Glu) in the leaves. The leaf Asp level negatively correlated with leaf Cu level, while leaf GABA level positively correlated with leaf Cu level. The leaf Glu level negatively correlated with leaf GABA level in Elsholtzia splendens. The depletion of leaf Glu may be related to the enhanced synthesis of leaf GABA under Cu stress.
Copper
;
toxicity
;
Dose-Response Relationship, Drug
;
Drug Tolerance
;
physiology
;
Gene Expression Regulation
;
drug effects
;
Lamiaceae
;
drug effects
;
metabolism
;
Plant Leaves
;
drug effects
;
metabolism
;
gamma-Aminobutyric Acid
;
metabolism
9.Clinical Characteristic of 34 Patients with Extranodal Nasal Type NK/T-Cell Lymphoma
Bo NIE ; Yun ZENG ; Yuntao LI ; Liyin LI ; Hong YANG
Journal of Kunming Medical University 2016;37(6):123-126
Objective Analysis of clinical features and treatment of nasal type NK/T cell lymphoma, to improve the understanding of this special type of lymphoma.Method The clinical data of 34 patients with nasal type NK/T cell lymphoma confirmed by pathology were retrospectively analyzed.Result In 31 cases, 26 cases were EB virus (EBV) infection positive, recent Treatment Effectiveness in the positive group was significantly lower than the negative group (38.46%vs. 87.50%;P<0.05) . Follow up showed until October 2015, 19 of 34 patients died. Among them, 17 cases died of disease relapse or progression, 2 cases died of other diseases. 15 patients survived (11 of them were disease-free) and the median overall survival time was 37 months. The 2 year overall survival was related to clinical stage, B symptoms, EBV infection (the P values were 0.017/0.001, 0.005, and 0.039 respectively).Conclusion EBV infection is associated with patient's treatment response in NK/T-Cell Lymphoma; and the prognosis is associated with clinical features such as clinical stage, B symptom, and EBV infection.
10.Dectection of p16~(CDKN2A) exon 1 methylation in experimental tongue carcinogenesis in rats
Bin CHENG ; Yun HONG ; Chunyang LI ; Hongbin XIA ; Linglan YANG
Journal of Practical Stomatology 1995;0(04):-
Objective: To detect methylation status of p16 CDKN2A exon 1 during experimental carcinogenesis in rats. Methods:Thirty male clean SD rats were fed with 0.02 g/L of 4-nitroquinoline-oxide (4NQO) in drinking water.13, 16 and 24 weeks after experiment the normal, moderate-severe dysplasia and invasive squamous cell carcinoma tissues were removed from their tongues respectively; then the methylation status of p16 CDKN2A exon 1 were detected by methylation-specific PCR(MSP). Results:A 123 bp-unmethylated product was amplified in all samples but the methylated product was not detected in any of the samples. Conclusion: The p16 CDKN2A exon 1 appeares to be unmethylated during carcinogenesis of tongue cancer in experimental rats.