BACKGROUND: Sulfonylurea is recommended to be taken before meal. But since premeal administration is against Koreans usual medication habit, it can be the cause of poor compliance. Such recommendation is based on the results of a few clinical trials about appropriate medication time. But most of the clinical studies had a limitation : observe only acute effects of medication, subjects were only healthy volunteer. So the chronic effect of sulfonylurea of each kind must be validated. METHODS: From 1996 May to 1996 July, data were collected from diabetic patients who visited an university hospitals for managing diabetes and used a intermediate-acting sulfonylurea. The subjects were randomized to two groups of premeal group and postmeal group, by chart number and were asked to take the previous medicine according to assignment. After 1 month medication, mixed meal tolerance test was done with 300Kcal carbohydrate, 400+/-50Kcal diet. The subjects were switched to the other group and 2nd mixed meal tolerance test was done 1 month later. The Area under curves was calculated in preand post-prandial glucose curve and was compared by paired t-test. RESULTS: During the study period, total 16 diabetic patients were enrolled. There was no significant statistical difference between pre-prandial group and post prandial group in AUC. CONCLUSIONS: Intermediate-acting sulfonylurea can be administered at any time in relation to meaL.
Area Under Curve ; Compliance ; Diet ; Eating* ; Glucose ; Healthy Volunteers ; Hospitals, University ; Humans ; Meals

Forty-three patients with papulo-pustular rosacea with Demodex(D.) folliculorum were treated for 8 weeks on a random basis either with tetracycline 250 mg three times daily or with metronidazole 250 mg three times daily. Both drugs produced an improvement which was greater after 8 weeks than after 4 weeks, but there was no significant difference between them. The number of D. follilculorum after treatment with tetracycline was slightly decreased, but the number of D. folliculorum after treatment with metronidazole was more decreased than the tetracycline group. Metronidazole appears to be a effective drug for the treatment of rosacea with D. folliculorum.
Humans ; Metronidazole* ; Rosacea* ; Tetracycline*

No abstract available.
Blood Donors* ; Humans

No abstract available.
Blood Donors* ; Humans

Lichen planus is rare in Korea and localized lichen planus on the lip without other skin lesions is even rarer. A 77-year-old man has oozing and crusting patches und somewhat ulceration surrounded by whitish reticular elements on violaceous base on both lips with burning sensation and pain. A 63-year-old man has well demarcated violaceous white reticular patches on the lower lip, buccal mucosa, glans penis and coronal sulcus. Clinical and histopathological studies of two cases showed typical features of lichen planus. They were treated with systemic and topical corticosteroids and showed much improvement.
Adrenal Cortex Hormones ; Aged ; Burns ; Humans ; Korea ; Lichen Planus* ; Lichens* ; Lip* ; Male ; Middle Aged ; Mouth Mucosa ; Penis ; Sensation ; Skin ; Ulcer

The important prerequisite for treatrnent of onychomycosis is the removal of as rnuch fungus-infected nail material as possible. Nincty-five patients with anychomycosis were treated with using urea preparations under occlusive dressings. The urea preparations were quite successful in maceraing the nail plate from the nail bed, allowing the easy removaI of diseased nails in all cases except one. The urea preparations removed only abnormal nail. Completely normal nail was unaffected. After nail avulsion, 95 patients were treated for 6 months with combination clotrimazole and ketoconazcile(group A), or with clotrimazole only(group B). Of the 38 patients in group A who complcted the treatment, 25(65.8%) were cured 6 months later by clinical and mycological criteria, compared to 20(47.6%) of 42 patieries in group B.
Clotrimazole ; Humans ; Ketoconazole ; Nails, Malformed ; Occlusive Dressings ; Onychomycosis* ; Urea

Supersoft roentgen rays called grenz rays, generated in a tube at low voltages and having wave lengths of 1 to 3 angstroms(H.V.L. 0. 01 to 0. 035mm. Al. ), are employed in the treatment of superficial derrnatoses patients (112 cases) in the Department of Dermatology, Cho Sun University hospital from March 1, 1972 to April 30, 1974. Results of these Series are as Follows: 1) Among the ll2 patients, including 28 patients of neurodermatitis, 14 patients of nummular eczema and. 10 patients of atopic dermatitis showed therapeutic success. 2) Grenz ray irradiations were remarkably effective for 6 cases of capillary hemangioma, 2 cases of basal celI epithelioma and 3 cases of verruca plana juvenilis, and less effective for psoriasis vulgaris, tinea pedis, acne vulgaris, nevus verrucosus and alopecia areata. 3) Complications included 21 cases of hyperpigmentation and burning sensations in neurodermatitis and nummular eczema.
Acne Vulgaris ; Alopecia Areata ; Burns ; Carcinoma ; Dermatitis, Atopic ; Dermatology ; Eczema ; Hemangioma, Capillary ; Humans ; Hyperpigmentation ; Neurodermatitis ; Nevus ; Psoriasis ; Sensation ; Solar System ; Tinea Pedis ; Warts

Influence of acute and chronic carbon monoxide poisoning on the rat prostate has been studied enzymologically and the following results were obtained: 1. An increasing tendency of the total lactate dehydrogenase activity in the prostate tissue was observed is the chronic poisoning groups. 2. The lactate dehydrogenase isoenzyme distribution pattern was not remarkably influenced by chronic poisoning. 3. The lactate dehydrogenase isoenzyme distribution pattern is the prostate tissue was as LDH5> LDH4> LDH3> LDH2> LDH1.
Animals ; Carbon Monoxide Poisoning* ; Carbon Monoxide* ; Carbon* ; L-Lactate Dehydrogenase* ; Lactic Acid* ; Poisoning ; Prostate* ; Rats*

Influence of acute and chronic carbon monoxide poisoning on the rat testis has been studied enzymologically and the following results were obtained: Experimental animals were divided as 1) control, C1 (6 animals) 2) acute poisoning with 0.5% carbon monoxide until death, C2 (10 animals) 3) chronic poisoning with 0.05% carbon monoxide for 2 hours daily E1 (5 animals)...3 days/week for 8 weeks E2 (6 animals)...3 days/week for 4 weeks 4) acute poisoning until death with 0.5% carbon monoxide after chronic poisoning with 0.05% carbon monoxide E3 (5 animals)...chronic poisoning for 8 weeks plus acute poisoning E4 (5 animals)...chronic poisoning for 4 weeks plus acute poisoningUsing Neiland's method, the total activities and distribution patterns of lactic dehydrogenase in rat testis were measured. All of the data were analyzed statistically. 1. The total activities of lactic acid dehydrogenase in all experimental groups seemed to increase. In the group E3, the increase was statistically significant.(p<0.05) 2. No significant changes were observed in the lactic acid dehydrogenase isoenzyme distribution pattern of the testis. both is the control and experimental groups. 3. The lactic acid dehydrogenase distribution patterns were as fraction l>2>4>3>5 4. No significant histopathological changes were observed in the rat testis.
Animals ; Carbon Monoxide Poisoning* ; Carbon Monoxide* ; Carbon* ; L-Lactate Dehydrogenase* ; Lactic Acid* ; Oxidoreductases ; Poisoning ; Rats* ; Testis*

No abstract available.
Hepatitis B* ; Hepatitis* ; Vaccination*