Objective To investigate the clinical efficacy of fire needle puncture combining with chinese herbal medicine for treating sciatica. Methods Sciatica outpatients were randomly allocated to a Fire needle puncture plus chinese herbal medicine of 37 cases( treatment group) and a western medication group of 32cases( comparison group). In the former, fire needle puncture and chinese herbal medicine was performed for two or three treatment courses; in the latter, only western medication was given during the same period. Results A comparison of the curative effects at one day after the treatment showed that the marked efficacy rate and effective rate in the treatment group were 78.4% and 97.20% respectively, and in the comparison group was 43.8% and 84.4%. The comparison of the curative effects between the two groups showed that all these patients got better in the treatment group than in the comparison groups and there was very significant difference ( P

OBJECTIVE:To investigate the effects of clopidogrel plus atorvastatin on ischemic cardiovascular diseases and to explore the clinical significance of drug interactions.METHODS:Literatures were retreived from EMBase,PubMed,Cochrane Library and CNKI with clopidogrel,atorvastatin,clinical trial as

ve To investigate the effects of different doses of diltiazem alone or combination with isoflurane on stunned isolated rat heart. Methods Adult male Wistar rats weighing 325-350g were anesthetized with intraabdominal pentobarbital sodium 60mg?kg-1. Heparin 200IU was injected into femoral vein. Chest was then opened and heart was removed and connected to Langendorff preparation. The isolated rat heart was perfused at 100cm H2O with Krebs-Hensleit buffer(KHB) balanced with 95%O2 and 5%CO2 at 37℃ and electrically paced at 300 bpm. Global myocardial ischemia was produced by suspension of perfusion. The isolated rat heart underwent 20 min ischemia followed by 30min reperfusion. 40 rat hearts were randomly allocated to one of 5 groups of eight each, group Ⅰ received no treatment and served as control; group Ⅱ: the isolated heart was perfused with 0.1/?mol?L-1 diltiazem for 10 min before the onset of ischemia; group Ⅲ: with 0.5?mol?L-1 diltiazem; group Ⅳ: with 0. 1?mol?L-1 diltiazem + 1.5MAC isoflurane; group Ⅴ: with 0.5?mol?L-1 diltiazem + 1.5MAC isoflurane. Left ventricle developed pressure(DP) was measured from a fluid-filled Latex balloon placed in left ventricle. The volume of the fluid in the balloon was regulated to maintain the left ventricle end-diastolic pressure at 5-8 mm Hg. Peak systolic pressure(PSP), end-diastolic pressure(EDP) and developed pressure(DP) were measured after the isolated heart was stabilized for 10min (baseline value) and 5, 10, 15, 20, 25, 30min after reperfusion. Maximum intraventricular pressure was measured during ischemia when the isolated heart was not paced and at a stand still. Results There was no significant difference in DP, EDP, + dp/dtmax and - dp/dtmin after the isolated hearts were stabilized for 10min, before ischemia among the five groups. Perfusion with 0.1?mol?L-1 diltiazem did not affect DP significantly but 0.5?mol?L-1 diltiazem significantly decreased DP (P

OBJECTIVE To explore optimal change dressing of the incision of trachea.METHODS Seventy-eight patients were randomly and equally divided into the traditional group and test group.In traditional group,after dressings change with conventional disinfection,the sterile gauze was cut into "E" shape and overlapping covered on the incision of trachea around the trachea cannula from top to bottom and fixed with adhensive plaster.In test group,after dressings change with conventional disinfection,the special sterile drainage was fixed and smoothed around the trachea cannula from left to right(or from right to left).RESULTS In test group,skin incision colonies of patients were significantly lower than that in traditional group(P

0.05).Conclusion The therapeutic mechanism of AEP of Chinese herbal medicine for asthma may be related with the inhibition of EOS infiltration,the decrease of peripheral IL-4 content and the increase of IFN-?.

Child ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Phytotherapy ; Pneumonia, Mycoplasma ; diagnosis ; drug therapy

Objective To investigate the effects of rosiglitazone on the endothelial regeneration and neointimal formation after balloon injury in rat aortic.Methods Endothelial denudation of aorta in SD rats were performed with 2 F Fogarty balloon catheter.Male Rats were randomly divided into the sham-operated group,the control group,and the RSG group.Aortic tissues were harvested 7 days and 14 days after the injury.The endothelial regeneration rate,serum NO level,IA/MA ratio and PCNA expression index were detected.Results RSG enhanced the reendothelialization of the injured aorta determined by Evans blue staining.The RA/TA ratio on the 7~(th) day and the 14~(th) day were 38.20% and 75.20%(P

[Objective] To observe the effect of Pueraria Lobata isoflavones (PLI) on neuropeptide-Y-induced (NPY) vascular smooth muscle cell (VSMC) proliferation. [Methods] Experiment system for VSMC was set up as 4 groups: control group (with DME culture fluid, free of blood serum; group A), model group (with NPY culture fluid; group B), control + PLI group (with PLI culture fluid; group C) and model + PLI group (with NPY and PLI culture fluid; group E). Quantitative fluoroimmunohistochemistry techniques were applied to examine the mean fluorescent values of proliferating cell nuclear antigen (PCNA), platelet derived growth factor (PDGF) and C-myc expression. [Results] The levels of PCNA, PDGF and C-myc expression in model group were higher than control group (P

AIM: To investigate the effects of pueraria lobata isoflavones (PLIs) on neuropeptide-Y(NPY)-induced myocardiac cell hypertrophy in vitro. METHODS: Rat cardiomyocytes cultured in vitro were randomized to control, NPY, NPY+PLIs and PLIs group. The protein synthesis in cardiomyocytes was assessed by [~3H-Leu] uptake, C-jun mRNA by RT-PCR and CaN activity by histochemistry. RESULTS: The rate of [~3H-Leu] uptake, the C-jun mRNA expression and the CaN activity of myocardiac cells in 100 nmol/L NPY group were higher than those in control (P