Heterogeneity in clinical features and pathogenesis of non-steroidal anti-inflammatory agent (NSAIDs) hypersensitivity have been reported. NSAIDs can cause bronchial constriction in asthmatics or hives and angioedema in patients with chronic urticaria, in which case causative drugs show cross-reactivity with other NSAIDs. Normal subjects without allergic diseases may develop urticaria angioedema or anaphylaxis after ingestion of a specific NSAID. In this type of reaction, cross-reactivity between causative drugs and other NSAIDs does not occur. We experienced a case of acetaminophen anaphylaxis without aspirin sensitivity in a 38-year-old male, which was confirmed by oral provocation test. An oral challenge with 150mg of acetaminophen induced urticaria in lower legs, and erythema, with febrile sensation in ears. With a dose of 600mg acetaminophen, urticaria developed in trunk and extremities with facial angioedema. An oral provocation test with 650mg of aspirin was well tolerated without any adverse reactions. We report acase of acetaminophen anaphylaxis, which occurred in a normal individual at a small dose(150mg) without cross-reactivity with aspirin. This type of reaction supports heterogenei~ty of NSAIDs hypersensitivity and it may be caused by an other mechanism, not by cyclooxygenase inhibition.
Acetaminophen* ; Adult ; Anaphylaxis* ; Angioedema ; Anti-Inflammatory Agents, Non-Steroidal ; Aspirin* ; Bronchoconstriction ; Ear ; Eating ; Erythema ; Extremities ; Humans ; Hypersensitivity ; Leg ; Male ; Population Characteristics ; Prostaglandin-Endoperoxide Synthases ; Sensation ; Urticaria

OBJECTIVE: The aim of this study was to investigate the usefulness of serum ECP as a marker of the severity of asthma and extent of airway inflammation. METHOD: We investigated 108 patients suffering from bronchial asthma, who were classified as mild intermittent(n=19), mild persistent(n=27), moderate persistent(n=42), and severe persistent(n=20) and 10 healthy controls. Atopy was defined as those who showed >2+ responses on skin prick test. Serum ECP, peripheral blood eosinophil, sputum eosinophil, and PEFR were measured on the same date and meth~acholine PC20 were determined within 2 weeks. RESULTS: Serum ECP levels were 10.1+- 2.0 ug/L in controls, and 29.1+- 23.6 ug/L in asthmatic patients. According to symptom severity, serum ECP levels were 22.9 +- 15.6 ug/L, 28. 6 +- 24.1 ug/L, 29.5 +- 22.2 ug/L, and 34.6 +- 31.2 ug/L in mild intermittent, mild persistent, moderate persistent and severe persistent asthmatic patients, respectively and there were no significant differences among four groups(p>0.05). Serum ECP levels correlated with peripheral blood eosinophil counts(r=0.48, p<0.01), but not with sputum eosinophil, PEFR, and methacholine PC20 levels. There was no significant difference in serum ECP level between atopic and non-atopic asthma(p>0.05). CONCLUSION: Single measurevment of ECP level at clinic could not represent the severity of asthma.
Asthma* ; Eosinophil Cationic Protein* ; Eosinophils* ; Humans ; Inflammation ; Methacholine Chloride ; Peak Expiratory Flow Rate ; Skin ; Sputum

No abstract available.
Heart Septal Defects, Ventricular* ; Oximetry*

From January to December 1984, 191 patients with associated ventricular septal defect(VSD) were studied in the cardiac cathetherization laboratory. Among theses 191 cases, 58 cases(30.4%) of subpulmonic VSD were identified by angiocardiography. Among the 59 cases of subpulmonic VSD, 12 cases(20.6%) were complicated with aortic infficiency(AI). The relative frequency of subpulmonic VSD increased with the increase of age and the frequency of complication of AI with the subpulmonic VSD also increased with the increase of age. The amount of left to right shunt in the patients with subpulmonic VSD and AI was small and Qp/Qs ratio was less than 2.0 in all of the 12 cases. Among the 12 patients 4 cases had a pressure gradient greater than 20 mmHg across the infundibular region of the right ventricle.
Angiocardiography ; Heart Septal Defects, Ventricular* ; Heart Ventricles ; Humans

No abstract available.
Cardiac Tamponade* ; Leukemia, Myeloid, Acute*

Joints ; Mandible ; Maxilla ; Orthognathic Surgery ; Recurrence ; Skull

No abstract available.
Angiofibroma*

Background: Erythropoietin (EPO), which is associated with anemia, exerts neuroprotective effects in ischemic stroke. In cases of stenosis or narrowing of the main cerebral blood vessel, the prognosis is favorable if collateral blood circulation is well developed in acute stroke. Several studies have investigated the relationship between EPO administration and stroke outcomes. The present study investigated the correlation between serum EPO level and cerebral collateral circulation, which could result in favorable clinical outcomes. Methods: The study subjects were patients diagnosed with acute ischemic stroke who underwent initial brain magnetic resonance imaging between January 2020 and March 2022. Following brain computed tomography perfusion for collateral flow, serum EPO levels were measured. Collaterals were assessed according to the Mass system and divided into good collateral (GC) or poor collateral (PC) groups. Serum EPO levels were determined using a chemiluminescence immunoassay method. A correlation coefficient analysis was conducted to determine the correlation between serum EPO levels and GC. A receiver operating characteristic curve analysis determined the cutoff value of EPO for GC. Results: Serum EPO levels were significantly higher in the GC than that in the PC group (P<0.05). The cut-off level of serum EPO for a good outcome was 9.1 mIU/mL. Conclusion A high serum EPO (>9.1 mIU/mL) could be a marker of GC in patients with acute ischemic stroke that predicts good clinical outcomes.

Neovascular glaucoma is considered to be one of the most difficult forms of glaucoma to control. In neovascular glaucoma fibrovascular tissue grows over the surface of the iris and trabecular meshwork. Many modified filtering surgery with artificial drainage devices have been tried in attempts to maintain openings for aqueous humor to leave the eye. Modified trabeculectomy was performed with inexpensive easily available simple silicone tube in 8 eyes with neovascular glaucma. Of the 8 eyes, 6 had postopeoative intraocular pressures lower rhan 25mmHg through a mean follow-up period of 6 months.
Aqueous Humor ; Drainage ; Filtering Surgery ; Follow-Up Studies ; Glaucoma ; Glaucoma, Neovascular* ; Intraocular Pressure ; Iris ; Silicones ; Trabecular Meshwork ; Trabeculectomy*

We performed case-control studies for the 1, 138 Korean adult men. According to the results of UGIS, we classified the gastritis into the erosive gastritis, superficial gastritis, and hypertrophic gastritis. And then, we selected controls among non-gastritis group after matching. Alcohol intake and smoking history was obtained by questionnaire. And we observed the effects of alcohol intake and smoking to the each gastritis. The results obtained were as follows; 1. Smokers had a risk of getting erosive gastritis more than twice (2.6) than non-smokers and there was dose-response relationships between smoking and erosive gastritis. Alcohol intake, however, had no significant relation with the erosive gastritis. 2. Both smoking and alcohol intake had no significant relations with superficial gastritis. 3. Smoking had no significant relation with hypertrophic gastritis, but dividing between those who drank more than 100gm of alcohol a week and those who drank less, we obtained the odds ratio of 3. 4 suggesting that there existed a significant relation between moderate or excessive alcohol intake and hypertrophic gastritis. 4. Among the gastritis patients, those who had erosive gastritis smoked most heavily, and those who had hypertrophic gastritis drank most excessively.
Adult* ; Case-Control Studies* ; Gastritis* ; Gastritis, Hypertrophic ; Humans ; Male ; Odds Ratio ; Surveys and Questionnaires ; Smoke* ; Smoking*