3.Qiangguyin strengthens periprosthetic bone density after hip arthroplasty:a randomized controlled half-year evaluation
Zhifei JIAN ; Wei SUN ; Hong CAO
Chinese Journal of Tissue Engineering Research 2015;(39):6286-6290
BACKGROUND:Hip arthroplasty is an effective means currently in repair of femoral neck fractures. With the increased in the amount of surgery, surgery failure rate also has increased. In particular, prosthesis loosening and fracture are very common after replacement.Qiangguyin can promote the formation of osteoblasts, resist osteoporosis, inhibit osteoclast activity, and increase bone density. Drynaria invigorates the kidney, strengthens the bone and tendon and relieves pain, and has bidirectional regulatory effects on promoting bone formation and inhibiting bone resorption.
OBJECTIVE:To investigate effects ofQiangguyin on periprosthetic bone density in patients with femoral neck fracture after hip arthroplasty.
METHODS:96 patients with femoral neck fracture were equaly divided into observation group and control group based on the random number table. Both groups were given selective joint replacement. Patients were implanted with femoral head made by US Stryker Corporation, and fixed with bone cement. After replacement, patients in the control group were treated with calcium D3 tablets and capsules alfacalcidol. On this basis, the treatment group was given theQiangguyin oral drug intervention for a month. Bone density surrounding the prosthesis was observed in both groups. Alkaline phosphatase and tartrate-resistant hydrochloric acid phosphatase activities were detected. Repair effects were compared.
RESULTS AND CONCLUSION:The surgery was successfuly completed in al patients. No infection or loosening of the prosthesis occurred. Ambulation time and healing time were significantly less in the observation group than in the control group (P < 0.05). No significant difference in bone density surrounding the prosthesis was detected between the two groups before medication, and an obvious increased trend was found after medication (P < 0.05). Bone density was significantly higher in the observation group than in the control group after medication (P < 0.05). Serum alkaline phosphatase activity was significantly higher in the two groups after medication, but tartrate-resistant hydrochloric acid phosphatase activity was significantly decreased, which showed significant differences as compared with that before medication (P < 0.05). Simultaneously, significant differences in serum alkaline phosphatase activity and tartrate-resistant hydrochloric acid phosphatase activity were detected between the observation and control groups after medication (P < 0.05). At 6 months after replacement, the excelent and good rate of joint function was significantly higher in the observation group than in the control group (94%, 79%,P < 0.05). These results indicate that Qiangguyin could resist bone resorption and suppress excessive bone turnover, improve bone density around the prosthesis, and restore joint function after hip arthroplasty.
5.One case of dermatomyositis with hoarseness and dyspnea as first symptom.
Xu-dong WEI ; Yong-hong WEI ; Jian HE
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2012;47(5):427-427
Aged
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Dermatomyositis
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complications
;
diagnosis
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Dyspnea
;
diagnosis
;
etiology
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Female
;
Hoarseness
;
diagnosis
;
etiology
;
Humans
6.Effect of Early Rehabilitation on Motor and Cognitive Function of Hemiplegia after Stroke
Wei WANG ; Ying-hong XUE ; Jian-feng REN ; Juan WEI
Chinese Journal of Rehabilitation Theory and Practice 2006;12(5):413-414
ObjectiveTo study the effect of early rehabilitation on disability of motion and cognition.Methods107 patients were randomly divided into two groups,rehabilitation group (51 cases) and control group (56 cases).Patients in rehabilitation group were given regular early rehabilitation,while all patients in both groups were given usual clinical treatment. The Barthel Index (BI), Fugl-Meyer Assessment (FMA), Mini-mental Status Examination (MMSE) were used to evaluate these two groups before and 3 months after treatment. ResultsAfter treatment, the scores of BI, FMA and MMSE were improved significantly(P<0.05) in rehabilitation group compared with that before treatment, so did that of BI, FMA in control group(P<0.05).The scores of BI、FMMS、MMSE in rehabilitation group improved significantly compared with that in control group(P<0.05).ConclusionEarly rehabilitation may obviously improve the motive and cognitive function and increase the quality of living of hemiplegia after stroke.
7.Progress in Mucosal Adjuvants
Hong-Li ZHOU ; Li GUO ; Jian-Wei WANG ; Tao HONG ;
China Biotechnology 2006;0(03):-
Mucosal adjuvants play important roles in vaccine development. By now, the common used mucosal adjuvants can be divided into three categories: the bacterial derivatives, cytokines and chemokines, and antigen delivery systems. Progresses of the three kinds of adjuvants were reviewed to give a reference to novel vaccine research.
8.Immunogenicity of Different Genetic Type Rotavirus NSP4 in Mice
Da-Yan WANG ; Jian-Wei WANG ; Qiang WEI ; Yan-Bin WANG ; Jian-Guo QU ; Tao HONG ;
China Biotechnology 2006;0(04):-
NSP4, as the diarrhea-related protein of rotavirus, is becoming an attractive candidate for vaccine development. To compare the immunogenicity of NSP4 from different genetic groups, we constructed eukaryotic expression plasmids comprising the NSP4 genes from four different genetic types using the pCI vector. The recombinant vectors were designated as pCI-97B6, pCI-97S36, pCI-97S34 and pCI-97SZ8, respectively. Following the conformation of the transient expression of the constructs in 293 cells, the plasmids were respectively subjected to the 5 round i. m. inoculation of BALB/c mice. The specific antibodies against NSP4 as well as the IgG1/IgG2a subclasses of immunoglobulin in mice sera were examined with indirect ELJSA after each immunization. The results showed that the immunization of plasmids expression NSP4s could elicit not only humoral but also cellular immunity, but the humoral immune response is dominant. There is a difference of immunogenecity among the NSP4 of different genetic type. Further studies were needed to focus on the relationship between the immunogenicity and protection effect.
9.Clinical analysis of digestive tract malignancies treated with iodine-125 interstitial brachytherapy.
Juan WANG ; Wei-Hong GONG ; Jian-Bin XU
Chinese Journal of Oncology 2008;30(2):153-154
Adult
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Aged
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Aged, 80 and over
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Brachytherapy
;
adverse effects
;
methods
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Digestive System Neoplasms
;
radiotherapy
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Esophageal Neoplasms
;
radiotherapy
;
Female
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Fever
;
etiology
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Follow-Up Studies
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Humans
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Iodine Radioisotopes
;
therapeutic use
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Male
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Middle Aged
;
Nausea
;
etiology
10.Successful treatment of a patient with craniocervical penetrating injury by a steel bar.
De-zhi YU ; Jian-xin QIU ; Hong-wei CHENG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2012;47(5):424-424
Adult
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Fluoroscopy
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Foreign Bodies
;
therapy
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Humans
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Male
;
Trauma, Nervous System
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therapy
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Wounds, Penetrating
;
therapy