Researching in test mouse. Result: In vivo, Honeysuckle flower have a acute anti-inflammatory effect when used alone as well as its combination with alpha-CT. In vitro, honeysuckle flower have a stimulate effect of the activity alpha-CT. The successful combination of decoction and honeysuckle flower (flavonoid) with alpha-CT(in vitro and in vivo) took a little part in studying the anti-inflammatory mechanism of honeysuckle flower with alpha-CT. The synergic effect of above two active element induced which give satisfactory anti-inflammatory effect, which was equivalent to some of modern medicine of use to anti-inflammatory drug.
Flowers ; Anti-Inflammatory Agents ; Flavonoids

Pseudomonas aeruginosa is resistant many antibiotics currently, including new generation, broad spectrum antibiotics that were very effective with other bacteria. Thus, it's difficult to treat P. aeruginosa infection with these antibiotics. Author collected P. aeruginosa strains from some hospitals in Hanoi, tested with more antibiotics in order to determine antibiotic resistant rate and types, to orient some mechanisms of antibiotic resistance of P. aeruginosa. Materials is 97 strains of P. aeruginosa isolated from blood and pus of patients treated at Bach Mai Hospital and National Institute of Burn from August 2002 to November 2003. Method: disk diffusion antibiotic sensitivity testing (Kirby - Bauer test). Results: Isolated P. aeruginosa strains are multiple antibiotic resistant (8 of 16 antibiotics), especially hospital infection strains are resistant 100% of tested antibiotics. It showed the potential roles of some enzymes such as penicillinase, cephalosporinase, AAC(6), ANT(2")-1, and ANT(2") enzymes that inhibit effects of antibiotics in bacterium cell
Anti-Bacterial Agents ; Pseudomonas aeruginosa ; Drug Resistance, Microbial

In the period from Aug 2002 to Aug 2003, at the National Institute of Burn strains of S. aureus and 45 strains of P.aeruginosa were isolated from the blood of severious septicemia patients.In disk diffusion test,100% of S.aureus strains were resistant to penicillin, erythromycine, kanamycine, tobramycine, gentamycine, oxacilline, 36% in particular, resistant to vancomycine and 45% to teicoplanine. 100%,of P.aeruginosa were resistant to ticarcilline, cefoperazol, gentamycine, tobramycine and 50% were resistant to ciprofloxacine.The most common effective combinations were rifampicine+acide fusidic, or rifampicine+ vancomycine for S. aureus, and imipenem + fosfomycine or imipenem+netilmycine, or imipenem +piperacillin/tazobactam for P.aeruginosa
Anti-Bacterial Agents ; Therapeutics ; Burns ; Infection

Background: In a chemical war during 1961-1971, about 94,000 tons of the herbicides were sprayed over Southern Viet Nam.A main component of the herbicides is dioxin that is very harmful to humans. There are many studies focusing on people\u2019s health due to exposure to dioxin residuals. Objective: To investigate the health issues related to exposure to dioxin residuals. Subjects and method: A retrospective comprehensive survey performed on 4018 people in Cam Chinh commune, Cam Lo district, Quang Tri province and compared with 3987 people in Cam Phuc commune, Cam Xuyen district, Ha Tinh province (controls) based on epidemiological interviews. Results: The morbidity was higher at 6.4% in the herbicides-applied area than in the herbicides-non applied area. In herbicides-applied area, there was a high risk of diseases such as bone connective, genitourinary, blood endocrine system, skin and infectious diseases. Factors such as age, sex, familiar income, drinking, smoking and agricultural chemical usage contributed towards the health of the affected population.Conclusions: Agent orange/dioxin pollutions still have the potential to be hazardous to human health in the herbicides-applied areas.
Dioxin ; agent orange ; disease

Background: Dioxin affects nervous system via the system of nervous communicative hormones and endocrine hormones, causing disorders and nervous behavior wrongs. Reproductive health is one of the serious effects of exposing Agent Organe/Dioxin. Objectives: To evaluate the birth defects of the nervous system of children, from the generation of veterans exposed to Agent Orange/Dioxin during wartime and to assess congenital nervous defects related factors, characteristics in these subjects. Subject and methods: A retrospective cohort, interview and examine 12.369 exposed and 7.659 unexposed Hanoi veterans, their birth defective children were examined by the pediatrics. During the 2002-2003 timescale. Results: A statistically high significant rate of reproductive failures and birth defects for exposed veterans, compared to unexposed ones, spontaneous abortion with relative risk RR = 4.18, hydatidiform mole with RR = 3.0, still births with RR = 2.2, birth defects with RR = 2.12. Nervous birth defects were highest; representing more than 40% of live births; the relative risk of the exposed group is 2.3 fold higher than the unexposed group, with p < 0.01. The birth defects increased significantly: mild mental retardation with RR = 3.5, severe mental retardation with RR = 3.5, Down's syndrome with RR = 2.16. Conclusions: Nervous birth defects of children of the Hanoi veterans exposed to Agent Orange during wartime accounted for the highest rate. Congenital nervous defects in male were higher than female. Exposed time, exposed levels and direct exposure to Agent Orange were significant related factors in this study. The increase of birth defects was in correlation with exposed levels.
congenital nervous defects ; birth defects ; veterans

In the period from 1995 to 1997, this simple method was performed at the Institute of Mothers and Neonates Protection and Care in 107 female subjects to investigate the endocrinological function. The method is preferable in the early stage of menstrual cycle, especially for retrospective diagnosis to check the response to the treatment.
Menstrual cycle ; Biopsy

23 patients with mitral stenosid with or without mild mitral open, ages of 23-50 (male: 10) received an operation. As the results of direct measurement of pulmonary arterial pressure and left atrial pressure in an operation have shown that the pulmonary arterial pressure was direct correlated before and after operation(r= 0.572 before operation; r=0.65 after operation).These parameters were reduced significantly and rapidly after operation when comparing with these before operation.
Evaluation Studies ; Thoracic Surgery ; Mitral Valve Stenosis

23 patients (10 males, 13 females) with mitral stenosis aged from 23-50 years of old (mean 37.5 years) were enrolled in the study. Valvular opening area ranged from 0.7cm2 to 1.2cm2. 5 patients have mitral stenosis alone. 18 patients have mitral stenosis with insufficiency grade I, II. 14 patients have sinus rhythm and 98 patients have atrial fibrillation. Pulmonary artery pressure ranged 25mmHg to 45mmHg when measuring directly. There was closed positive correlation between pulmonary artery pressure and right ventricular pressure with r= 0.509 for pre-operation and 0.548 for post-operation. After valve detachment, both pulmonary artery pressure and right ventricular pressure decreased rapidly and dramatically in comparison with prior detachment with p = 0.01.
Mitral Valve Stenosis ; Ventricular Pressure

A study was carried out on the 23 patients (male:10, female: 13) with the mitral stenosid with merely close or combination with the mild mitral open (grade III), ages of 23-50 indicated an operation for seperation of close valve in the Army Central hospital 108 during 1/1998 to 10/1999 in which there were 5 patients with the mitral stenosid, 18 patients with the mitral stenosid in combination with the mitral open grade I, II, 14 patients with the atrial rhythm, 9 patients with atrial fibrillation. The atrial pressure reduced from 15-67 mmHg to 15-45 mmHg. There was a direct proportional between the left atrial and right ventricular pressures
Mitral Valve Stenosis ; Ventricular Pressure ; surgery

Both of alpha-chymotrypsin and papain were active in hydrolysis of proteins by temperature, acid and alkali proteins. Alpha-chymotrypsin hydrolysed protein better than papain. They were effective in digestion of mouse protein in inflamed tissue by Kaolin, Dextran and Formal in different level according this increasing order: Kaolin < Dextran < Formal. -chymotrypsin was better than papaine in hydrolysis of protein in inflamed tissue. Therefore, we can explain the anti inflammatory characters of those enzymes.
Chymotrypsin ; Papain