Author observed histopathologically and immunologically the old lepers of 360 cases, having the duration of infection with average 11 years and 5months. Here summarize as follows : 1. Microscopically in L-type, lepra cells, or Virchow cells (foamy cells) were relatively large, and the infiltration showed the tendency to concentrate particularly around the periglandular regions. Free zones were mostly obscure and disappeared. 2. Tuberculoid structure tends to be obscured in T-type of leprosy. 3. The healings showed few granulomatous infiltration, rather the almost normal findings. But periglandular and perivascular infiltrates were present. 4. Lepromin test was considerably positive in T-type of leprosy (about 57.8%)
Lepromin ; Leprosy

1. The saturated solution of starch, inulin and lactose could not inhibit the growth in media of monilia albicans. Trichophyton interdigitable and alternaria species. 2. In the cultivation findings of monilia albicans shows imperfect or dysfigured elementary pattern in saturated maltose, mannitol and ruffinose media, and was inhibited the growth by sucrose and dextrose lotion. 3. Saturated mannitol solution inhibit growth of trichophyton interdigitable strain and mannitol and dextrose inhibit the alternaria cultivation.
Alternaria ; Candida ; Fungi* ; Glucose ; Inulin ; Lactose ; Maltose ; Mannitol ; Saccharum* ; Starch ; Sucrose ; Trichophyton

The study was made in order to investigate the present status of superficial dermatomycoses and incidence and frequency of the disease, sex distribution by the statistical survey and varieties of the causative organism by the mycological observation. The survey was made by out-patients of dermatology clinic of Seoul National University, and private clinic of Inchon, Jeonjoo, Kwangjoo, Pusan and Kyonggido provinces during 3 years, from 1972 to 1974. The results are as folIows: 1. Tinea(T.) cruris shows a increase and T. capitis shows a decrease in number as compared with those of during 1959. 2. Frequency of T. cruris shows more high in citizens than in a rustics, and more high in a rustics than citizens in those of T. capitis. 3. The strains were isolated by ordinary sabouraud's glucose agar media and obtained 4 species, 58 strains. A. Trichophyton rubrum was most common organism of superficial dermatomycoses (58.6%).b. Trichophyton ferrugineum was exclusive organism of T.capitis in or country.
Agar ; Busan ; Dermatology ; Dermatomycoses* ; Glucose ; Gyeonggi-do ; Humans ; Incheon ; Incidence ; Outpatients ; Seoul ; Sex Distribution ; Trichophyton

The study was made in order to investigate the present status of superficial dermatomycoses and incidence and frequency of the disease, sex distribution by the statistical survey and varieties of the causative organism by the mycological observation. The survey was made by out-patients of dermatology clinic of Seoul National University, and private clinic of Inchon, Jeonjoo, Kwangjoo, Pusan and Kyonggido provinces during 3 years, from 1972 to 1974. The results are as folIows: 1. Tinea(T.) cruris shows a increase and T. capitis shows a decrease in number as compared with those of during 1959. 2. Frequency of T. cruris shows more high in citizens than in a rustics, and more high in a rustics than citizens in those of T. capitis. 3. The strains were isolated by ordinary sabouraud's glucose agar media and obtained 4 species, 58 strains. A. Trichophyton rubrum was most common organism of superficial dermatomycoses (58.6%).b. Trichophyton ferrugineum was exclusive organism of T.capitis in or country.
Agar ; Busan ; Dermatology ; Dermatomycoses* ; Glucose ; Gyeonggi-do ; Humans ; Incheon ; Incidence ; Outpatients ; Seoul ; Sex Distribution ; Trichophyton

It is well known that there are many kinds of strains of fungi in the atmosphcre and important problems of the relationship between these microorganisms and human bcing. The survcy vas performed to find the source of fungal infection by the determination of pathogenic fungi at the sites of much frequented travelIed, very confused perdestrian traffic, contaminated indoors of hospital huilding. For the purose of clctermining the aerial fungi collected at the selected areas in clinic of Seoul National University Haspital (out-patient roorn and corridor, kitchen room, corridor of operating room, pharmacy floor, supply room and in-patient rooms) by sampling method of gravity seilimentation by 5 minutes exposure of Sabourands glucose agar plate (5cm. diarmeter dish) and identified the fungi macroscopically and microscopicalIy. The rusults are as follows; 1. From 8 indoor ares of hospital, 441 colonies were sampled and average number of funga1 co!onies in each of the agar plate was computed to 3,675 colonies. Total generas abtained by cultivation were 9 generas, and the common fungi in air were hormodcndrurn(18. 59%), penicillium(17.68%) and aspergilIus (16.55%) in crder frequency. 3. No pathogenic fungi were isolated, and it is assumed that there is no radical problem of infection source in hospita.I indoors practicalIy.
Agar ; Fungi ; Glucose ; Gravitation ; Humans ; Operating Rooms ; Pharmacy ; Seoul

These studies were undertaken not only to evaluate the morphological change of topical vitamin A acid but also to compare the methodological difference in application, simple application and ODT, on mature mouse tail skin. All 18 animals were divided into 5 groups and serial biopsy was done after application of 0. 05% vitamine A achid and ointment base. I. 1 untreated control mouse. II. 2 mice treated with simple application of ointment base for 7 days. III. 3 mice treated with ODT of ointment base for 7 days. IV. 8 mice treated with sirnple application of 0. 05% vitamine A acid for 21 days. V. 4 mice treated with ODT of 0. 05% vitamin A acid for 7 days. The results are as follows: 1. Increase in epidermal thickness (60. 2 micron) was produced by simple applic- ation of 0. 05 % vitamin A acid for 21 days, but epidermal hypoplasia was noticert by ODT for 7 days. 2. Induction of granular layer was demonstrated by simple application of 0. 05 % vitamin A acid for 21 days. 3. There was a tendency of horny layer desquamation and epidermal darnage in application of vitamine A acid. Most severe desquamation and damage was produced by simple application of 0. 05% vitarnine A acid for 7 days. After that recovery was noticed in spite of continuous application for 21 days. 4. Epidermal hyperplasia, slight detachrnent of horny layer and epidermal damage were also produced by ODT of ointment base, probably due to nonspecific stimulation.
Animals ; Biopsy ; Hyperplasia ; Mice* ; Skin* ; Tail ; Tretinoin* ; Vitamin A* ; Vitamins*

The study was made in order to investigate the present status of superficial dermatomycoses and some changes on the frequency of the diseases, sex distribution and varieties of the causative organisms by the statistic and mycological observation. The survey was made by out-patients of Dermatology clinic of Seoul National University during 3 years, from 1967 to 1970. The results are as follows: 1. Tinea (T) capitis shows a great decrease (1/4) and T. cruris shows a increase in number as compared with those of during 1957-1960. 2. In T. capitis the number of male cases is equal to that of female cases. It is remarkable difference that the ratio of sex distinetion showed 25 males against to one female during 1967 to 1970. 3. The strains were isolated by ordinary sabouraud's glucose agar media and obtained 4 species, 125 strains. a. Tr. rubrum was most predominant organism of T. pedis & manum, T. cruris, T. corporis and Onychomycosis in Seoul districs. b. Tr. ferrugineum was most common organism of T. capitis (80%).
Agar ; Dermatology ; Dermatomycoses* ; Female ; Glucose ; Humans ; Male ; Onychomycosis ; Outpatients ; Seoul ; Sex Distribution ; Tinea

Lichen planus with herpes zoster which showed generalized hyperpigmentation, plated papular eruption, fine scale and vesicular eruption on the right thigh were reported and the literatures of lichen planus were reviewed. The case was 41 years old man, who began to have itching, erythem and fine scale 6 years ago, but had no other symptom. Histopathologically, epidermis was hyperkeratotic, acanthotic and granular layer thickening and vesicular formation.
Adult ; Epidermis ; Herpes Zoster* ; Humans ; Hyperpigmentation ; Lichen Planus ; Pruritus ; Thigh

Author reported a case of Ritters disease,, 12 days old, male, who had visited with complaining generalized skin exfoliation. This patient was suffered from erythematous papules, vesicles and bullae on entire body from 7 days ago. He was treated with antibiotics and antibiotic ointment, and was discharged.
Anti-Bacterial Agents ; Humans ; Male ; Skin ; Staphylococcal Scalded Skin Syndrome*

We studied germination activities of fungus conidiospores in active growth phase using the hanging slide culture method, then investigated the inhibitory effects of two antifungal agents(Tolnaftate and Clotrimazole) on germination activities. The fungal strains used in this study were Trichophyton (T.) rubrum, T. mentagrophytes and Candida (C.) albicans. Each strain was cultured on the Sabouraud's glueose agar plate and examined daily for detection of active growth phase of conidiospores (blastospores in C. albicans). After the conidiospores reached to active growth phase the activated spores were inoculated in one drop of Sabouraud's glucose broth on the cover glass and the hanging slide cultures were performed. The mean hermination rates of T. rubrum and T. nentagrophytes were 87.5% and 78% respectively in 72 hours. In C.albicans the average germination rate was 85.7% after cultivation for 24 hours, this germination rate was much faster than that of T.rubrum and T.mentagrophytes. For detection of miniman inhibitory concentration (MIC) of the antifungal agents to germination activities the antifungal agents were diluted with Sabouraud's glucose broth to various concentration and hanging slide culture was performed with the media containing the antifungal remedies. The minimal concentration of antifungal agents in which the conidiospores could completely not be germinated was denoted to minimal inhibitory concentration. The MIC of Tolnaftate to T.rubrum and T.mentagrophytes were 0.0.1ug/ml. The MIC of Cloirimazole to T. rubrum and T.mentagrophytes were 0.1ug/ml and to C. albicans was 1ug/ml. This results were similar to the previous reports by other investigators. This is a new method that could be applicated for evaluation of antifungal activities of antifungal agents.
Agar ; Antifungal Agents* ; Candida ; Fungi ; Germination* ; Glass ; Glucose ; Humans ; Research Personnel ; Spores ; Tolnaftate ; Trichophyton