2.Recent progress in short QT syndrome.
Kui HONG ; Hai SU ; Xiao-shu CHENG
Chinese Journal of Cardiology 2006;34(9):858-860
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Arrhythmias, Cardiac
;
diagnosis
;
genetics
;
therapy
;
Child
;
Child, Preschool
;
Electrocardiography
;
Humans
;
Infant
;
Male
;
Middle Aged
;
Syndrome
4.Effect of propofol on hypoxic pulmonary vasoconstriction in rats
Chinese Journal of Anesthesiology 1995;0(12):-
Objective To investigate the effect of propofol on hypoxic pulmonary vasoconstriction(HPV)and assess the underlying mechanism in rats.Methods Twenty male SD rats weighing 300-400 g were.anesthetizedwith intraperitoneal phenobarbital.Heart and lungs were removed after thoracotomy.Pulmonary.arterial rings 4 mmin length and 1.0-1.4 mm in diameter were prepared and suspended in Earl solution maintained at 37℃ with a pHof 7.40 and aerated with 20% O_2-5% CO_2-25% N_2.The rings were stimulated with phenylephrine(PE)10~(-6)mol?L~(-1) with different preloads(300,500,700,900,1 100 mg).The isometric tension of the arterial rings wasmeasured.The optimal preload was determined to be 900 mg which allowed best contractility.Hypoxia was inducedby aerating the solution with 95% N_2-5% CO_2 and the flow rate was adjusted to maintain PO_2 of the solution at40-20 mm Hg and pH at 7.40.HPV of the rings were recorded.Then propofol was added to achieve a finalconcentration of 1,3,10,30,100 ?mol?L~(-1) and HPV was again induced and the changes in HPV wererecorded.In addition the effects of propofol(10,30 ?mol?L~(-1))on vasoconstriction produced by KCI and PE werealso measured.Results The lower doses of propofol(10 ?mol?L~(-1))significantly inhibited HPV(P
5.Several Correlative Ethical Issues on Community-Based Healthcare Service
Song PENG ; Shu-Xia HU ; Hong DING ;
Chinese Medical Ethics 1994;0(06):-
The community - based healthcare service is a main component of healthcare service system in China,and its development is affected by several factors including correlative ethical issues.In order to maintain a long - term and stable development of community - based healthcare service,great importance should be attached to some concerned ethical issues,such as the human - oriented service,intimacy of patients,the interests of disadvantaged group,etc.
6.The immune reaction in mucosal and systemic immune system was induced after intranasal immunization with bivalent Shigella vaccines
Cuili SHU ; Jieying GAO ; Hong PENG
Chinese Journal of Immunology 2001;0(10):-
Objective:To observe the effect on different mucosal sites and system immune sites after intranasal immunization with bivalent Shigella vaccines Methods:BALB/c mice were divided into three groups at random , 10 mice per group Mice were intranasally immunized respectively with FSM 2117or FS 5416 (4?10 7CFU) three doses with an interval of two weeks The NALT, NP, spleen, PP, MLN, lymphocytes were isolated on the seventh day after the last immunization to assay the change of the cell phenotype with FACS The nasal ?lung?intestine?genital tract lavage fluid and serum were taken to assay the specific IgA or IgG against F2a or Sonni LPS with ELISA Results:The specific IgA and IgG in different mucosal sites and serum increased significantly after intranasal immunization with two Shigella vaccines compared with the control (P
7.A study of pathohistological and immunohistochemical features of 120 cases of osteosarcoma
Fengxun GAO ; Zengpeng LI ; Hong SHU
Journal of Third Military Medical University 1983;0(03):-
One hundred and twenty cases of osteosarcoma were reported.Re-examination of all the tissue specimens revealed that typical neoplastic osteoid was found only in 83% of the cases.It is now generally accepted that the demonstration of osteoid is not essential for the diagnosis,but the microscopic features of sarcomatous stroma,pheomorphism of osteoblasts,anaplastic giant cells,chondrosarcomatous and fihrosarcomatous tissue are of diagnostic importance.The differential diagnosis between neoplastid osteoid and pseudo-osteoid(fibrillar hyalin-ized collagen)were discussed.Forty-eight surgical specimens were stained with polyclonal actin,monoclonal BMP,vi-mentin,collagen type IV and UEA-1 with immunohistochemical ABC.It was found that when there was combined positive expression of monoclonal BMP,vimentin,collagen type IV,UEA-1 and polyclonal actin,or monoclonal BMP,vimentin UEA-1 and/or polyclonal actin,or monoclonal BMP,vimentin and/or polyclonal actin,it was of diagnostic value.However,the five markers were of no value to distinguish fibrillar hyalinized collagen from osteoid stroma.It is believed that the appropriate combination of the immunohistochemical markers is imperative to promote the accuracy of the pathological diagnosis of osteosarcoma and its differential diagnosis.
8.Serum Level of Three Kinds of PAEs in Children Living in City and Countryside in an Area in China
Xingbi DAI ; Weiqun SHU ; Hong DAN
Journal of Environment and Health 1989;0(06):-
Objective To understand the body burden of PAES in the children aged 10-12 years,living in city and countryside and estimate the potential hazard of PAEs for the children. Methods The reversed phase high performance liquid chromatography (RP-HPLC) was employed to determine the serum level of three kinds PAEs (DEP,DBP and DEHP) in two groups of children,including 36 city children and 38 countryside children in Jan. 2007. Results In the city children,the average serum level (median) of PAEs was 0.002 6 mg/L for DEP,0.035 9 mg/L for DBP and 0.106 25 mg/L for DEHP. In the countryside children,the serum level of PAEs was 0.000 0 mg/L for DEP,0.040 6 mg/L for DBP and 0.052 45 mg/L for DEHP. The differences of average levels of DEP and DEHP between the two groups were significant (P
9.Relationship between expression of Twist and KiSS-1 and progonosis in non-small cell lung cancer
Honglan ZHANG ; Hong SHU ; Weiguo JIANG
China Oncology 2006;0(11):-
Background and purpose:Twist has been identifi ed as tumor metastasis promoter transcription factor and KiSS-1 has been identified as tumor metastasis suppressor gene,and both of them have been identified to be associated with the metastatic potential of non-small cell lung cancer(NSCLC) .Our aim was to identify the expression of both Twist and KiSS-1 in NSCLC and analyze their correlation with patients’ survival.Methods:Immunohistochemical staining using monoclonal Twist and KiSS-1 antibody were performed on paraffi n embedded specimens from 61 patients diagnosed with NSCLC,and 15 specimens of tumor surrounding lung tissue were used as control.The association with clinicopathologic data and prognosis of NSCLC were analyzed.Results:The expression of Twist was significantly higher in NSCLC than in tumor surrounding lung tissue(P
10.A signal analysis method for bioelectrical impedance measurement of gastric motility based on HHT
Linyan CHAI ; Shu ZHAO ; Hong SHA
International Journal of Biomedical Engineering 2011;34(2):82-85
Objective The Hilbert- Huang transformation (HHT) method was introduced to process the bio-impedance gastric motility signals from subjects.Methods Nonlinear and non-stationary original gastric motility series were decomposed into a number of intrinsic mode function (1MF) components by the empirical mode decomposition method (EMD).Hilbert transformation was carried out then and instantaneous frequency was extracted effectively.Gastric motility signal among 0.03-0.06 Hz was reconstructed from the IMF.Results The results suggested that HHT was a new and applicable time series analysis method based on mode decomposition and could extract impedance signal and remove the disturbances such as blood flow and breathing.Conclusion The new adaptive mode decomposition-based signal processing method provides a new method to investigate clinical gastric motility information.