1.Mutagenic Assessment of Olmesartan Cilexetil by Bacterial Mutation Assay.
Ji Won KIM ; Ilyoung AHN ; Sung Ha RYU ; Hong Ryeol JEON ; Bong Sang LEE ; Kyu Bong KIM
Toxicological Research 2013;29(3):217-219
Hypertension is a serious health problem due to high frequency and concomitant other diseases including cardiovascular and renal dysfunction. Olmesartan cilexetil is a new antihypertensive drug associated with angiotensin II receptor antagonist. This study was conducted to evaluate the mutagenicity of olmesartan cilexetil by bacterial reverse mutation test using Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) and Escherichia coli (WP2 uvrA). At the concentrations of 0, 62, 185, 556, 1667, and 5000 microg/plate, olmesartan cilexetil was negative in both Salmonella typhimurium and Escherichia coli regardless of presence or absence of metabolic activation system (S9 mix). These results demonstrate that olmesartan cilexetil does not induce bacterial reverse mutation.
Biotransformation
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Escherichia coli
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Hypertension
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Imidazoles
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Receptors, Angiotensin
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Salmonella typhimurium
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Tetrazoles
2.A Case of Unilateral Hyperlucent Lung by Main Bronchus Obstruction.
Yong Bum CHO ; Kyeong Soo PARK ; Jeong Bae JEON ; Jeong Seon RYU ; Tae Hoon MOON ; Jae Hwa CHO ; Seung Min KWAK ; Hong Ryeol LEE ; Chul Ho CHO
Tuberculosis and Respiratory Diseases 2000;48(2):268-273
A 32-year-old woman was admitted to the hospital complaining of cough, sputum, and chest discomfort for the past ten days. The radiologic findings were transradiant left lung with reduced number and size of vessels, mediastinal shifting to the right at expiration, matched entilation-perfusion defect on ventilation-perfusion scan, and diffuse hypoplasia of the left pulmonary artery and its branches on pulmonary angiography. We describe a case of unilateral hyperlucent lung by main bronchus obstruction in a patient who presents with a clinical picture suggestive of Swyer-James syndrome.
Adult
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Angiography
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Bronchi*
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Cough
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Female
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Humans
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Lung
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Lung, Hyperlucent*
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Pulmonary Artery
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Sputum
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Thorax
3.N-Terminal Pro-B-Type Natriuretic Peptide as a Prognostic Marker in Acute Coronary Syndrome.
Kyung Kee BAEK ; Eun Seok JEON ; IL RHEE ; Sung Hea KIM ; Je Sang KIM ; Pil Sang SONG ; Dong Ryeol RYU ; Jin Ho CHOI ; Ji Dong SUNG ; Sang Chol LEE ; Seung Woo PARK ; Hyun Cheol GWON ; June Soo KIM ; Duk Kyung KIM ; Sang Hoon LEE ; Kyung Pyo HONG ; Jeong Euy PARK
Korean Circulation Journal 2004;34(11):1070-1081
BACKGROUND AND OBJECTIVES: Biochemical markers are useful for the prediction of cardiac events in patients with acute coronary syndrome (ACS). The N-terminal fragment of the BNP prohormone (NT-proBNP), which is synthesized by cardiac ventricles in response to increased wall stress, may be a prognostic marker in ACS. The relation between the NT-pro BNP levels on admission and major adverse cardiovascular events (MACEs) were assessed in a cohort of patients with ACS. SUBJECTS AND METHODS: Between October 2002 and April 2004, blood samples for the determination of NT-proBNP level were obtained on admission from 78 patients with ST-elevation myocardial infarction (STEMI), 32 with non-ST elevation MI(NSTEMI) and 66 with unstable angina (UA). Patients were followed concerning MACEs (death, MI, heart failure, stroke and revascularization) for a median of 7 months in median. RESULTS: 22 patients (13%) had events. The mean NT-proBNP level was significantly lower in the event-free survivors than in those with events (1342+/-1598 versus 6129+/-6522 pg/mL, p<0.0001). The optimal cut-off value of the NT-proBNP level using a receiver-operating-characteristic curve was 1445 pg/mL. The unadjusted risk ratio of patients with an NT-proBNP level greater than the threshold was 7.0 (95% confidence interval, 2.6 to 19.0). In a multivariate Cox regression model, including clinical background factors and other biochemical markers, the NT-proBNP level was the most powerful indicator of MACEs (risk ratio, 8.0 [95% confidence interval, 1.7 to 37.1]). The coronary angiographic Gensini score was also a predictor of prognosis in ACS (risk ratio, 3.8 [95% confidence interval, 1.0 to 14.0]). CONCLUSION: A single measurement of the NT-proBNP level on admission appears to be useful as a prognostic factor in the prediction of MACEs in patients after ACS.
Acute Coronary Syndrome*
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Angina, Unstable
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Biomarkers
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Cohort Studies
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Heart Failure
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Heart Ventricles
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Humans
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Myocardial Infarction
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Odds Ratio
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Prognosis
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Stroke
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Survivors