The flexibility of surface layer of skin is largely dependent upon the layer's water content. This, in turn, depends primarily on the quantity of water soluble hygroscopic and surface active msterials within the straturn corneum, often known as the natural moisturizing fsctors(NMF). It consist of amino acid, lactic acid, pyrrolidone carboxylic acid and inorganic salts etc.. Some of these components are greatly influenced by hydrogen ion content and ionic form of them were found to be highly hygroscopic. In this experiment, sunburn exfoliated human stratum corneum and pig epidermis separated by 2N-NaBr were used as in vitro test. These tissues were so treated to hsve each pH value (3, 5, 7, 9) and their water holding capacity and hygroscopicity were measured by gravimetric method. The results are summarized as follows : 1, Water holding capactiy of sunburn exfoliated human skin showed significant increase at pH 5 (p<0.1), 7 (p<0.01), 9 (p<0.01) compared to pH 3, and increase in pH 7 (p<0.1), 9 (p<0.05) compared to pH 5 in lactic acid. In pig epidermis, there was significant increase at pH 5 (p<0.05), 7 (p<0.01), 9 (p<0.05) cornpared to pH 3 in lactic acid. 2. Hygroscopicity of pig epidermis showed significant increase at pH 5 (p<0.05), 7 (p<0.1), 9 (p<0.05) in lactic acid and at pH 5 Epidermis ; Humans ; Hydrogen-Ion Concentration* ; Lactic Acid ; Pliability ; Protons ; Salts ; Skin* ; Sunburn ; Water ; Wettability

We have experienced a case of the more unusual form of supernumerary breast tissue which is characterized by the presence of aberrant gland tissue alone. The case was a 30-year-old female patient in puerperium with bilateral axillary masses of seven years duration. Gentle pressure over the right-sided one caused milk to exude from a skin pore. Histopathologic findings of the tumors revealed the lobules of the breast forming islands of glandular tissue.
Adult ; Breast* ; Female ; Humans ; Islands ; Milk ; Postpartum Period ; Skin

We present a case of Kyrle's disease. The pstient was a 48-year-old male who had been undergoing hemodialysis for 6 years due to chronic renal failure caused by polycystic kidney. The lesions were hyperkeratotic papules on the lower legs and abdomen witb 3 months' duration. Histopathologically, the epidermis showed central invsgination filled with heavy keratotic, partly parakeratotic plug, basophilic debris and neutrophils. There were a few premature keratinized cells below the parakeratotic plugs and complete epidermal perforation was present.
Abdomen ; Basophils ; Epidermis ; Humans ; Kidney Failure, Chronic* ; Leg ; Male ; Middle Aged ; Neutrophils ; Polycystic Kidney Diseases ; Renal Dialysis

We present a case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) in a 57-year-old male who had suffered from fever and general weakness of one month's duration. He showed generalized lymphadenopathy, hepatomegaly and purpuric maculopapules on the whole body surface. Lahoratory findings show anemia, polyclonal gammaglobulinemia and thrombocytopenia. The lymph node biopsy specimens show morphologic triad of AILD except lack of interstitial deposits of eosinophilic materials and the skin biopsy specimen shows lymphohistiocytic vasculitis. Bone marrow biopsy specimen shows similar findings in lymph node, suggesting bone marrow involvement. He have been treated with COPP chemotherapy.
Anemia ; Biopsy ; Bone Marrow ; Drug Therapy ; Eosinophils ; Fever ; Hepatomegaly ; Humans ; Immunoblastic Lymphadenopathy* ; Lymph Nodes ; Lymphatic Diseases ; Male ; Middle Aged ; Skin ; Thrombocytopenia ; Vasculitis

No abstract available.
Epidermal Growth Factor* ; Skin* ; Wound Healing* ; Wounds and Injuries*

No abstract available.
Foot* ; Polydactyly*

This study is statistical investigation on the relationship of atopic dermatitis to molluscum contagiosum. The study was included 1,215 cases of atopic dermatitis and. 354 cases with mollescum contagiosum during the period of 1974 to 1977. According to our clinical experiences it was not uncommon to develop the combined cases with atopic dermatitis and mollucum contagiosum. On the immunological point of view the association of defective cell-mediated immunity and increased susceptibility to viral and fungaI infections in some cases with atopic dermatitis has been reported by many authors. The results are as follows: 1) The order of combined diseases in atopic dermatitis was rnolluscum contagiosum (8. 9 %), impetigo (6. 8 %), contact dermatitis (5. 1%), insect bite (3. 5 %) and urticaria (2. 0 %). The highest combined rate was seen in molluscum contagiosum. (p<0. 05) 2) The order of combined diseases in molluscum contagiosum was atopic dermatitis. (30.5%), impetigo (6.0%), contact dermatitis (5.7%) and insect bite (2.4%). The highest combined rate was seen in atopic dermatitis(p<0. 01). 3) Atopic dermatitis was more frequent in male than in female(p<0. 01) but in the age group above 11, female was more prevalent(p<0. 01). There was no sex difference for developing molluscum contagiosum in all our studied cases, but the frequency was higher in male below 5 year of age(p<0. 01%) and in female above 11 year old (p<0. 01). 4) Atopic dermatitis was frequently seen in the age group below 5 year old(72. 0%), and also moIluscum contagiosum was common in the same age group(60. 5 %). There were two peaks in incidence, below 10 year old(78. O%) and the age group of 21 to 3O(12. 4%). in molluscum contagiosum. The incidence was significantly higher in woman(10. 2%) than that of man(2. 3%) in the later group. The combined cases with atopic dermatitis and molluscurn contagiosum were more frequently seen in the age group below 5(84. 3%)but no case was found in more than 15 year old. 5) Atopic dermatitis was more frequent in winter and spring (62. 7%) than in summer and autumn(37. 3%), (p<0. 01). The combined cases with atopic dermatitis and moIluscum contagiosum were most frequent in spring(85. 2 %),(p<0. 05).
Adolescent ; Child ; Dermatitis, Atopic* ; Dermatitis, Contact ; Female ; Humans ; Immunity, Cellular ; Impetigo ; Incidence ; Insect Bites and Stings ; Male ; Molluscum Contagiosum* ; Sex Characteristics ; Urticaria

Reconstruction of extensive soft tissue defects of the lower extremity, especially when complicated by open fracture and bone loss, is usually a difficult problem for the plastic surgeon. Many methods have been devised to treat these conditions Musculocutaneous flaps add a valuable surgical alternative that bring vascularized cover to the defects, and the free microvascular transfer of these flaps gives the surgeon an added dimension of versatility. The latissimus dorsi is an extremly reliable musculocutaneous flap with a long, large-caliber vascular pedicle, so that dissection of the muscle can be performed with relative ease. The size of the latissimus dorsi muscle lends itself to coverage of large defects. While these characteristics appear to make the free latissimus dorsi musculocutaneous transfer ideal in many circumstances, it has some disadvantages. At the recipient site, the flap is ofter too bulky, and donor-site closure requires skin grafts if the flap is wider than 10cm. These skin grafts on the posterior thorax seriously detract from the final appearance of the donor site. The authors have experienced 12 cases of reconstruction of extensive lower extremity soft tissue defect in which the latissimus dorsi muscle alone was transferred and covered with a split-thickness skin graft. This method improves the recipient-site contour by decreasing the bulk of the flap and it also improves the donor-site appearance. We described technical considerations in each case and the advantages of free latissimus dorsi muscle flap and skin graft for the reconstruction of extensive soft tissue defect in the lower extremity.
Fractures, Open ; Humans ; Lower Extremity ; Myocutaneous Flap ; Skin ; Superficial Back Muscles* ; Thorax ; Tissue Donors ; Transplants

Using Avidin-Biotin immunoperaxidase method, we investigate the distribution patterns of factor VIII related antigen in various areas of skin lesions of 14 granuloma pyogenicum. and in the skin lesions of 5 capillary hemangioma and 5 normal skin. The results are summarized as follows: 1. Factor VIII related antigen was detected in 9 of 14 cases of granuloma pyogenicum, in 4 of 5 cases of capillary hemangioma, and in 5 of 5 cases of normal skin. 2. In the lesions of granuloma pyogenicum the areas with prominent capillary endothelial cell proliferation had less positivity than the vascular areas. And the areas with relatively large vesels in the lesions of granuloma pyogenicum had similar positivity as capillary hemangioma. 3. The lesions of granuloma pyogenicum and capillary hemangioma had less positivity than the vessels of normal derrnis.
Endothelial Cells ; Factor VIII* ; Granuloma* ; Granuloma, Pyogenic* ; Hemangioma, Capillary ; Skin ; von Willebrand Factor*

The use of a cultured autologous keratinocyte sheet has become a recognized method for the coverage of extensive bums during recent years. The disadvantages of these sheet grafts are a long time-lag until keratinocyte sheets are available, the fragility and difficulty in handling of grafts, an unpredictable take rate and extremely high costs. In this study we investigated the transplantation of cultured keratinocytes as single cells suspended in autologous fibrin glue. In a rat model with standardized full thickness wounds, this new transplantation technique was evaluated and compared directly to the conventional keratinocyte sheet grafting technique. After transplantation, wounds were evaluated for the degree of epithelial coverage, and then microscopic structures were evaluated under light and electron microscopy. The results were as follows: 1) The fibrinogen solution prepared from autologous blood had 12 times more fibrinogen compared to the original blood. 2) After transplantation of cultured keratinocyt-es in fibrin glue, the degree of epithelial coverage was 79% at 2 weeks, which was comparable to 17% for cultured keratinocyte sheet graft 3) Typical basement membrane structures were consistently found at 2 weeks after transplantation of keratinocytes in fibrin glue. 4) Rete ridges were found at 4 weeks after transplantation of keratinocytes in fibrin glue. In conclusion, the transplantation technique of keratinocytes in fibrin glue is available earlier than sheet grafts, it transfers actively proliferating cells and it simplifies the grafting procedure. As well, this technique leads to an earlier epithelial covering and an earlier restoration of the dermo-epidermal junction than sheet grafting.
Basement Membrane ; Fibrin Tissue Adhesive* ; Fibrin* ; Fibrinogen ; Keratinocytes* ; Microscopy, Electron ; Models, Animal ; Transplants ; Wounds and Injuries