No abstract available.
Child* ; Coronary Vessels* ; Heart Diseases* ; Heart* ; Humans ; Infant*

No abstract available.
Aorta* ; Blood Flow Velocity* ; Child* ; Echocardiography, Doppler* ; Humans ; Pulmonary Artery*

MicroRNA,which is found in recent years,is a class of small noncoding RNAs of about 18-24 nucleotides in length,that can regulate gene expression.It induces mRNA degradation or inhibit translation of tagert genes mainly by complete or incomplete base pairing to the 3' untranslated region of tagert messenger RNAs.The application of microRNA biology technology provides new methods to the research of multiple diseases,and can further elucidate its occurrence,development mechanism.In this paper,microRNA biology-related researches are introduced and miR-125 in a variety of diseases is reviewed.

No Abstract available.

BACKGROUND: Biphasic or triphasic or quadriphasic pattern of pulmonary venous flow has been described by color Doppler echocardiography in normal subjects. Absolute velocity measurements varied with the position of the probe in relation to the pulmonary vein. The purpose of this study is to evaluate the normal pulmonary venous flow pattern and compare the data according to age, body weight, height and body surface area. METHODS: 244 normal children underwent transthoracic echocardiography from December 1992 to July 1993. Age ranged from newborns to 13 years. From the apical four chamber view, pulmonary venous flow velocity and integral were obtained. RESULTS: Quadriphasic pulmonary flow pattern(early systolic flow, late systolic flow, diastolic flow, atrial reversal flow) was identified. Pulmonary venous peak flow velocity was not different according to increasement of age, body weight, height or body surface area. But pulmonic flow integral was significantly increased according as increasement of age, body weight, height, or body surface area. CONCLUSION: Transthoracic color Doppler echocardiography is a good noninvasive diagnostic tool to evaluate pulmonary venous flow pattern in children.
Body Surface Area ; Body Weight ; Child ; Echocardiography ; Echocardiography, Doppler, Color* ; Humans ; Infant, Newborn ; Pulmonary Veins

Color Doppler echocardiography was performed to evaluate pulmonary venous flow pattern at 1st~2nd day of birth in 84 fullterm newborns (36: patent ductus arteiosus, 48: closed ductus arteriosus). Aortic and pulmonic diameter, velocity and integral were estimated. The purpose of this study ascertained that patent ductus arteriousus changed the pulmonary vein velocity and flow integral. The results were as follows. 1) There was no significant difference in aortic diameter and peak velocity, but significant difference in flow integral before and after closure of ductus arteriosus. 2) There was no significant difference in pulmonic velocity and flow integral, but significant difference in diameter before and after closure of ductus arteriosus. 3) Early systolic flow velocity, late systolic flow velocity, diastolic flow velocity in pulmonary vein were higher in patent ductus arteriosus group at 1st~2nd day, but atrial reversal flow velocity was not significantly different. 4) Diastolic pulmonary venous flow integral was higher in patent ductus arteriosus group at 1st~2nd day. Thus four distinct phases(early systolic wave, late systolic wave, diastolic wave, and atrial reversal wave) were identified before and after closure of ductus arteriosus. Left to right shunt via ductus arteriosus increased systolic, diastolic pulmonic venous velocity and diastolic flow integral. We will investigate pulmonary venous flow patterns in other left to right congenital heart diseases or mitral regurgitation.
Ductus Arteriosus* ; Ductus Arteriosus, Patent ; Echocardiography, Doppler* ; Echocardiography, Doppler, Color ; Heart Diseases ; Humans ; Infant, Newborn* ; Mitral Valve Insufficiency ; Parturition ; Pulmonary Veins

Objective: To observe changes of EEG parameters,including bispectral index (BIS),spectral edge frequency(SEF)and median frequency(MF),and the association between the changes of EEG variables and hemodynamic responses to intubation during induction by propofol with or without fentanyl. Method: Twenty-four ASA grade Ⅰ-Ⅱ patients were randomly assigned to double-blindly receiving intravenous propofol/normal saline (group P, n=12)or propofol/fentanyl 2?g/kg(group PF,n=12), respectively. Intubation was performed following 5-min maintenance of BIS within 45?5. EEG and hemodynamic variables were recorded at endpoints of pre-induction, pre-intubation and post-intubation. Result:In group P,blood pressure and heart rate at post-intubation were significantly increased compared with pre-induction value(P

No abstract available.
Erythroblastosis, Fetal* ; Gene Frequency* ; Infant, Newborn

PURPOSE: This study was to examine the effects of supportive nursing care on surgical patients in the operating room. METHOD: This study was nonequivalent control group none-synchronized design. The data were collected during the period of July 26 through October 8, 1999 at K hospital in Kwangju. The subjects for the study were selected from those patients who were admitted to K hospital for abdominal surgery. Forty-eight adult subjects were selected and evenly divided into two groups: 24 for the experimental group and the other 24 for the control group, respectively. The tool used for measuring state and trait anxiety was the one originally worked out by Spilberger(1976), and translated by Kim Jung-Taek and Shin Dong-Kyun(1978) for suitable application for Koreans. Data were analyzed by x2-test, t-test, Chronbach's alpha coefficient using SAS/PC+. RESULT: Results were as follows: 1. The degree of State anxiety was found to be lower in the experimental group who received supportive nursing care in the operating room immediately before an operation than the control group who did not."(p<.001). 2.There was no significant difference on the post-test blood pressure and pulse rate immediately before operation between the two groups(p>.05). CONCLUSION: Results of the above study reveals that the supportive nursing care in the operating room is effective in alleviating the anxiety of patients. I suggest that it is highly desirable to apply supportive nursing care for those patients who are waiting for immediate surgery.
Adult ; Anxiety* ; Blood Pressure ; Gwangju ; Heart Rate ; Humans ; Nursing Care* ; Nursing* ; Operating Rooms*

Objective To understand the correlation between insulin resistance(IR) and adrenal androgen excess in adolescents with polycystic ovary syndrome (PCOS). Methods According to BMI, 90 adolescents with PCOS were divided to groups of normal weight PCOS(NW-PCOS,33 cases,BMI<25.0 kg/m2) and obesity PCOS(OB-PCOS,57 cases, BMI≥ 25.0 kg/m2),and 15 normal weight healthy girls matched for age as controls.All patients had normal OGTT.Acute ACTH stimulating test was performed on patients, and cortisol (F), 17-hydroxyprogesterone(17-OHP), dehydroepiandrosterone(DHEA) during ACTH testing at 0 and 60 minute (steroid0 and steroid60) were determined. Results Compared with controls, NW-and OB-PCOS patients showed significantly greater levels of total testosterone (T), Luteotropic hormone(LH), FIns, 2 hIns, and HOMA-IR(P<0.01).The freqnencies of hirsuties and acne, and serum level of FIns, 2 hIns, and HOMA-IR were significantly higher and LH levels were much lower in the group of OB-PCOS than those in NW-PCOS(P<0.05 and P<0.01).ACTH stimulating test showed that PCOS patients had significantly higher levels of basal 17-OHP0, DHEA0, as well as 60-minute ACTH-stimulated levels (Steroid60) of 17-OHP60、DHEA60, and net increase of 17-OHP(Δ17-OHP)as compared with normal controls(P<0.05 and P<0.01).The 60-minute ACTH-stimulated levels of 17-OHP60, DHEA60,Δ17-OHP, and ΔDHEA were also higher in group of OB-PCOS than those in group of NW-PCOS(P<0.05 and P<0.01), and there were no obvious discrepancies in basal 17-OHP0, DHEA0 between OB-PCOS and NW-PCOS groups.Spearman correlation analysis showed that in group of OB-PCOS, HOMA-IR value was significantly associated with BMI, 17-OHP60, Δ17-OHP, DHEA60, ΔDHEA(P<0.05 and P<0.01); whereas in group of NW-PCOS, HOMA-IR was associated only with BMI(P<0.01). Conclusions The significantly higher basal and ACTH-stimulated levels of 17-OHP and DHEA indicates adrenal hyperresponsiveness in adolescents with PCOS.Adrenal androgen excess appears to be closely associated with insulin resistance in obese adolescents with PCOS