Lipodystrophia centrifugalis abdominalis infantilis, an typical form of progressive lipodystrophy, is a disease mainly decribed in japanese infants. We report a case of lipodystrophia centrifugalis abdominals infantilis in Korean infant. The patient is a 2 year-old-girl with a coin sized well defined depressed lesion with surrounding redness and scaly changes in the right inguinal region. The skin from the depressed lesion revealed changes similar to those originally described by Imamura et al.
Infant ; Male ; Female ; Humans

No abstract available.
Compliance* ; Humans

No abstract available.
Compliance* ; Humans

Primary hepatic sarcoma is a rare tumor, with fewer than 60 previously reported cases. It is thought to arise from hepatic connective tissue or vascular channels. The tumor is located usually in the intrahepatic area. Pedunculated or bulging lesion is also reported. We report a case of primary leiomyosarcoma of the liver occuring in a 62-year-old Korean woman. A pedunculated, 21 16 cm sized mass is located in the left lateral segment of the liver. Microscopically, the tumor is hypercellular and composed of elongated, partly pleomorphic spindle cells with blunt-ended nuclei, which are focally reactive for muscle specific actin. Mitotic figures are 5/10 high power fields (HPFs). No other primary site is recognized on clinical study.
Actins ; Connective Tissue ; Female ; Humans ; Leiomyosarcoma* ; Liver ; Middle Aged ; Sarcoma

Of 375 newborn infants in Korea General Hospital in the period of 6 months from March 1 to August 30, 1976. 304 newborn infants were available for the study of serum bilirubin level at the third day of the birth. The followings are results analyzed: 1) The mean value of serum bilirubin level estimated is 10.6mg%. The incidence of neonatal jaundice is estimated as 95.4 percent. 2) The premature infants reveal a marked elevation of serum bilirubin level. Conditions with increased level of serum bilirubin in variable degree include vacuum suction and/or forcep delivery, high or low hematocrit value, low Apgar scores, artificial resuscitation, cephalhematoma and spontaneous premature rupture of the membrance. 3) No relationship in serum bilirubin levels between differences in sex, body weight, number of pregnacies and ABO blood groups of mother and infant is present in this study.
Bilirubin ; Blood Group Antigens ; Body Weight ; Hematocrit ; Hospitals, General ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Premature ; Jaundice, Neonatal* ; Korea ; Mothers ; Parturition ; Resuscitation ; Rupture ; Suction ; Surgical Instruments ; Vacuum

Dyschromatosis universalis hereditaria is a rare pigmentary disorder initially described in the Japanese literature. The pattern of inheritance is believed to be autosomal dominant, but many sporadic cases have been reported. We encountered a family in which dyschromatosis universalis hereditaria occurred in seventeen members of three generations. In the two members whom we observed, typical skin lesions were distributed all over the body except palrns and soles. By pedigree analysis, we found an autosomal dominant pattern of inheritance. The differential diagnosis of the other reticulate pigmentary disorders is discussed with a review of dyschromatosis reported in the Korean literature.
Asian Continental Ancestry Group ; Diagnosis, Differential ; Family Characteristics ; Humans ; Pedigree ; Skin ; Wills

Diabetes Mellitus (DM) is a syndrome accompanied with the abnormal secretion or function of insulin, a hormone that plays a vital role in controlling the blood glucose level (BGL). Type 1and 2 DM are most common form and the prevalence of the latter is recently increasing. The aim of this article was to assess whether Type 2 DM could act as a predisposing risk factor on the pulpo-periapical pathogenesis. Previous literature on the pathologic changes of blood vessels in DM was thoroughly reviewed. Furthermore, a histopathologic analysis of artificially-induced periapical specimens obtained from Type 2 diabetic and DM-resistant rats was compared. Histopathologic results demonstrate that the size of periapical bone destruction was larger and the degree of pulpal inflammation was more severe in diabetic rats, indicating that Type 2 DM itself can be a predisposing risk factor that makes the host more susceptible to pulpal infection. The possible reasons may be that in diabetic state the lumen of pulpal blood vessels are thickened by atheromatous deposits, and microcirculation is hindered. The function of polymorphonuclear leukocyte is also impaired and the migration of immune cells is blocked, leading to increased chance of pulpal infection. Also, lack of collateral circulation of pulpal blood vessels makes the pulp more susceptible to infection. These decrease the regeneration capacity of pulpal cells or tissues, delaying the healing process. Therefore, when restorative treatment is needed in Type 2 DM patients, dentists should minimize irritation to the pulpal tissue un der control of BGL.
Animals ; Blood Glucose ; Blood Vessels ; Collateral Circulation ; Dentists ; Diabetes Mellitus ; Humans ; Inflammation ; Insulin ; Microcirculation ; Neutrophils ; Prevalence ; Rats ; Regeneration ; Risk Factors ; United Nations

Lichens have been known to possess multiple biological activities, including anti-proliferative and anti-inflammatory activities. Vascular cell adhesion molecule-1 (VCAM-1) may play a role in the development of atherosclerosis. Hence, VCAM-1 is a possible therapeutic target in the treatment of the inflammatory disease. However, the effect of lobaric acid on VCAM-1 has not yet been investigated and characterized. For this study, we examined the effect of lobaric acid on the inhibition of VCAM-1 in tumor necrosis factor-alpha (TNF-alpha)-stimulated mouse vascular smooth muscle cells. Western blot and ELISA showed that the increased expression of VCAM-1 by TNF-alpha was significantly suppressed by the pre-treatment of lobaric acid (0.1-10 mug/ml) for 2 h. Lobaric acid abrogated TNF-alpha-induced NF-kappaB activity through preventing the degradation of IkappaB and phosphorylation of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), and p38 mitogen activated protein (MAP) kinase. Lobaric acid also inhibited the expression of TNF-alpha receptor 1 (TNF-R1). Overall, our results suggest that lobaric acid inhibited VCAM-1 expression through the inhibition of p38, ERK, JNK and NF-kappaB signaling pathways, and downregulation of TNF-R1 expression. Therefore, it is implicated that lobaric acid may suppress inflammation by altering the physiology of the atherosclerotic lesion.
Animals ; Atherosclerosis ; Blotting, Western ; Down-Regulation ; Enzyme-Linked Immunosorbent Assay ; Extracellular Signal-Regulated MAP Kinases ; Inflammation ; Lichens ; Mice ; Muscle, Smooth, Vascular* ; NF-kappa B* ; Phosphorylation ; Phosphotransferases ; Physiology ; Tumor Necrosis Factor-alpha ; Vascular Cell Adhesion Molecule-1*

Ovarian remnant syndrome is a rare condition which develops when functional ovarian tissue is left in situ after intended bilateral oophorectomy. It produces clinically significant syndrome, namely chronic pelvic pain and dysmenorrhea. Although the true incidence of this syndrome is unknown, an apprant increase in incidence has been reported. We have experienced a case of ovarian remnant syndrome showing chronic pelvic pain and palpable abdominal mass after difficult gynecologic operation. So, we report this case with a brief review of literatures.
Dysmenorrhea ; Female ; Incidence ; Ovariectomy ; Pelvic Pain

Traumatic pseudoaneurysms of the cavernous portion of the internal carotid artery(ICA) presenting with epistaxis are uncommon and potentially lethal complication of head injury. Because the onset of delayed bleeding from the time of injury is variable, prompt diagnosis and treatment of cavernous ICA pseudoaneurysm is important. A patient with a giant traumatic pseudoaneurysm of the left ICA presented with massive epistaxis 5 months after a head trauma. This patient was treated with occlusion of the opening of pseudoaneurysm and ICA by a detachable balloon and fibered coils.
Aneurysm, False* ; Balloon Occlusion ; Carotid Artery, Internal* ; Craniocerebral Trauma ; Diagnosis ; Epistaxis ; Hemorrhage ; Humans