No abstract available.
Caloric Tests*

We describe herein four cases of childhood dermatomysitis of Brunsting type. The ages of these patients were between 7 to 10 years at the time of the disease. All four patients had pathognomOnic cutaneous changes, such as heliotrope erythema and Gottron's papules, which are not seen frequently in adult type dermatomyositis. These patients did not show any marked serologic abnormalities suggestive of having other connective tissue diseases or autoimmune diseases. All patients were initially treated with prednisolone and chloroquine, and have been under control with low dose prednisolone, or chloroquine alone.
Autoimmune Diseases ; Chloroquine ; Connective Tissue Diseases ; Dermatomyositis* ; Erythema ; Humans ; Prednisolone

158 cases of pulmonary metastasis having satisfactory histological proof of the primary malignant tumor, the frequency and pattern of which were analysed by conventional radiologically. The results are as follows: 1. The frequency of pulomonary metastasis according to the primary sites was 24%(38/158) hepatobiliary system,19.6%(31/158) gastrointestinal tract, 18.9%(30/158) uterine cervix and 12%(13/158) head and neck. 2. Pulmonary metastatic pattern showed nodular type 74% (117/158), granular type 10.1%(16/158), streaky type 9.5%(15/158),hilar enlargement 3.8%(6/158), patchy type 1.9% (3/158) and others 0.6%(1/158). Of all these type, nodular type was predominant. 3. The nodular type of pulmonary metastasis was classified into less than 10 nodules56.4%(66/17), 10-50 nodules 25.6%(30/117), more than 50, 17.9%(21/117), less than 1cm 12.8%(15/117) and more than5cm in 5.2%(1/117) of the cases. 4. The size of nodule was 1-3cm 36.6%(43/117), 2-3cm 20.5%(24/117), less than 1cm12.8%(15/117) and more than 5cm in 5.2%(1/117) of the cases. 5. Most cases of pulmonary metastasis involved bothlung fields 69.2%(110/58). Others were right lung field only 17.7% (28/158), left lung only 12.7%(20/158). 6. Theages between 40 and 70 represented 79.8%(126/158) of the cases and the raio of male and female was about 1.5:1.
Cervix Uteri ; Female ; Gastrointestinal Tract ; Head ; Humans ; Lung ; Male ; Neck ; Neoplasm Metastasis

No abstract available.
Scleroderma, Localized

We report a case of multiple leatiginea syndrome in an 8 year old boy. He had numeroua lentigines acattered over his face, trunk, buttock and thlghe, and eome larger black macular leeians on the trunk and thighs. Gn phyaiaal examinatlon, he wae well developed but he had ocular hyperteloriem. Chest roentgenogram showed hypertrophy of both ventricles. Electrocardiogram and audiogram revealed conduction defects and severe sensorineural deafness, reepectively. Blopsy af dark brown lesion from the back showed the histopathologlc pattern of lentigo.
Buttocks ; Child ; Deafness ; Electrocardiography ; Humans ; Hypertrophy ; Lentigo ; LEOPARD Syndrome* ; Male ; Thigh ; Thorax

Eight men with a one-ta-seven-year history of rosacea which poorly controlled by oral tetracycline or metronidazole, with or without topical medications, were given 13-cis-retinoic acid in dosages of p.5 to 0. 7 mg/kg/day for eight weeks. The size of erytherna and the number of papules had been gradually decreased since the second week of treatment. Eight weeks later more than 75p, regression was recognized in six patients, however telangiectasia remained unchanged. All eight patients complained of only mild degrees of cheilitis and dryness of the nose, and had no evidence of the serologic abnormalities on the tests examined during the period of therapy.
Cheilitis ; Humans ; Isotretinoin ; Male ; Metronidazole ; Nose ; Rosacea* ; Telangiectasis ; Tetracycline ; Tretinoin*

Biopsy specimens taken from the active lesional skin of five patients with fixed drug eruption were studied to examine the deposit of immunoreactants and to characterize the cells infiltrated in the tissue. The direct immunofluorescence showed the deposition of cytoid bodies and fibrin around the dermoepidermal interface in all five pztients, A deposition of IgG in the intercellular space of epidermis was also noted in one patient, however the intensity of fluorescence was not strong. The indirect immunoperoxidase staining using monoclonal antibodies showed that about ppg, of dermal infiltrates reacted with anti-pan-T cell(OKT11), and the ratio of OKT4a reactive clls to OKT8A reactive cells among the desmal infiltrates was approximately 1: 1. OKT.8A reactive cytotoxic T cells were found not only in the dermis but also in the dermoepidermal interface and occasionally in the epidermis. The fact that most(over 80%) of the dermal infiltrat,es were reactive with aint-HLA-DR antibodies, suggests that the T cell mediated cellular immune mechanism could be involved in large extent in the pathogenesis of fixed drug eruption.
Antibodies ; Antibodies, Monoclonal ; Biopsy ; Dermis ; Drug Eruptions* ; Epidermis ; Extracellular Space ; Fibrin ; Fluorescence ; Fluorescent Antibody Technique, Direct ; Humans ; Immunoglobulin G ; Skin ; T-Lymphocytes

PURPOSE: Keratomileusis was performed in rabbits to investigate the effects of corneal epithelium on the corneal stromal keratocyte apoptosis and the effect of human IL-1alpha and TNFalpha on apoptotic genes in human corneal stromal cells was evaluated. METHODS: Fifty six New Zealand white rabbits underwent corneal flap procedure and corneal epithelium was inserted between the corneal flap and underlying stroma. Keratocyte apoptosis was detected with the TUNEL assay. Gene array technique was used to evaluate changes in apoptosis gene in human stromal fibroblasts in response to human recombinant IL-1alpha and TNFalpha in vitro. RESULTS: Keratocyte apoptosis was significantly greater in group for flap with insertion of peripheral epithelium at 4 hours after surgery(p=0.0249). IL-1alpha or TNFalpha regulated the expression of several genes (insulin like growth factor, stress activated protein kinase, GTP binding protein, IGFBP4) up and down in human stromal fibroblasts in culture. CONCLUSIONS: We think that the differences in the stromal cell apoptosis after keratomileusis were due to stromal cell response to various factors of inserted corneal epithelium. We found various new apoptosis gene expression in cultured human keratocytes mediated by IL-1alpha and TNFalpha that were secreted in corneal epithelium. These genes likely trigger the apoptosis of keratocyte following epithelial insertion associated with corneal surgery.
Apoptosis* ; Epithelium ; Epithelium, Corneal* ; Fibroblasts ; Gene Expression ; GTP-Binding Proteins ; Humans ; In Situ Nick-End Labeling ; Keratomileusis, Laser In Situ ; Protein Kinases ; Rabbits ; Stromal Cells ; Tumor Necrosis Factor-alpha

Bezoyl peroxide, a powerful oxidizing agent, has been uaed topically in the treatment of acne vulgaris as a cream or lotion and has been shown to he effective for this codition. In 1972 Fulton emphaaized the importance of the vehicles used to obtain. maximum potential of benzoyl peroxide and for this, the gel formulation has been examined in many clinical trials. The present study was undertaken to evaluate the therapeutic effect of Fanoxyl 2.5, a 2.5% . benzayl peraxide gel, in patients with acne vulgaris. A total of 31 patients entered this study at the Departrnent of Dermatology, Jeoul National University Hospital rluring 3 rnanths period, from Decemher, 1978 through February, 1979, All patienta were instructed to apply Fanoxyl 2.5' on their affected areas once or twice a day and the nurnber of lesions on two or three t fixed areas were counted before and onee weekly after initation of the treatment. The reaults observed in the 3I patients were as follaws; 1. The percentage decrease in total nurnber of lesions in 4 weeks after treatment was 56.9%. 2. The authors could follow up for 6 weeks in 6 cases. In 6 case, the mean percentage in total number of lesions in 6 weeks after treatment was 81.7%. 3. Clesed and open eomedones were gradually eliminated; and their numbers were decreased in 4 weeks after treatment by 46.5% and 56.8% respeetiveIy. The papules were rapidly eliminated and their numbers were decreased in 4 weeka, after treatment by 79.8%. 4. Although most patients felt a mild burning sensation and tightness at the begining of the treatment, only a minority of the patients complained of discomfort due to pain(l case), erytherna(l case), tightness(2 cases),burning sensation (1 case), scaling(1 case). But all were tolerable without taking any specific measures or discontinuance of application. In one case, contact dermatitis developed after 4 weeks treatment. The authors concluded through this experiment that Panoxyl 2.5' (2.5% benzoyl peroxide gel) is a very effective local therapeutic agent in the treatment of acne vulgaris patients.
Acne Vulgaris* ; Benzoyl Peroxide* ; Burns ; Dermatitis, Contact ; Dermatology ; Follow-Up Studies ; Humans ; Sensation

No abstract available.
Hernia* ; Pneumoperitoneum*