A case report of a 6p-year-old man with crokeratosis verruciformis on the dorsa of hands & forearms is presented. This case is unusual in that the patient had late onset of the lesions and lack of a family history of the condition. Literatures are reviewed and possible linkage with Darier's disease is discussed.
Darier Disease* ; Forearm ; Hand ; Humans

This study was to investigate the relationship between the causative strains and lesional sites and to detect the status of cell mediated immunity in the patients with concurrent fungal infections. The authors performed mycological and immunologic studies on 32 patients with concurrent fungal infections who had visited the dermatologic clinic of Soonchunhyang University HospitaI from July 1982 to June 1983. The results were summarized as follows: It was 18 cases that had the positive cultures in all the lesion sites. Among them 12 cases obtained the same causative strains in all lesions of each patierit. The cultured dermatophytes were Trichophyton rubrum, 10 stains, Trichophyton mentagrophytes, 2 strains. 2. Positive inrnediate hypersitivity reaction was observed only in patients with concurrent fungal infection by trichophytin (87. 5%). 3. For the delayed hypersensitivity reaction, the mean skin reaction scores to PPD, candidin, trichophtin were l. 58, 2. 78, 0. 66 respectively in 32 patients with concurrent fungal infection and 1. 89, 2. 47, l. 50 respectively in 17 controls, but the statistically significancies were only in trichophytin (p<0. 05). 4. The mean percentage of total and active T cell counts in peripheraJ blood were 55. 2%, 23. 9% respectively in 18patients, and 64,0%, 29. 8% in controls(p<0. 05). There was a significant decrease of T-cell count in patients with concurrent fungal infections.
Arthrodermataceae ; Cell Count ; Coloring Agents ; Humans ; Hypersensitivity, Delayed ; Immunity, Cellular ; Skin ; T-Lymphocytes ; Trichophytin ; Trichophyton

A 26-year-old Korean woman had a 5 month history of pruritic, keratotic papules on the scalp, trunk, and pubic area, which were accompanied by diffuse hair loss from the scalp, eyebrows and pubic area. She also had flat-topped violaceous papules on the scalp and pubic area, and white lace-like striae on the oral mucous and hard palate. Histopathologic study of the progressive stages of the disease revealed dilated follicles filled with horny material, hyperkeratosis, hypergranulosis and hydropic degeneration of the basal cell layer. Throughout the entire subepidermal region, there was an intense bandlike infiltration of mononuclear cells, which were most prominent at the lower pole of the hair follicles. The late stage of the disorder showed atrophy of the epidermis and atrophy of the hair follicles with fibrotic tracts, and mild mononuclear infiltrate at the sites of the former hair follicles. This is the first recorded case, to the best of cur knowledge, in Korea.
Adult ; Atrophy ; Epidermis ; Eyebrows ; Female ; Hair ; Hair Follicle ; Humans ; Korea ; Lichens* ; Palate, Hard ; Scalp

Cutaneous leishmaniasis is a self-limited infection of the skin caused by Leishmania tropica, a protozoan parasite transmitted by Phlebotomus sandfly. This disease is endemic in tropical and subtropical zone, but recently many cases of cutaneous leishmaniasis were reported in Korean among the peoples who had been worked in the Middle East. We experienced five cases of cutaneous leishmaniasis developed in Korean who had been worked in Saudi Arabia and Jordan. Skin lesions of various sized, central ulcerated and marginal elevated, with serosanguinous discharge and some crust were scattered on exposed area, especially both extremities. Histopathologic findings showed hyperkeratosis, acanthosis, pseudoepitheliomatous hyperplasia, dermal infiltration of histiocytes, lymphocytes, plasma cells and neutrophils, and numerous Leishman-Donovan bodies in and around histiocytes. About 1-4 months treatment with trimethoprim-sulfamethoxazole and metronidazole, two cases were healed with hyperpigmented scar and two cases were improved but one case was not responded.
Cicatrix ; Extremities ; Histiocytes ; Hyperplasia ; Jordan ; Leishmania tropica ; Leishmaniasis, Cutaneous* ; Lymphocytes ; Metronidazole ; Middle East ; Neutrophils ; Parasites ; Phlebotomus ; Plasma Cells ; Psychodidae ; Saudi Arabia ; Skin ; Trimethoprim, Sulfamethoxazole Drug Combination ; Ulcer

The flexibility of surface layer of skin is largely dependent upon the layer's water content. This, in turn, depends primarily on the quantity of water soluble hygroscopic and surface active msterials within the straturn corneum, often known as the natural moisturizing fsctors(NMF). It consist of amino acid, lactic acid, pyrrolidone carboxylic acid and inorganic salts etc.. Some of these components are greatly influenced by hydrogen ion content and ionic form of them were found to be highly hygroscopic. In this experiment, sunburn exfoliated human stratum corneum and pig epidermis separated by 2N-NaBr were used as in vitro test. These tissues were so treated to hsve each pH value (3, 5, 7, 9) and their water holding capacity and hygroscopicity were measured by gravimetric method. The results are summarized as follows : 1, Water holding capactiy of sunburn exfoliated human skin showed significant increase at pH 5 (p<0.1), 7 (p<0.01), 9 (p<0.01) compared to pH 3, and increase in pH 7 (p<0.1), 9 (p<0.05) compared to pH 5 in lactic acid. In pig epidermis, there was significant increase at pH 5 (p<0.05), 7 (p<0.01), 9 (p<0.05) cornpared to pH 3 in lactic acid. 2. Hygroscopicity of pig epidermis showed significant increase at pH 5 (p<0.05), 7 (p<0.1), 9 (p<0.05) in lactic acid and at pH 5 Epidermis ; Humans ; Hydrogen-Ion Concentration* ; Lactic Acid ; Pliability ; Protons ; Salts ; Skin* ; Sunburn ; Water ; Wettability

We have experienced a case of the more unusual form of supernumerary breast tissue which is characterized by the presence of aberrant gland tissue alone. The case was a 30-year-old female patient in puerperium with bilateral axillary masses of seven years duration. Gentle pressure over the right-sided one caused milk to exude from a skin pore. Histopathologic findings of the tumors revealed the lobules of the breast forming islands of glandular tissue.
Adult ; Breast* ; Female ; Humans ; Islands ; Milk ; Postpartum Period ; Skin

Lichen planus is rare in Korea and localized lichen planus on the lip without other skin lesions is even rarer. A 77-year-old man has oozing and crusting patches und somewhat ulceration surrounded by whitish reticular elements on violaceous base on both lips with burning sensation and pain. A 63-year-old man has well demarcated violaceous white reticular patches on the lower lip, buccal mucosa, glans penis and coronal sulcus. Clinical and histopathological studies of two cases showed typical features of lichen planus. They were treated with systemic and topical corticosteroids and showed much improvement.
Adrenal Cortex Hormones ; Aged ; Burns ; Humans ; Korea ; Lichen Planus* ; Lichens* ; Lip* ; Male ; Middle Aged ; Mouth Mucosa ; Penis ; Sensation ; Skin ; Ulcer

The incidence of pediatric dermatoses shows a tendency to increase inspite of medical development and environmental improvement. Pediatric dermatoses must be regarded as separate disease entities because child skin differs from adult skin in its structures and functions. Also to be noted are the special, characteristics of the child skin during the growth period. 11,447 childhood patients who had visited the demantologic department of Soon Chun Hyang Hospital, from 1975 to 1980, were analysed. in order to compile the current statistics on the tendencies of pediatric skin dises in Korea. The results are summarized as follows; l. Among the 34, 472 outpatients, 11, 447 were pediatric patients, comprising 33. 2% of the total figure. 2. In order of frequency, the most common dermatoses were atopic dermatitis, contact dermatitis, impetigo contagiosum, molluscum contagiosum, dermatophytosis, scabies, folliculitis, urticaria, varicella and insect bite. 3. The majority of childhood derrnatitis(65.5%) were shown to develop in the preschool age group, with the peak incidence falling in the 0-3 year age group (41.4%) 4. In analysis of the male: female frequency ratio, the dermatoses which showed a greater male frequency ratio were atopic dermatitis, contact dermatitis, impetigo contagiosum, scabies, insect bite, urticaria and miliaria. The dermatoses in which the female ratio was greater were seborrheic dermatitis, acne and hemangioma.
Acne Vulgaris ; Adult ; Chickenpox ; Child ; Dermatitis, Atopic ; Dermatitis, Contact ; Dermatitis, Seborrheic ; Female ; Folliculitis ; Hemangioma ; Humans ; Impetigo ; Incidence ; Insect Bites and Stings ; Korea ; Male ; Miliaria ; Molluscum Contagiosum ; Outpatients ; Scabies ; Skin ; Skin Diseases* ; Statistics as Topic* ; Tinea ; Urticaria

In adrenal insufficiency, recognition of the disease in its earlier phases may present a real challenge. The disease, if unrecognized and untreated, carries an almost uniformly poor and frequently fatal prognosis. We report a rare case of congenital adrenal aplasia accompanied by hyperpigmentation on the whole body surface. The diagnosis was confirmed by ACTH stimulation test and autopsy findings.
Adrenal Insufficiency ; Adrenocorticotropic Hormone ; Autopsy ; Diagnosis ; Hyperpigmentation* ; Prognosis

We experienced a case of Reiter's syndrome. A 20-year-old Korean male patient of Reiter's syndrome was reported. He had been suffered from mucopurulent urethral discharge, followed by white scaly patches on the skin, fever, transient conjunctivitis and arthralgia. Initially he was treated with sodium salicylic acid (Aspirin), indomethacin 150 mg/day for arthralgia and prednisolone 30mg/day. In accordance with improvement of symptom., prednisolone was tapered to 12. 5mg, when methotrexate 20mg/wk was added for the prevention of side effects of long term use of corticosteroids, Conjunctivitis, arthritis, and skin lesions cleared within 7 months. With improvement of symptoms, prednisolone was tapered and methotrexate also was tapered slowly. Physical therapy for joint stiffness was done.
Adrenal Cortex Hormones ; Arthralgia ; Arthritis ; Conjunctivitis ; Fever ; Humans ; Indomethacin ; Joints ; Male ; Methotrexate* ; Prednisolone* ; Salicylic Acid ; Skin ; Sodium ; Young Adult