We present the therapeutic effects of an aromatic retinoid (Ro 10-9359) in two cases of sex-linked ichthyosis. Case 1, Uncle of Case 2, was a 24-year-old male who had had dark brown scales on the trunk and upper extremities for 15 years. Case 2 was a 10-year-old boy who had had dirty brown scales on the trunk and lower extremities since 3 years of age. The diagnosis of sex-linked ichthyosis was made by characteristic scales and histopathologic findings. Initially, both patients received an oral aromatic retinoid (Ro 10-9359) with a daily dose of 1.5mg/kg body weight for the first two weeks. Thereafter the drug was tapered gradually to the dose of 0.5mg/kg body weight according to the therapeutic response. There was near complete clearing of the skin lesions in both patients after 10 weeks treatment. Side effects were of mild intensity and included dryness of mouth and nose, chelitis, paronychia and arthralgia of knee joint.
Arthralgia ; Body Weight ; Child ; Diagnosis ; Humans ; Ichthyosis* ; Knee Joint ; Lower Extremity ; Male ; Mouth ; Nose ; Paronychia ; Skin ; Upper Extremity ; Weights and Measures ; Young Adult

Objective: To compare the H.R neuropsychological functions of urban and rural children and to elucidate possible affecting factors. Methods:57 urban children and 54 rural children between 6.5～7.5 ages were assessed on the Halstead-Reitan Neuropsychological Battery. Results:①The scores of Category, Touch Operating, and Proceeding subtests in H.R.B of urban children were significantly higher than those of rural children.②There were significant differences in parenting behaviors between the parents of urban children and rural children.③There were significant correlations between parenting behaviors and H.R.B performance. Conclusion: Parenting behavior could be an influential factor in the development of neuropsychological functioning in children.

No abstract available.
Animals ; Carcinogenesis* ; Rats*

The usefulness of hyperthermia for cancer therapy has been established. The purpose of the present investigation was to access feasibility of heating normal lung and the temperature and power requirement were compared with that for liver as solid organ in rabbits by using radiofrequent heating machine. In this study, 20 rabbits were divided into 2 groups according to the heating site and the method of temperature measurement ; in group I : lung heating and temperature measuring in skin, esophagus and lung parenchyme ; in group ll : liver heating and temperature measuring in skin and liver parenchyme. The results were as follows ; 1) When the maximum temperature was almost same in lung heating group and liver heating group, the power for liver heating was lesser required than the power for lung heating (p<0.05). 2) The temperature of esophagus for the measurement of mediastinum temperature was 1.1+/-0.9 degrees C higher than the temperature of lung parenchyme (p<0.05). Therefore the above findings suggest lung, air containing organ, is well heated as same as liver, solid organ. So more active trials of lung heating in the lung cancer must be likely considered. But whets the lung is heated, the esophageal temperature is higher than lung parenchyme, so the mediastinum damage must be considered seriously.
Esophagus ; Fever ; Heating* ; Hot Temperature* ; Liver ; Lung Neoplasms ; Lung* ; Mediastinum ; Rabbits ; Skin

No abstract available.
Esophageal and Gastric Varices* ; Hypertension, Portal*

No abstract available.
Depression*

No abstract available.
Animals ; Rats*

Genus of aspergilli are ubiquitous saprophytic molds in nature, which are recognized about 700 species, at least eight are pathologic for human. Pulmonary aspergillosis is rare disease, most frequent presenting as secondary invasion, and aspergillosis of the nasal cavity is the most common sites of the extrapulmonary aspergillosis. Predisposing factors for pulmonary aspergillosis are chronic lung disease, tuberculosis, antibiotics, cytotoxins and neoplasia, hematologic disorders, and histoplasmosis etc. Authors have experienced 10 cases of pulmonary aspergillosis and a case of aspergillosis of nasal cavity in Dept. of Pathol. Chosun univ. hospital and christian hospital from Feb. 1981 to July 1984. Patient of pulmonary aspergillosis are received surgical resection and survived well without complications.
Humans ; Cytotoxins

No abstract available.
Apoptosis*

No abstract available.
Chromium* ; Micronucleus Tests*