A group of chemicals that have proved to be frequent causes of allergic contact dermatitis from applied ingredients of the vehicle. Fisher (1971) testing with a vehicle tray of 15 chemicals in 100 patients with allergic contact dermatitis due to topically administered medications found 30 positive patch test reactions of patients and reported that most important sensitiiing chemicals are Ethylenediamine, Lanolin, Farabens, Phenylmercuric acid, and. propylene glycol monostearate. These chemicals have been recognized as such common sensitizers that they are nonincluded. in the standard patch test series by many countries. From the standpoint of allergenicity of topical preparations including topical medicaments and cosmetics, prevention and diagnostic procedures of dermatitis should be investigated extensively through the patch test studies. But, in our country, there has only a few investigation conceming the dermatitis from vehicle, particularly the medicaments and cosmetics. Therefore, author has tried to establish the vehicle tray fitted to our country according to the basic consideration used with the vehicle patch test tray of Fisher. 100 patients suspected of having allergic contct dermatitis due to topical medication or cosmetics were patch tested with a group of chemicals composed of substances commonly found in vehicles of current topical medications or cosmetics. There were many significant reactions to Ethylenediamine, Paraben, Lanolin, Sodium lauryl sulfate, Polyethylene glycol and Turpentine which play a significant role as solubilzer, antioxidants, emulsifieis, exirpients, preservatives, stabilizers, and surfactants. Author proposed that a group of chemicals should be patch tested on patients of allergic contact dermatitis for the establishmc,nt and development of the hypoallergenic topical medicaments or cosmetics.
Antioxidants ; Dermatitis ; Dermatitis, Allergic Contact* ; Humans ; Lanolin ; Patch Tests ; Polyethylene Glycols ; Propylene Glycol ; Sodium Dodecyl Sulfate ; Surface-Active Agents ; Turpentine

A case of Toxic epidermal necrolysis in 19 th years old man is presented. This patient has been suffering from erythematous patches and bullae over entire body including vesicles, erosions, and fissures on both lips since 2 days ago after taking some drugs (analgetics, aspirin, chloramphenicol, sulfisoxazole, erythromycine.) for treatment of tonsillitis. Furthermore, it is very difficult for us to say why the disease has occured. Toxic Epidermal Necrolysis (TEN) by talking drugs or Staphylococcal Scalded Skin Syndrpme (4S) by staphylococcus aurues because staphylococcus aureus was found on bacteriai culture from his throat swab. He was treated with corticosteroid, antibiotics and fluids for 20 days with good result. Literature was briefly reviewed.
Anti-Bacterial Agents ; Aspirin ; Chloramphenicol ; Humans ; Lip ; Palatine Tonsil ; Pharynx ; Skin ; Staphylococcus ; Staphylococcus aureus ; Stevens-Johnson Syndrome* ; Sulfisoxazole ; Tonsillitis

Familial benign chronic pemphigus is characterized by a recurrent eruption of plaques of closely grouped vesicles that most frequently occurs about the neck, axilla and groin, singly or in combination with similar lesions in the intertriginous area. A 27-year-old male has had recurrent vesicles, fissures, maceration and crust formation in inguinal and perianal area for 3 yeare. The lesion manifested circinated form of vesicles, fissured and scaly patches over the inguinal, scrotal and perianal area. There were actively inflammatory border, resembling tinea cruris in the inguinal area. Authors diagnosed with clinical symptoms, laboratory examinations, and light and electron microscopic examination.
Adult ; Axilla ; Groin ; Humans ; Male ; Neck ; Pemphigus, Benign Familial* ; Tinea

Epidermolysis Bullosa Simplex is characterized by autosomal dominant rnheritance, and chronic noninflammatory conditions in which the clinical lesions, erosion, blisters usually result from relatively minor mechanical trauma to the skin, especially joints of hands, elbows, knees, and feet and other sites subject to repeated trauma The lesiona are present or appeared after a few days after birth or shortly after especialy of the lower legs or feet, and not involved at naiIs or mucous membranes. Though infection is not common on the feet or hands, even infected lesions generally heal with out scarring. 2 cases of Epidermolysis bullosa simplex were experienced, the one was 5 month old male baby who had fresh vesiculobullous, hemorrhagic bulla, crusts, exfoliation, no nail dystrophy, since a few days after birth. The another was 5 month old female baby, who had pea sized tense bulla, and exfoliations on the hands and feet. Diagnosis confirmed by clinical features and histological findings. Literature were reviewed in comparison with mechanobulIous disease.
Blister ; Cicatrix ; Diagnosis ; Elbow ; Epidermolysis Bullosa Simplex* ; Epidermolysis Bullosa* ; Female ; Foot ; Hand ; Humans ; Infant ; Joints ; Knee ; Leg ; Male ; Mucous Membrane ; Parturition ; Peas ; Skin ; Transcutaneous Electric Nerve Stimulation

No abstract available.
Humans ; Incontinentia Pigmenti* ; Male*

We present the therapeutic effects of an aromatic retinoid (Ro 10-9359) in two cases of sex-linked ichthyosis. Case 1, Uncle of Case 2, was a 24-year-old male who had had dark brown scales on the trunk and upper extremities for 15 years. Case 2 was a 10-year-old boy who had had dirty brown scales on the trunk and lower extremities since 3 years of age. The diagnosis of sex-linked ichthyosis was made by characteristic scales and histopathologic findings. Initially, both patients received an oral aromatic retinoid (Ro 10-9359) with a daily dose of 1.5mg/kg body weight for the first two weeks. Thereafter the drug was tapered gradually to the dose of 0.5mg/kg body weight according to the therapeutic response. There was near complete clearing of the skin lesions in both patients after 10 weeks treatment. Side effects were of mild intensity and included dryness of mouth and nose, chelitis, paronychia and arthralgia of knee joint.
Arthralgia ; Body Weight ; Child ; Diagnosis ; Humans ; Ichthyosis* ; Knee Joint ; Lower Extremity ; Male ; Mouth ; Nose ; Paronychia ; Skin ; Upper Extremity ; Weights and Measures ; Young Adult

Erythema dyschromicum perstans is a cutaneous pigmentary dermatosis of unknown etiology chararcterizd by asymptomatic macules of an ashy gray color which was first presented by Ramirez. We reported a case of Erythema dyschromicum perstans in 57 year old female patient. The skin lesion were characterized by the presence of discreated or confluented bluish-gray colored pigrnentation on the lateral surface of hoth upper extremities. Histologically, the lesion showed hydropic degeneration of the epidermis witb in continence of pigmcnt and an apperence of malanin-hearing macrophages in upper dermis which are compatible with Erythema dyschromicum perstans.
Dermis ; Epidermis ; Erythema* ; Female ; Humans ; Macrophages ; Middle Aged ; Skin ; Skin Diseases ; Upper Extremity

Urticaria pigmentosa is a manifestation of mastocytosis characterized by persistent pigmented cutaneous lesions of various size that tend to urticate upon mechanical or chemical irritation, The disease is most common in ehildren and skin lesions after appear within 1 or 2 months of birth. Urticaria pigmentosa in children begins with disseminated eruption (buIlou type) or with a solitary tumor or nodule(solitary type). One case. of solitary type and one case of bullous type are reported in this paper. The one case is a solitary type of urticaria pigmentosa in 1 1/2 years old male who had dark brownish pigmented nodule(2.5 1cm) on right hack since 1 year ago. Tie other is a bullous type of urticaria pigmentousa in 6 months old male who had generalizcd. bulla, hemorragic bulla with crust & millium since 4 months ago. Dignosis was confirmed by histologic findings in which showed infiltration of mast cells in upper nr entire dermis arui rnetachromatic granules in mast cell on toluidine blue stain. Literature were reviewed briefly.
Child ; Dermis ; Humans ; Infant ; Male ; Mast Cells ; Mastocytosis ; Parturition ; Skin ; Tolonium Chloride ; Urticaria Pigmentosa* ; Urticaria*

Poikilodermatomyositis is a variant of dermatomyositis which is characterized by polymyositis associated with mottled dark brownish pigmentation, seattered atrophic patch and telangiectasia of the skin. Poikiloderma usually occurs in patient with long standing dermatomyositis. The authors observed a case of typical poikilodermatomyositis in a 40-year-old male. Skin examination revealed dark brownish pigmentation, telangiectasia and whitish atrophic patches on entire body. Muscles of shoulder girdle were markedly wasted. Muscle weakness was so severe that he could not elevate his arm above shoulder level. He also had difficulty in going up stairs. Histopathologic findings of the skin were similar to those of poikiloderma vasculare atrophicans. Light microscopic and eIectronmicroscopic examination of muscle reveaIed myositis.
Adult ; Arm ; Dermatomyositis ; Humans ; Male ; Muscle Weakness ; Muscles ; Myositis ; Pigmentation ; Polymyositis ; Shoulder ; Skin ; Telangiectasis

Epidermolysis bullosa dystrophica is a rare, chronic non-infIammatory mechanobullous disease of hereditsry trait, which easily produces bulla by minor injury or spontaneously. Bullae usually developed first at birth or in infancy, involving especially hands, feet, knees, elbows and other pressure sites, which heal with atrophic and hypertrophic scars, loss of hair and nails, digital fusion, flexural contractures of the knee, elbow and wrist joints. A 5-year-old boy has had various sized recurrent buIlae on hands, feet, kneces and elbows, healed with atrophy of skin, miliums, deformities of toe and finger nails. Diagnosis was confirmed by clinical features and electronmicroscopic findings. Literature were reviewed briefly.
Atrophy ; Child, Preschool ; Cicatrix, Hypertrophic ; Congenital Abnormalities ; Contracture ; Diagnosis ; Elbow ; Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa* ; Fingers ; Foot ; Hair ; Hand ; Humans ; Knee ; Male ; Parturition ; Skin ; Toes ; Wrist Joint