A group of chemicals that have proved to be frequent causes of allergic contact dermatitis from applied ingredients of the vehicle. Fisher (1971) testing with a vehicle tray of 15 chemicals in 100 patients with allergic contact dermatitis due to topically administered medications found 30 positive patch test reactions of patients and reported that most important sensitiiing chemicals are Ethylenediamine, Lanolin, Farabens, Phenylmercuric acid, and. propylene glycol monostearate. These chemicals have been recognized as such common sensitizers that they are nonincluded. in the standard patch test series by many countries. From the standpoint of allergenicity of topical preparations including topical medicaments and cosmetics, prevention and diagnostic procedures of dermatitis should be investigated extensively through the patch test studies. But, in our country, there has only a few investigation conceming the dermatitis from vehicle, particularly the medicaments and cosmetics. Therefore, author has tried to establish the vehicle tray fitted to our country according to the basic consideration used with the vehicle patch test tray of Fisher. 100 patients suspected of having allergic contct dermatitis due to topical medication or cosmetics were patch tested with a group of chemicals composed of substances commonly found in vehicles of current topical medications or cosmetics. There were many significant reactions to Ethylenediamine, Paraben, Lanolin, Sodium lauryl sulfate, Polyethylene glycol and Turpentine which play a significant role as solubilzer, antioxidants, emulsifieis, exirpients, preservatives, stabilizers, and surfactants. Author proposed that a group of chemicals should be patch tested on patients of allergic contact dermatitis for the establishmc,nt and development of the hypoallergenic topical medicaments or cosmetics.
Antioxidants ; Dermatitis ; Dermatitis, Allergic Contact* ; Humans ; Lanolin ; Patch Tests ; Polyethylene Glycols ; Propylene Glycol ; Sodium Dodecyl Sulfate ; Surface-Active Agents ; Turpentine

A case of Toxic epidermal necrolysis in 19 th years old man is presented. This patient has been suffering from erythematous patches and bullae over entire body including vesicles, erosions, and fissures on both lips since 2 days ago after taking some drugs (analgetics, aspirin, chloramphenicol, sulfisoxazole, erythromycine.) for treatment of tonsillitis. Furthermore, it is very difficult for us to say why the disease has occured. Toxic Epidermal Necrolysis (TEN) by talking drugs or Staphylococcal Scalded Skin Syndrpme (4S) by staphylococcus aurues because staphylococcus aureus was found on bacteriai culture from his throat swab. He was treated with corticosteroid, antibiotics and fluids for 20 days with good result. Literature was briefly reviewed.
Anti-Bacterial Agents ; Aspirin ; Chloramphenicol ; Humans ; Lip ; Palatine Tonsil ; Pharynx ; Skin ; Staphylococcus ; Staphylococcus aureus ; Stevens-Johnson Syndrome* ; Sulfisoxazole ; Tonsillitis

The solitary type of Koratoacanthoma is a common, rapidly growing, benign tumor with a natural history of spontaneous involution which was first described by Hutchinson in 1889. It was well known that this Keratoacanthoma is close resemblence to squamous cell carcinoma clinicallt & histopathology. The etiology of Kertoacanthoma is ucertain but it have been associated with many exogenous factors, including sun exposure, occupational exposure to heat and trauma, and tar and with autoimmune etiology and viral infection. We experienced 2 cases of soitary type of Keratoacantoma with typical clinical and histopathologic findings which presented on the pubic area and forehead but had no predisposing factors of Keratoacanthoma. The one was 66-year-old woman who had been a history of proritic, rapidly growing tumor on Mons Pubis since about 6 months ago. The another one was 40 year-old male who had been a history of asymromatic, growing tomor on forehead since about 3 months ago. In the H-E stained sections, there were horn filled invagination, dyskeratotic cell, horn pearl in the epidermis and an inflammatory infiltration in dermis. Diagnosis was cinfirmedby the clinical and histopatholigical pictures. The former was treated by electrocautery after simple excision and the latter by curretage and electrodesiccation.
Adult ; Aged ; Animals ; Carcinoma, Squamous Cell ; Causality ; Dermis ; Diagnosis ; Electrocoagulation ; Epidermis ; Female ; Forehead ; Horns ; Hot Temperature ; Humans ; Keratoacanthoma* ; Male ; Natural History ; Occupational Exposure ; Solar System

Epidermolysis bullosa Dystrophica is rare, chronic non-mflammatory mechanobullous disease of hereditary trait, which easily produces bulIa by minor trauma or spontaneousIy. The lesions usually appears from birth or in infant involving especially lower leg, hand, foot and lea,ds to erosive, hemorrhagic bulla, secondary infection, pruritus and scar formation and sometimes deformity of nails and cicatrical alopecia. It sometimes involves oral mucosa, esophagus, eye, tooth, bone, respiratory system, anus and vagina. This disease has rare tendency for carcinogenesis from cicatrical Iesions. These manifestations are more severe in recessive type than in dominant type. We had observed 5 cases of EBD at Ewha Womans University Hospital from Sept. 1975. to Jul. 1976. Among 5 cases, 4 cases occurred from birth, 1 case occurred at age l. Skin lesivns were hand, foot, knee area in all 5 cases. Head, face were involved in 2 cases. Arm, leg, trunk, buttock were involved in 3 cases. In skin manifestations, bulla, erosive bulla, secondary infection, scar formation, pruritus, nail deformity, positive Nikolsky sign were observed in all 5 cases. Hemorrhagic bulla, miliaria. were presented, in 1 case, alopecia in 2 cases. Aggrevated season were summer in 4 cases, spring in 1 case, HistologicalIy, microscopic observation, after H@-E stain, revealed hyperkeratosis in 3 cases, acanthosis in 2 cases, partial atrophy in 1 case, partial ulcer in 1 case, snbepidermal bulla in 5 cases, chronic nonspecific inflamma- tory cell infiltration of upper dermis in 3 cases, fibrosis of lower dermis in 1 case.
Alopecia ; Anal Canal ; Arm ; Atrophy ; Buttocks ; Carcinogenesis ; Cicatrix ; Coinfection ; Congenital Abnormalities ; Dermis ; Epidermolysis Bullosa Dystrophica* ; Epidermolysis Bullosa* ; Esophagus ; Female ; Fibrosis ; Foot ; Hand ; Head ; Humans ; Infant ; Knee ; Leg ; Miliaria ; Mouth Mucosa ; Parturition ; Pruritus ; Respiratory System ; Seasons ; Skin ; Skin Manifestations ; Tooth ; Ulcer ; Vagina

The pathogenesis of vitiligo has not been fully elucidated, but three different hypothese have been advanced to explain the cause of vitiligo. One is related to autoimmunity, another concerns neurohumoral factors and the third involves self-destruction of melanocytes. The autoimmune theory of vitiligo is further strengthened by the increased association of vitiligo with a nurnber of autoimmune disorders and by the increased prevalence of organ-specific autoantibodies in vitiligo. Also decreased T lymphocytes in vitiligo patients were reported. The present study was undertaken to evaluate the cell mediated immune status of patients with vitiligo using several in vitro and in vivo immune parameters. Thirty patients between the ages of 12 and 65 were observed at the Department of Dermatology of Ewha Womans University Hospital from Apri11981 through October 1981. Age matched 30 healthy persons comprised the control group. The results were summarized as follow: 1) The mean percentage of T lymphocytes in 30 vitiligo subjects and 30 control subjects were 55.3% and 67.4% respectively. There was a significant decrease of T lymphocytes in patients with vitiligo(p<0.05). 2) The percentage of subjects showing positive delayed hypersensitivity reactions to candidin, trichophytin and PPD were 33.3%, 43%, 50% respectively in 30 vitiligo patients and 60%, 75%, 80% respectively in 20 controls. A slight depression in delayed cutaneous hypersensitivity in gatients with vitiligo. (p<0.1). 3) The percentage of subjects showing positive sensitization with DNCB was 53% in 30 vitiligo patienta and 85% in 20 controls. A slight depression in DNCB sensitization was evident in vitiligo patients(p<0.1).
Autoantibodies ; Autoimmunity ; Depression ; Dermatology ; Dinitrochlorobenzene ; Female ; Humans ; Hypersensitivity ; Hypersensitivity, Delayed ; Immunity, Cellular* ; Melanocytes ; Prevalence ; T-Lymphocytes ; Trichophytin ; Vitiligo*

Epidermolysis Bullosa Simplex is characterized by autosomal dominant rnheritance, and chronic noninflammatory conditions in which the clinical lesions, erosion, blisters usually result from relatively minor mechanical trauma to the skin, especially joints of hands, elbows, knees, and feet and other sites subject to repeated trauma The lesiona are present or appeared after a few days after birth or shortly after especialy of the lower legs or feet, and not involved at naiIs or mucous membranes. Though infection is not common on the feet or hands, even infected lesions generally heal with out scarring. 2 cases of Epidermolysis bullosa simplex were experienced, the one was 5 month old male baby who had fresh vesiculobullous, hemorrhagic bulla, crusts, exfoliation, no nail dystrophy, since a few days after birth. The another was 5 month old female baby, who had pea sized tense bulla, and exfoliations on the hands and feet. Diagnosis confirmed by clinical features and histological findings. Literature were reviewed in comparison with mechanobulIous disease.
Blister ; Cicatrix ; Diagnosis ; Elbow ; Epidermolysis Bullosa Simplex* ; Epidermolysis Bullosa* ; Female ; Foot ; Hand ; Humans ; Infant ; Joints ; Knee ; Leg ; Male ; Mucous Membrane ; Parturition ; Peas ; Skin ; Transcutaneous Electric Nerve Stimulation

Familial benign chronic pemphigus is characterized by a recurrent eruption of plaques of closely grouped vesicles that most frequently occurs about the neck, axilla and groin, singly or in combination with similar lesions in the intertriginous area. A 27-year-old male has had recurrent vesicles, fissures, maceration and crust formation in inguinal and perianal area for 3 yeare. The lesion manifested circinated form of vesicles, fissured and scaly patches over the inguinal, scrotal and perianal area. There were actively inflammatory border, resembling tinea cruris in the inguinal area. Authors diagnosed with clinical symptoms, laboratory examinations, and light and electron microscopic examination.
Adult ; Axilla ; Groin ; Humans ; Male ; Neck ; Pemphigus, Benign Familial* ; Tinea

No abstract available.
Humans ; Incontinentia Pigmenti* ; Male*

We present the therapeutic effects of an aromatic retinoid (Ro 10-9359) in two cases of sex-linked ichthyosis. Case 1, Uncle of Case 2, was a 24-year-old male who had had dark brown scales on the trunk and upper extremities for 15 years. Case 2 was a 10-year-old boy who had had dirty brown scales on the trunk and lower extremities since 3 years of age. The diagnosis of sex-linked ichthyosis was made by characteristic scales and histopathologic findings. Initially, both patients received an oral aromatic retinoid (Ro 10-9359) with a daily dose of 1.5mg/kg body weight for the first two weeks. Thereafter the drug was tapered gradually to the dose of 0.5mg/kg body weight according to the therapeutic response. There was near complete clearing of the skin lesions in both patients after 10 weeks treatment. Side effects were of mild intensity and included dryness of mouth and nose, chelitis, paronychia and arthralgia of knee joint.
Arthralgia ; Body Weight ; Child ; Diagnosis ; Humans ; Ichthyosis* ; Knee Joint ; Lower Extremity ; Male ; Mouth ; Nose ; Paronychia ; Skin ; Upper Extremity ; Weights and Measures ; Young Adult

Poikilodermatomyositis is a variant of dermatomyositis which is characterized by polymyositis associated with mottled dark brownish pigmentation, seattered atrophic patch and telangiectasia of the skin. Poikiloderma usually occurs in patient with long standing dermatomyositis. The authors observed a case of typical poikilodermatomyositis in a 40-year-old male. Skin examination revealed dark brownish pigmentation, telangiectasia and whitish atrophic patches on entire body. Muscles of shoulder girdle were markedly wasted. Muscle weakness was so severe that he could not elevate his arm above shoulder level. He also had difficulty in going up stairs. Histopathologic findings of the skin were similar to those of poikiloderma vasculare atrophicans. Light microscopic and eIectronmicroscopic examination of muscle reveaIed myositis.
Adult ; Arm ; Dermatomyositis ; Humans ; Male ; Muscle Weakness ; Muscles ; Myositis ; Pigmentation ; Polymyositis ; Shoulder ; Skin ; Telangiectasis