INTRODUCTION: In 1910 phenylephrine hydrochloride was introduced first by Barger and Dale. Phenylephrine hydrochloride is a synthetic sympathomimetic compound structurally similar to epinephrine and ephedrine. Synthetic phenylephrine hydrochloride is clinically used as a nasal decongestant, vasopressor and mydriatic, etc.. The use of phenylephrine hydrochloride in ophthalmological practice is based on its action of vasoconstriction and mydriasis. Phenylephrine hyrdochloride has been introduced in U.S.A. as 10 % neosynephrine (U.S.P.) and in Japan as 5 % neosynesine. It's usefulness in therapy and examination is due to the following characteristics; (1) Rapid effect, (2) No influence on intraocular pressure nor on accommodation, (3) No undesirable side reaction. In many countries including U.S.A. and Japan. they reported experimentally and clinically in detail about the mydriatic action of phenylephrine hydrochloride but unfortunately there is no data concerning mydriatic action of phenylephrine hydrochloride in Koreans in spite of its wide use in ophthalmology. The study was performed for dilatation of the pupil, influence on intraocular pressure and accommodation, antagonistic action to pilocarpine, and side reaction after instillation of 10 % neosynephrine (U.S.P.) by the following method. METHOD AND MATERIAL: Material; 10 % Neosynephrine hydrochloride (U.S.P.), 2 % Pilocarpine. Subjects; 228 Korean normal eyes (6-84 yrs. old). METHOD: 1. Dilatation of the pupil (176 eyes). Group 1; One drop of 10 % neosynephrine instilled into 75 eyes. Over 60 yrs. old--10 eyes, 36-59 yrs. old--17 eyes, Under 35 yrs. old--48 eyes. Group 2; Two drops of 10 % neosynephrine instilled into 59 eyes. Over 60 yrs. old--2, eyes 39-59 yrs. old--17 eyes, Under 35 yrs, old--40 eyes. Group 3; Three drops of 10 % neosynephrine instilled into 42 eyes. Over 60 yrs. old--7 eyes, 36-59 yrs. old-14 eyes, Under 35 yrs. old-21 eyes. Interval between each instillation was two or three minutes. After instillation of 10 % neosynephrine into the eyes, the diameter of the pupils was measured frequently till maximum dilatation. 2. Influence on the intraocular pressure (25 eyes). After measurement of the intraocular pressure and diameter of the pupil in eacheyes, one drop of 10 % neosynephrine was instilled into 9 eyes and two drops into 10 eyes, and three drops into 6 eyes. After that measurement of intraocular pressure and diameter of the pupil was done every 10 minutes for 90 minutes and 2 and 3 hrs. later. 3. Influence on accommodation. The diameter of the pupil and distance of N.P.C. were measured before instillation of neosynephrine and every 10 minutes interval for 90 minutes and at 2 and 3 hrs. after instillation of 10 % neosynephrine into 23 eyes (one drop into 8 eyes, two drops into 10 eyes, three drops into 5 eyes). 4. Antagonistic action of 2 % pilocarpine to mydriatic action of 10 % neosynephrine. In two eyes of a 26 yrs. old man, diameter of the pupil was measured and compared in both eyes before instillation of one drop of 10 % neosynephrine and in 10 minutes interval to 90 minutes, at 2 and 3 hrs. after instillation of one drop of 10 % neosynephrine intoboth eyes. Then one drop of 2 % pilocarpine was instiIled into only the right eye at 50 minutes after first instillation of neosynephrine. One drop of 10 % neosynephrine was instilled into both eyes of a 23 yrs. old man, two drops into both eyes of a 20 yrs. old man. and three drops into both eyes of a man aged 22 yrs. One drop of 2 % pilocarpine was instilled into only the right eye of each person, respectively at 40 minutes (22 yrs. old eye), 50 minutes (20 yrs. old eye), and 60 minutes. (23 yrs. old eye) after first instillation of neosynephrine. The diameter of the pupil, the distance of N.P.c., and the intraocular pressure were measured and compared in both eyes of each person befere instillation and at 10 minutes intervals for 90 minutes. and at two and three hrs. after first instillation. RESULTS AND CONCLUSION: 1. In most of 176 eyes, the diameter of the pupils reached more than 7.5mm (maximum dilatation) and they took an average of 42 minutes to reach their maximum dilatation Among them, the shortest was 26 minutes and the longest 75 minutes. 2. The time the pupil takes to reach its maximum dilatation is a little differance between group 1 (one drop of neosynephrne instilled) and group 2 (two drops of neosynephrine instilled) but definetely shorter in group 3 (three drops of neosynepphrine instilled). 3. 10 % neosynephrine has little influence on intraocular pressure. 4. 10 % neosynephrine has slight influence on accommodation (slight paresis of accommodation) in about half of 26 eyes hut they have no disturbance at near work (Table 2 and 3). 5. 2 % pilocarpine constricts the dilated pupil more quickly than if not used (Table 4.). 6. Age has no effect on dilatation of the pupil due to instillation of 10 % neosynephrine. 7. No undesirable side reaction was noted.
Dilatation ; Ephedrine ; Epinephrine ; Humans ; Intraocular Pressure ; Japan ; Mydriasis ; Ophthalmology ; Paresis ; Phenylephrine* ; Pilocarpine ; Pupil ; Vasoconstriction

No abstract available.
Ophthalmology*

BACKGROUND: Tinea versicolor may be treated by topical oroal antifungal drugs. OBJECTIVE: Ihe objertive of this study was to evaluate the their, peutic effect and safety of oral itraconazole(100-200mg/day), cloconazole cream, 20% sodium chiosulfate solution, sulconazole cream and 2% ketoconazole shampoo in Tinea versicolor. METHODS: Forty patients with Tinea versicolor were studys clinically and treated in five groups, with oral itraconazxale(100-200mg/day), cloconazole crean 20% sodium thiosulfate solution, sulconazole cream and 2% ketoconazole shampoo, from JuIIy 1991 to June, 1994. The writers also compared the results with the writers previous similar studies in 1986, 1990. RESULTS: The average age was 29.9 years, the oldest patient were 52 year-old and the youngest patient was a 14 year-old. The ratio of male to female a 1.2: 1. The distributions of lesions was most common in the axilla(26.9%), and the other sitsuere the anterior chest(19.2%), the back(17.3%), the neck(15.4%), the upper extremites(9.6%) the abdomen(7.7%) and the lower extremites(3.9%), in order. The incidence of hyperpigrietted lesions was 76.8% and of hypopigmented lesions was 23.2%. The average duration of treatment until cure was 3.00+0.55 weeks in the oral itraconaxile treated group, 3.31+1.18 weeks in the cloconazole cream group, 3. 25+1.03 weeks in the 20%, sodium thiosulfate solution group 3.45+0.52 weeks in the sulconazole cream group and 3.40+0.33 weeks in the 2% ketoconazole shapen group. Mere were no statistically significant differences of therapeutic efficacy in each the five groups(p>0.05). Compared with the study in 1990, the average age was higher from 5.7 to 29.9 years, and the male to female ratio was slightly less, showing a relative increase in male incidence. But, there was no statistical difference in therapeutic efficacy(p>0.05). CONCLUSION: This study was shown that the above five theraieric regimens can be used safely and simply, according to patients preferences.
Adolescent ; Female ; Humans ; Incidence ; Ketoconazole ; Male ; Middle Aged ; Sodium ; Tinea Versicolor* ; Tinea*

Molluscum contagiosum is a contagious disease of the skin charaterized by the appearance of small globular, umblicated epithelial tumors, and caused by a virus of pox virus group. Authors experienced a case of molluscum contagiosum on the right upper and lower eyelids. And there was follicular conjunctivitis, but no corneal complication. The lesion was managed by simple extraction of the lesion under the local infiltration anesthesia.
Adenocarcinoma ; Aged, 80 and over ; Anesthesia, Local ; Biopsy ; Conjunctivitis ; Eyelids* ; Female ; Humans ; Meibomian Glands* ; Molluscum Contagiosum* ; Skin

A 33 years old house wife with accessory breast tissue is described and the literature is reviewed. The patient developed soft tumors in both axillae with axillary hair loss during the 8 th month of her 8 th pregnancy. This disorder is rather common in the literature but has been paied little attention dermatology.
Adult ; Axilla ; Breast* ; Dermatology ; Hair ; Humans ; Pregnancy ; Spouses

Mixed tumor that occurs in the orbit is very rare but takes a great part of the tumors of the lacrimal glands. It is so pleomorphic that a great deal of confusion exists as to the nature and histogenesis. The tumor appears as a palpable mass in the upper and outer quadrant of the orbit. Usually the tumor is hard, nodular and slightly mobile, lying just underneath the orbital rim. The tumor causes exophthalmos associated with proptosis and some limitation of motion. The treatment of the choice is radical excision of the tumor and followed by x-ray radiation. A 40 year old Korean woman had a hard, nontender mass on the left supraorbital region which had developed for about three years. The encapsulated orbital tumor was removed surgically and found to be a mixed tumor histopathologically.
Adult ; Deception ; Exophthalmos ; Female ; Humans ; Lacrimal Apparatus* ; Male ; Orbit ; Orbit* ; Young Adult

Two cases with generalized G.A. were described. The first case was 42 years, old farmer representing slightly erythematous multiple papulonodular lesions on the face, neck, scapular areas, arms and dorsal hands. Coalescence of lesions in some areas of the dorsal hands and neck produced circinate or polycyclic pattern. The second case was 4 years old girl who developed purple to brown muliple papulonodular lesions and polygonal or round plague on the arms, dorsal hands, palms, neck, iliac crests, lower legs, dorsal feet and sole. The plague lesions mimick lichen planus.
Arm ; Child, Preschool ; Female ; Foot ; Granuloma Annulare* ; Granuloma* ; Hand ; Humans ; Leg ; Lichen Planus ; Neck ; Plague

No Abstract Available.
Adult* ; Capsulorhexis* ; Cataract* ; Follow-Up Studies* ; Humans

Persistent hyperplastic primary vitreous(PHPV) is a congnital abnormality of the embryonic intraocular vasculature, resulting from the failure of regression of the primary vitreous in a full-term infant. PHPV is usually unilateral and characterized by leukocoria, elongated ciliary process, microphthalmia, cataract, rubeosis iridis, shallow anterior chamber, and secondary glaucoma. PHPV finally develops into retinal detachment, intractable glaucoma, and pthisis bulbi. Surgical treatment, involving lensectomy and vitrectomy, is not successful and poor visual result is obtained due to retinal abnormalities. A one-month-old girl was found to have persistent hyperplastic primary vitreous in both eyes, and she expired of unknown etiology at home 2 months after diagnosls.
Anterior Chamber ; Cataract ; Female ; Glaucoma ; Humans ; Infant ; Microphthalmos ; Persistent Hyperplastic Primary Vitreous* ; Retinal Detachment ; Retinaldehyde ; Vitrectomy

Recently hang-back recession is chosen instead of conventional recession to get better result in strabismus surgery. Jampolsky method, a popular method of hang-back recession, has some draw-backs; the extraocular muscle width can be decreased, the center of the muscle can be sagging posteriorly, and the amount of recession can be somewhat shortened than expected in operation. Accordingly, we devised a new modified hang-back recession and compared with Jampolsky method. Two months after respective operation in 7 albino rabbits, the width of the muscle comparing to preoperative condition, the amount of recession, and the sagging of middle part of the muscle were evalvated in comparison with the preoperative findings. The width of muscles was significantly shortened in Jampolsky method in comparison with preoperative condition (p<0.05), but not in our new method (p>0.05). The amount of recession by Jampolsky method was significantly shortened than expected in operation (p<0.05), but not by our new method (p>0.10). The significant sagging of the muscle was found with Jampolsky method (p<0.05), but not with our modified method (p>O.lO). In review of these findings, our new method is devoid of some draw backs of Jampolsky method.
Muscles ; Rabbits ; Strabismus