1.Antifungal active triterpene glycosides from sea cucumber Holothuria scabra.
Hua HAN ; Yang-Hua YI ; Ling LI ; Bao-Shu LIU ; Ming-Ping LA ; Hong-Wei ZHANG
Acta Pharmaceutica Sinica 2009;44(6):620-624
To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A (1), echinoidea A (2) and holothurin A1 (3). Scabraside A (1) is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities (1 < or = MIC80 < or = 16 microg mL(-1)).
Animals
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Antifungal Agents
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isolation & purification
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pharmacology
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Glycosides
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chemistry
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isolation & purification
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pharmacology
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Holothuria
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chemistry
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Holothurin
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analogs & derivatives
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chemistry
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isolation & purification
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pharmacology
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Molecular Structure
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Triterpenes
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chemistry
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isolation & purification
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pharmacology