The study on Holarrhena antidysenterica Wall was carried out in Chi Linh (Hai Duong province) in September 2004. Leaves of Holarrhena antidysenterica Wall were collected, dried, grilled to powder, then extracted and isolated flavonoid. Two flavonoids were isolated, on the base of m.p, UV, IR, MS, 1H-NMR, 13C-NMR, DEPT analyses, they were identified as Kaempferol and Quercetin. This is the first time the flavonoids were reported as a substance isolated from Holarrhena antidysenterica Wall in Vietnam
Flavonoids ; Holarrhena ; Vietnam

Two new steroidal alkaloids, isoconkuressine and N-formylconessimine, together with 6 known steroidal alkaloids including conkuressine, conessine, isoconessimine, conimine, conarrhimine, and funtudienine, were isolated from the seeds of Holarrhena antidysenteriaca Wall.ex A.DC. Their intrinsic antibacterial activities and synergistic effects with penicillin and vancomycin were analyzed in methicillin sensitive staphylococcus aureus (MSSA) and methicillin resistant staphylococcus aureus (MRSA). Two of the steroidal alkaloids including one new compound (N-formylconessimine) showed potential antibacterial activity and possessed synergistic effects with penicillin and vancomycin, respectively.
Alkaloids ; isolation & purification ; pharmacology ; Anti-Bacterial Agents ; chemistry ; isolation & purification ; pharmacology ; Holarrhena ; chemistry ; Methicillin-Resistant Staphylococcus aureus ; drug effects ; Microbial Sensitivity Tests ; Plant Extracts ; chemistry ; isolation & purification ; pharmacology ; Staphylococcus aureus ; drug effects