1.Results of skin prick test, serum total IgE and peripheral eosinophil count in allergic patients in Kyungpook area.
Gyu Hoi KIM ; Ki Heum PARK ; Ye Bong LEE ; Chang Heon YANG ; Chang Woo LEE ; Yeong Hyeon LEE
Journal of the Korean Academy of Family Medicine 1993;14(3):132-139
No abstract available.
Eosinophils*
;
Gyeongsangbuk-do*
;
Humans
;
Immunoglobulin E*
;
Skin*
2.Replantation of Hand Amputated Through the Palmar Arch Level
Myung Chul YOO ; Shin Hyeok KANG ; Hoi Chang KIM ; Young Girl LEE
The Journal of the Korean Orthopaedic Association 1982;17(5):845-853
The value of replantation of parts of the upper limb is well established and replantation of a digit has now be come a standard procedure. However, there are few reports of replantation of hand amputated through the palmar arch level. We have reviewed 14 cases of 14 patients replantation of hand amputated through the arterial palmar arch level from Mar. 1976 through Mar. 1982. The success rate in our series is 64 percent. This is slightly lower than the other levels due to its anatomical complexity. According to the anatomical complexity and distribution of nerves and vessels, it is divided to three levels. In level A, the superficial palmar arch and/or the deep palmar arch should be repaired. In level B, the princeps pollicis artery should be repaired after anastomosis of the superficial and deep palmar arch. In level C, each common palmar digital artery should be repaired but if it is impossible to repair of all fingers, replantation of thumb and index should be performed as possible. Meticulous microsurgical technique and precise anatomical knowledge is mandatory for replantation of the palmar arch level.
Arteries
;
Extremities
;
Fingers
;
Hand
;
Humans
;
Replantation
;
Thumb
;
Upper Extremity
3.The effect of plasmapheresis in the management of Guillain-Barre syndrome.
In Sung LEE ; Chang Hun YUE ; Hee Sang KIM ; Kyong Hoi AHN
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(1):36-41
No abstract available.
Guillain-Barre Syndrome*
;
Plasmapheresis*
4.Pseudosarcoma of the esophagus: one case report.
Chang Hoi KIM ; Keon LEE ; Hyung Joo PARK ; Young Ho CHOI ; Hark Jei KIM ; Hyoung Mook KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(12):1197-1200
No abstract available.
Esophagus*
5.Clinical analysis on relation between blood flow and patency of arteriovenous fistula for hemodialysis.
Chang Hoi KIM ; Keon LEE ; Hyung Joo PARK ; Young Ho CHOI ; Hark Jei KIM ; Hyoung Mook KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(12):1167-1172
No abstract available.
Arteriovenous Fistula*
;
Renal Dialysis*
6.Deep Cerebral Venous Thrombosis Showing Parkinsonism such as Micrographia, Hypophonia and Bradykinesia.
Seung Hoi LEE ; Hyuk CHANG ; Yo Sik KIM
Journal of the Korean Neurological Association 2002;20(2):187-190
Deep cerebral venous thrombosis is a rare condition associated with edema, infarction or hemorrhage in basal ganglia, thalamus and periventricular white matter. It presents nonspecific clinical manifestations such as altered consciousness, headache, focal neurological deficit, nausea and vomiting. Extrapyramidal signs are very rare in deep cerebral venous thrombosis. We report a patient who presented micrographia, hypophonia and bradykinesia as an early manifestation of deep cerebral venous thrombosis.
Basal Ganglia
;
Consciousness
;
Edema
;
Headache
;
Hemorrhage
;
Humans
;
Hypokinesia*
;
Infarction
;
Nausea
;
Parkinsonian Disorders*
;
Thalamus
;
Venous Thrombosis*
;
Vomiting
7.Resveratrol suppresses breast cancer cell invasion by inactivating a RhoA/YAP signaling axis.
Yu Na KIM ; So Ra CHOE ; Kyung Hwa CHO ; Do Yeun CHO ; Jaeku KANG ; Chang Gyo PARK ; Hoi Young LEE
Experimental & Molecular Medicine 2017;49(2):e296-
Hippo/YAP signaling is implicated in tumorigenesis and progression of various cancers. By inhibiting a plethora signaling cascades, resveratrol has strong anti-tumorigenic and anti-metastatic activity. In the present study, we demonstrate that resveratrol decreases the expression of YAP target genes. In addition, our data showed that resveratrol attenuates breast cancer cell invasion through the activation of Lats1 and consequent inactivation of YAP. Strikingly, we also demonstrate that resveratrol inactivates RhoA, leading to the activation of Lats1 and induction of YAP phosphorylation. Further, resveratrol in combination with other agents that inactivate RhoA or YAP showed more marked suppression of breast cancer cell invasion compared with single treatment. Collectively, these findings indicate the beneficial effects of resveratrol on breast cancer patients by suppressing the RhoA/Lats1/YAP signaling axis and subsequently inhibiting breast cancer cell invasion.
Breast Neoplasms*
;
Breast*
;
Carcinogenesis
;
Humans
;
Phosphorylation
8.Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin
Bo Young JEONG ; Kyung Hwa CHO ; Kang Jin JEONG ; Yun Yong PARK ; Jin Man KIM ; Sun Young RHA ; Chang Gyo PARK ; Gordon B MILLS ; Jae Ho CHEONG ; Hoi Young LEE
Experimental & Molecular Medicine 2018;50(1):e435-
The small GTP-binding protein Rab25 is associated with tumor formation and progression. However, recent studies have shown discordant effects of Rab25 on cancer cell progression depending on cell lineage. In the present study, we elucidate the underlying mechanisms by which Rab25 induces cellular invasion. We demonstrate that Rab25 increases β1 integrin levels and subsequent activation of EGFR and upregulation of VEGF-A expression, leading to increased Snail expression, epithelial-to-mesenchymal transition and cancer cell invasiveness. Strikingly, we identify that Snail mediates Rab25-induced cancer cell invasiveness through fascin expression and that ectopic expression of Rab25 aggravates metastasis of ovarian cancer cells to the lung. We thus demonstrate a novel role of a β1 integrin/EGFR/VEGF-A/Snail signaling cascade in Rab25-induced cancer cell aggressiveness through induction of fascin expression, thus providing novel biomarkers and potential therapeutic targets for Rab25-expressing cancer cells.
Biomarkers
;
Cell Lineage
;
Ectopic Gene Expression
;
GTP-Binding Proteins
;
Lung
;
Neoplasm Metastasis
;
Ovarian Neoplasms
;
Snails
;
Up-Regulation
;
Vascular Endothelial Growth Factor A
9.Performance Comparison of ImmunoCAP and HYTEC 288 in the Quantitative Tests of Allergen-specific IgE.
Seung Hee LEE ; Sun Min LEE ; Hyung Hoi KIM ; Chulhun L. CHANG ; Eun Yup LEE
Laboratory Medicine Online 2014;4(1):43-50
BACKGROUND: In vitro measurement of allergen-specific IgE has become an important part of allergy diagnoses. HYTEC 288 system (Hycor Biomedical Inc., USA), which was recently introduced in Korea, is a fully automated immunoassay for quantitative measurements of allergen-specific IgE. In this study, we compared the clinical utility of this in vitro allergy test with that of ImmunoCAP assay (ImmunoDiagnostics, Sweden). METHODS: To evaluate the reproducibility of HYTEC 288 system, 50 serum samples were tested in duplicate each for Dermatophagoides pteronyssinus (d1) and D. farinae (d2) specific IgE. To assess the agreement between ImmunoCAP and HYTEC 288 assays, 56 serum samples were tested for the other 21 allergen-specific IgE. RESULTS: No significant differences within the range of quantitative analysis were observed between HYTEC 288 and ImmunoCAP assays for d1 and d2 (P=0.65 and 0.55, respectively). The agreements of HYTEC allergen-specific IgE assay with ImmunoCAP within +/-1 class grade were 80% and 100% for d1 and d2, respectively. The correlation coefficients between HYTEC 288 and ImmunoCAP results within the range of quantitative analysis were overally 0.90, regardless of allergen, for d1 and d2 specific IgE, 0.91 and 0.98, respectively. Running times for the HYTEC 288 and Phardia 100 were 5.5 and 4.6 min per test, respectively. CONCLUSIONS: Hycor HYTEC 288 showed a favorable agreement with ImmunoCAP and can be used for fully automated quantitative measurements of allergen-specific IgE in the clinical laboratory.
Automation
;
Dermatophagoides pteronyssinus
;
Diagnosis
;
Hypersensitivity
;
Immunoassay
;
Immunoglobulin E*
;
Korea
;
Running
10.The Regulators of VEGF Expression in Mouse Ovaries.
So Young SHIN ; Ho Jung LEE ; Duck Sung KO ; Hoi Chang LEE ; Won Il PARK
Yonsei Medical Journal 2005;46(5):679-686
The objectives of this study were to explore whether ovarian vascular endothelial growth factor (VEGF) expression in mice can be regulated by IL-6 (interleukin-6), angiotensin II, FSH, and hCG; and to test whether the mouse ovarian VEGF expression can result in angiogenesis. The ICR mice were sacrificed, and their ovaries were recovered. Recovered ovaries were treated with IL-6, angiotensin II, FSH, and hCG separately and incubated for 24 hours in alpha-MEM. Expression of mRNA and protein of VEGF were assessed by RT-PCR and immunohistochemistry. The resulting angiogenesis was evaluated through immunohistochemical analysis for CD34. Treatment of mice ovaries with IL-6, FSH, and hCG resulted in a significant increase of VEGF mRNA, and IL-6 was the most potent inducer of VEGF. IL-6 and FSH resulted in increased neovascularization in the follicular phase of mouse ovaries. In contrast, angiotensin II could not increase VEGF expression or neovascularization. We documented an in vitro increase in VEGF expression by IL-6, FSH, and hCG; and reaffirmed that the proliferative response of murine ovarian endothelial cells paralleled an increase of VEGF expression.
Vascular Endothelial Growth Factor A/analysis/*genetics
;
RNA, Messenger/analysis
;
Ovary/*metabolism
;
Mice, Inbred ICR
;
Mice
;
Interleukin-6/pharmacology
;
Immunohistochemistry
;
Gene Expression Regulation/*drug effects
;
Follicle Stimulating Hormone/pharmacology
;
Female
;
Chorionic Gonadotropin/pharmacology
;
Antigens, CD34/analysis
;
Animals