Study on 60 patients with chronic hepatitis at Infectious diseases department, hospital 103 from February to July 2003. Patients were divided into 2 groups: group 1 included 30 patients who were treated by Atcanninh pack 20g, 3 packs/day; group 2 included 30 patients who were treated by glucose, bile tonic drug, Vitamin B, C. Results: Atcanninh could reduce rapidly some clinical symptoms as fatigue, lose appetite, jaundice, yellow urine. It reduced quickly the blood level of SGOT, SGPT and Bilirubin after 2 to 3 weeks of treatment. Comparing to control group, Atcanninh reduced significantly HBsAg, HBV-DNA concentrations and rate of seroconversion also higher (14.3% compares to 0% with p<0.05) after 3 months
Hepatitis B, Chronic ; Therapeutics

The improvement of synthesis of 10-(trifluoroethoxy)-dihydroartemisinin was described. The improved procedure has some advantages like mild reaction conditions, good yields of products, operational simplicity and the ease of isolation and purification of the products
analogs & derivatives ; chemistry ; pharmacy ; Artemisinins

Introduction: The two currently licensed human papillomavirus (HPV) vaccines are highly efficacious in preventing cervical pre-cancers related to HPV 6, 11, 16 and 18. Before implementing a large-scale HPV vaccine campaign in Viet Nam, information about the prevalence of infection with the HPV vaccine types is required. This study was done in Can Tho, the province with the highest prevalence of cervical cancer in the south of Viet Nam, to explore the distribution of other high-risk types of HPV among married women in this province. Method: The study employed a cross-sectional design with multistage sampling. A total of 1000 participants were randomly selected, interviewed and given gynaecological examinations. HPV infection status and HPV genotyping test were completed for all participants. Results: A broad spectrum of HPV types was reported in this study. The prevalence of cases infected with HPV 16 and/or 18 was 7%; the prevalence of cases infected with other high-risk HPV types was 6%. The highest prevalence for single and multiple infections, as well as for high-risk infections, was reported for the youngest age group (less than 30 years). Discussion: While it is relevant to implement an HPV vaccine campaign in Viet Nam due to the high prevalence of infection with HPV 16 and/or 18, it is important to note that one can be infected with multiple types of HPV. Vaccination does not protect against all types of high-risk HPV. Future vaccine campaigns should openly disclose this information to women receiving vaccines.

We studied on 85 patients with Acute B Hepatitis (ABH) on process of markers of Hepatitis B virus (HBV) after recovering 2 years. The results showed that the rate of chronic HBsAg carriers: not fever before jaundice; long lasting mild pain in liver; nausea and vomit before jaundice. High level of SGOT and SGPT is under 10 times and high level of Bilirubin is under 5 times compared with normal index; high level of T lymphocytes cells is mild; HBeAg positive when entering hospital and long lasting positive
Hepatitis B ; Epidemiologic Methods

Background: Paraneoplastic syndrome is a rare syndrome on lung cancer patients in Vietnam and in the world. Objective: To define the percentage of the common paraneoplastic syndromes on lung cancer patients and research the clinical and investigations of these syndromes. Subjects and method: A study included 570 patients diagnosed lung cancer based on histopathological and cytological evidences, treated in Department of Respiratory in Bach Mai Hospital from 2003 to 2005. This was a descriptive, retrospective study. Results and conclusions: 19.47% of the patients had common paraneoplastic syndromes. Pierre Marie's syndrome was the most common (65.8%), followed by Schwartz-Bartter's syndrome (25.2%). 64.8% of the patients were 50 to 69 years old, 88.3% were men, 83.8% were smokers. 66.6% of patients were the severe periods. 30.7% of patients were diagnosed histologically adenocarcinoma. 12.8% of patients had Pierre Marie's syndrome, 5.3% had Schwartz-Bartter's syndrome, 1.9% had hypercalcemia of malignancy and 1.9% had thromboembolism.
Lung Neoplasms/ pathology ; Paraneoplastic Syndromes/ pathology

Background: HbA1c quantification is the first important work in long- term controlling of diabetes, which helps to assess the status of diabetes from 2 to 3 months before testing. HbA1c is essential testing to follow up compliance with treatment or not of patients.\r\n', u'Objectives: To study the role of blood HbA1c and micoalbuminuria in the treatment of diabetes.\r\n', u'Subjects and methods: The study was conducted on 124 patients (71 male and 53 female) suffering from diabetes mellitus. Among them, 124 patients were tested for blood HbA1c, 52 patients were tested for both blood HbA1c and micoalbuminuria. The study used the automatic immunological and biochemical techniques. \r\n', u'Results: Concentration of HbA1c was 8.10\xb12.65%, glycemia 9.83\xb14.82mmol/l, urinary micro albumin 76.5\xb196.90mg/l.\r\n', u'There was close relationship between glycaemia and HbA1c; but the relation between micoalbuminuria with HbA1c and glycaemia was not found. The control of diabetes mellitus was poor if glycaemia over 10.0mmol/l and/or HbA1c over 10%. \r\n', u'Conclusion: The techniques applied in the study were precise, rapid and convenient for the patients.\r\n', u'
HbA1c ; microalbuminuria ; diabetes

Background: Dengue fever remains a major public health problem in Vietnam. It was transmitted through two main Aedes species, namely Aedes aegypti and Aedes albopictus in which Aedes aegypti played the predominant role in transmitting the dengue viruses (accounted for 94% of the Aedes genus).Different groups of insecticides have been widely used in the community. As a consequence, it increased the resistance level of Aedes vectors to the insecticides. Therefore, a new synthesized insecticide was required for future control and prevention of dengue epidemics. \r\n', u'Objectives: To evaluate the efficacy of Cynoff 25 ULV in suppressing Aedes species in Vietnam. \r\n', u'Subjects and methods: The study was conducted in the entomology laboratory and in the fields of Ha Tay province. ULV spraying was implemented in Hiengiang commune, Thuongtin district, in comparison with a control area, Van Mo commune in Ha Dong town.\r\n', u'Results and conclusions: : Cynoff 25 ULV had a high efficacy that kills over 90% of 2 dengue vector species, namely Aedes aegypti and Aedes albopicctus after 24 hours exposure at the distance of 30 meters from the brass nozzle of a STIHL SR 400 sprayer. In the field trials, Cynoff 25 ULV also had high efficacy in killing Aedes species, e.g. 100% of Aedes species were killed after spraying and the effects lasted for 3 months for Aedes aegypti and one month for Aedes albopictus species. The insecticide had no side-effects or any other adverse effects to humans, livestock and the environment in the intervention areas. \r\n', u'
cynoff 25 ULV ; aedes species ; dengue vectors

A prospective case–control study was conducted in urban districts in Hanoi, northern Vietnam to evaluate the effect of migration on the risk of hospitalisation for dengue in a Vietnamese urban population. We enrolled laboratory-confirmed dengue patients aged >18 years who were hospitalised in local hospitals in November and December 2010. Four neighbourhood-matched controls for each case were recruited within a week of hospitalisation. Sociodemographic data were collected by interviews, and the number of immature and adult mosquitoes within household premises was counted by entomological survey. Matched-pair analyses were conducted using conditional logistic regression models. Among 43 cases and 168 controls, 84% and 83% were migrants from rural areas, respectively. Although statistical significance was marginal, recent migration (residing in study area for <5 years) independently increased the risk of hospitalisation for dengue compared with inhabitants after controlling for potential confounders (adjusted odds ratio [aOR] = 3.78; 95% confidence interval [CI] = 0.99–14.27), whereas longer-term migration (residing in study area for >6 years) did not change the risk (aOR = 1.1; 95% CI = 0.30–4.05). Younger age (18–34 years) (aOR = 7.26; 95% CI = 2.39–22.06) and higher adult Aedes aegypti infestation level within household premises (aOR = 9.25; 95% CI = 1.68–51.09) were also independently associated with hospitalisation for dengue. Recent migration from rural areas seems to increase the risk of hospitalisation for dengue in urban populations in endemic areas. Further research including cohort study should be done to confirm the impact of migration on the risk of dengue in urban areas.

A 38-year-old female patient, with healthy history, was vaccinated with ChAdOx1 nCoV-19 (Astra Zeneca Cambridge, UK). Five days after the second injection, the patient presented headache, vertigo, then fatigue, nervousness, palpitations, shortness of breath, small amplitude tremors, and sweating episodes. Laboratory investigation revealed a suppressed thyroid-stimulating hormone (TSH), with elevated free thyroxine. However, the TSH receptor antibody and anti-thyroid peroxidase antibody were normal and thyroid-stimulating immunoglobulin negative. The patient was maintained on Metoprolol, and no specific treatment was added. After 3 months of following, the patient now feels comfortable. Our literature review found that 21 cases of subacute thyroiditis (SAT) following coronavirus disease 2019 (COVID-19) vaccines were reported. Most patients were young women who presented neck pain and systemic symptoms, with or without fever. These symptoms can appear as early (3 to 5 days), or later (1 month) after vaccination, regardless of vaccine type and mechanism of action. Laboratory tests showed decreased levels of TSH and elevated thyroid hormone. The mechanism of this event remains unknown. Further study is recommended to investigate the possible predisposing factors to developing SAT after receiving the COVID-19 vaccine.

Introduction: Antiviral resistance has been reported in seasonal influenza A viruses and avian influenza A(H5N1) viruses in Viet Nam, raising concerns about the efficacy of treatment. Methods: We analysed specimens from two sources during the period 2009–2012: influenza-positive samples from influenza-like illness patients at sentinel clinics in northern Viet Nam and isolates from patients with confirmed A(H5N1) infections. Pyrosequencing was used to detect mutations: H275Y [for A(H1N1) and A(H5N1)], E119V [for A(H3N2)] and I117V [for A(H5N1)]. A neuraminidase inhibition assay was used to determine the Inhibitory Concentration 50 (IC50) values for all influenza A and B isolates. Results: There were 341 influenza A positive samples identified; influenza A(H1N1)pdm09 was identified most frequently (n = 215). In 2009, oseltamivir resistance was observed in 100% (19 of 19) of seasonal A(H1N1) isolates and 1.4% (3/215) of A(H1N1)pdm09 isolates. This H275Y mutation was not found in influenza subtypes A(H5N1) or A(H3N2) isolates. Discussion: In Viet Nam, seasonal and A(H5N1) influenza vaccines are not currently available; thus, effective treatment is required. The presence of oseltamivir-resistant viruses is therefore a concern. Active surveillance for oseltamivir resistance among influenza viruses circulating in Viet Nam should be continued.