1.Acceptability of medical abortion in women living in Ho Chi Minh city
Journal of Practical Medicine 2005;503(2):35-37
594 women underwent medical abortion in Tu Du Hospital of Ho Chi Minh city were interviewed from March to December 2004. Mean age of these women was 24.3. Among them, medical abortion to terminate pregnancy is 52.2%, abortion 47.8%, miscarriage 12.1%. Reasons for choosing medical abortion included: this is a new method (52%), reducing dangerous complications (73%), fear of pain due to surgical abortion (94%), available (96.3%), confidence (97.5%). 68% of them like to use medication at home, 38% did it in health facilities. Multivariable analysis showed that there were correlation between use medication at home or in health facilities with age and the success or unsuccess of recent medical abortion
Abortion, Induced
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Women
2.Drug resistance and the genotypic characteristics of rpoB and katG in rifampicin- and/or isoniazid-resistant Mycobacterium tuberculosis isolates in central Vietnam
Thi Binh Nguyen NGUYEN ; Thi Kieu Diem NGUYEN ; Van Hue TRƯƠNG ; Thi Tuyet Ngoc TRAN ; Van Bao Thang PHAN ; Thi Tuyen NGUYEN ; Hoang Bach NGUYEN ; Viet Quynh Tram NGO ; Van Tuan MAI ; Paola MOLICOTTI
Osong Public Health and Research Perspectives 2023;14(5):347-355
Objectives:
Tuberculosis (TB) and drug-resistant TB (DR-TB) are national health burdens in Vietnam. In this study, we investigated the prevalence of rifampicin (RIF) and/or isoniazid (isonicotinic acid hydrazide, INH) resistance in patients with suspected TB, and applied appropriate techniques to help rapidly target DR-TB.
Methods:
In total, 1,547 clinical specimens were collected and cultured using the BACTEC MGIT system (Becton Dickinson and Co.). A resazurin microtiter assay (REMA) was used to determine the proportions of RIF and/or INH resistance. A real-time polymerase chain reaction panel with TaqMan probes was employed to identify the mutations of rpoB and katG associated with DR-TB in clinical isolates. Genotyping of the identified mutations was also performed.
Results:
A total of 468 Mycobacterium tuberculosis isolates were identified using the REMA. Of these isolates, 106 (22.6%) were found to be resistant to 1 or both antibiotics. Of the resistant isolates, 74 isolates (69.8%) were resistant to isoniazid (INH) only, while 1 isolate (0.94%) was resistant to RIF only. Notably, 31 isolates (29.24%) were resistant to both antibiotics. Of the 41 phenotypically INH-resistant isolates, 19 (46.3%) had the Ser315Thr mutation. There were 8 different rpoB mutations in 22 (68.8%) of the RIF-resistant isolates. The most frequently detected mutations were at codons 531 (37.5%), 526 (18.8%), and 516 (6.3%).
Conclusion
To help prevent new cases of DR-TB in Vietnam, it is crucial to gain a comprehensive understanding of the genotypic DR-TB isolates.